Synthetic Route of 150319-83-8, A common heterocyclic compound, 150319-83-8, name is Methyl 2-(3-aminophenyl)acetate hydrochloride, molecular formula is C9H12ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1) (3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetic acid (1.0 g) obtained in Example 1-(1) was converted into acid chloride according to the method of Example 53, which was reacted with 3-aminophenylacetic acid methyl ester hydrochloride (0.43 g) to obtain 3-[[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]aminophenylacetic acid methyl ester (0.85 g) as a colorless amorphous powder. 1H-NMR (CDCl3) delta: 0.959 (3H, s), 1.024 (3H, s), 2.025 (3H, s), 2.812 (1H, dd, J=5.6, 14.1 Hz), 3.002 (1H, dd, J=7.2, 14.1 Hz), 3.538 (1H, d, J=14.2 Hz), 3.608 (2H, s), 3.620 (3H, s), 3.690 (3H, s), 3.732 (1H, d, J=11.2 Hz), 3.870 (1H, d, J=11.2 Hz), 3.894 (3H, s), 4.403 (1H, dd, J=5.8, 7.2 Hz), 4.564 (1H, d, J=14.2 Hz), 6.299 (1H, s), 6.645 (1H, d, J=2.0 Hz), 6.95-7.48 (9H, m), 7.847 (1H, br).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Kori, Masakuni; Miki, Takashi; Nishimoto, Tomoyuki; Tozawa, Ryuichi; US2003/78251; (2003); A1;,
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