148438-00-0, name is Methyl 3-(trifluoromethoxy)benzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: esters-buliding-blocks
Reference Example 6 2.5 M Butyl lithium in hexane (18.5ml) was added under an inert atmosphere to a solution of 3-fluorobenzoic acid (3.0g) in dry tetrahydrofuran at -75oC. The reaction mixture was stirred at -78oC overnight. A solution of methyl 3-trifluoromethoxybenzoate (4.6g) in dry tetrahydrofuran was added and after 2 hours the reaction mixture was allowed to warm to -20oC. 2N hydrochloric acid was added, the mixture and the organic layer was separated and dried (MgSO4). Evaporated the solvent and triturated the residue with hexane to yield 3-fluoro-2-(3-trifluoromethoxybenzoyl)benzoic acid (4.3g) as a white solid, m.p. 135-140oC.
The synthetic route of 148438-00-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RHONE POULENC AGRICULTURE LTD.; EP634404; (1995); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics