Category: 1504965-88-1

Electric Literature of 1504965-88-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1504965-88-1 as follows.

The compound (1.83g, 10 mmol) obtained from Preparation Example 83-1 was dissolved in chloroform (50ml), and the solution was cooled to 0. Acetic anhydride (2.36ml, 25mmol) was added thereto, and the solution was stirred for 1 hour at room temperature. Potassium acetate (0.29g, 3mmol) and isopentylnitrite (2.69ml, 20mmol) were added thereto, and the mixture was heated to 70 and stirred for 16 hours. The mixture was cooled to room temperature, diluted with dichloromethane, washed with saturated solution of sodium hydrogen carbonate, dried over anhydrous magnesium sulfate and filtered. Filtrate was distilled under reduced pressure and separated by column chromatography to obtain the title compound (0.77g, 33%).[1134] NMR:1H-NMR(500HMz, CDCl3); delta 9.00 (d, 1H), 8.14 (s, 1H), 7.46 (d, 1H), 3.98(s, 3H), 2.80 (s, 3H)

According to the analysis of related databases, 1504965-88-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LG LIFE SCIENCES LTD.; LEE, Sung Bae; PAEK, Seung Yup; YOON, Sook Kyung; YOON, Seung Hyun; CHOI, Jeung Soon; WO2014/73904; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 1504965-88-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1504965-88-1, name is Methyl 5-amino-2-fluoro-4-methylbenzoate, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of methyl 5-amino-2-fluoro-4-methyl-benzoate (500 mg, 2.73 mmol) in methanol (3 mL) was added ammonia (2 mL of 7 M, 14 mmol), and the mixture was stirred for 16 hours at room temperature. Additional ammonia (2 mL of 7 M, 14 mmol) was added and the reaction was stirred for 6 hours. The reaction mixture was concentrated in vacuo to afford 5-amino-2-fluoro-4-methyl- benzamide (390 mg, 85%) as a yellow solid. ESI-MS m/z calc. 168.07, found 169.0 (M+l)+; retention time (Method F): 0.42 minutes (1.5 minute run).

The chemical industry reduces the impact on the environment during synthesis Methyl 5-amino-2-fluoro-4-methylbenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; AHMAD, Nadia; ANDERSON, Corey; ARUMUGAM, Vijayalaksmi; ASGIAN, Iuliana, Luci; CAMP, Joanne, Louise; FANNING, Lev Tyler, Dewey; HADIDA RUAH, Sara, Sabina; HURLEY, Dennis; SCHMIDT, Yvonne; SHAW, David; SHETH, Urvi, Jagdishbhai; THOMSON, Stephen, Andrew; (691 pag.)WO2019/14352; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics