Category: 14814-06-3

Lazar, Carmen published the artcileDrug Evolution Concept in Drug Design: 1. Hybridization Method, Synthetic Route of 14814-06-3, the main research area is drug design; chem evolution drug hybridization.

A novel concept, “”drug evolution””, is proposed to develop chem. libraries that have a high probability of finding drugs or drug candidates. It converts biol. evolution into chem. evolution. In this paper, the authors present “”hybridization”” drug evolution, which is the equivalent of sexual recombination of parental genomes in biol. evolution. The hybridization essentially shuffles the building blocks of the parent drugs and ought to drug(s); no drug evolution can otherwise occur. The authors hybridized two drugs, benzocaine and metoclopramide and generated 16 mols. that include the parent drugs, four known drugs, and two mols. whose therapeutic activities are reported. The unusually high number of drugs and drug candidates in the library encourages high expectations of finding new drug(s) or drug candidate(s) within the remaining eight compounds Interestingly, the therapeutic applications of the eight drugs or drug candidates in the library are fairly diverse as 38 therapeutic applications and 25 mol. targets are counted. Therefore, the library fits as a general chem. library for unspecified therapeutic activities. The hybridization of other two drugs, aspirin and cresotamide, is also described to demonstrate the generality of the method.

Journal of Medicinal Chemistry published new progress about Drug design. 14814-06-3 belongs to class esters-buliding-blocks, name is Ethyl 4-amino-2-methoxybenzoate, and the molecular formula is C10H13NO3, Synthetic Route of 14814-06-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lazar, Carmen published the artcileDrug Evolution Concept in Drug Design: 1. Hybridization Method, Synthetic Route of 14814-06-3, the main research area is drug design; chem evolution drug hybridization.

A novel concept, “”drug evolution””, is proposed to develop chem. libraries that have a high probability of finding drugs or drug candidates. It converts biol. evolution into chem. evolution. In this paper, the authors present “”hybridization”” drug evolution, which is the equivalent of sexual recombination of parental genomes in biol. evolution. The hybridization essentially shuffles the building blocks of the parent drugs and ought to drug(s); no drug evolution can otherwise occur. The authors hybridized two drugs, benzocaine and metoclopramide and generated 16 mols. that include the parent drugs, four known drugs, and two mols. whose therapeutic activities are reported. The unusually high number of drugs and drug candidates in the library encourages high expectations of finding new drug(s) or drug candidate(s) within the remaining eight compounds Interestingly, the therapeutic applications of the eight drugs or drug candidates in the library are fairly diverse as 38 therapeutic applications and 25 mol. targets are counted. Therefore, the library fits as a general chem. library for unspecified therapeutic activities. The hybridization of other two drugs, aspirin and cresotamide, is also described to demonstrate the generality of the method.

Journal of Medicinal Chemistry published new progress about Drug design. 14814-06-3 belongs to class esters-buliding-blocks, name is Ethyl 4-amino-2-methoxybenzoate, and the molecular formula is C10H13NO3, Synthetic Route of 14814-06-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics