Category: 14667-47-1

Synthesis of biologically active 2-hydroxy-5-pyridinoyl amino acids and 2-(aminoacyl)aminopyridine-3-(or -5-)carboxylic acid derivatives was written by El-Naggar, A. M.;El-Haddad, A. F.;Badie, M. F.;Latif, M. S.;Gommaa, A. M.. And the article was included in Afinidad in 1983.Related Products of 14667-47-1 This article mentions the following:

6-Hydroxy-3-pyridinecarboxylate condensed with H-X-OMe.HCl (X = Gly, Ala, Ser, Val, Leu) in DMF containing DCC and Et₃N to give 55-69% pyridinecarbonyl amino acids I (R = OMe), which were treated with N₂H₄ to give 77-91% I (R = NHNH₂). I (X = Val, Leu; R = NHNH₂) were coupled with H-Ser-OMe.HCl by the azide method to give the corresponding dipeptides in 43-51% yield. Pyridinyl amino acid derivatives II and III [R¹ = tosyl (Tos), phthaloyl (Pht); X¹ = Ala, Ser, Val, Leu; R² = OMe] were prepared in 54-80% yields by condensing tosyl or phthaloyl amino acids with Me 2-amino-3-pyridinecarboxylate and Me 6-amino-3-pyridinecarboxylate, resp. II and III (R¹ = Tos; X¹ = Ser, Val, Leu; R² = OMe) were treated with N₂H₄ to give 55-80% II and III (R¹ = Tos, R² = NHNH₂), whereas II and III (R² = Pht; X¹ = Ala, Ser, Val, Leu; R² = OMe) underwent hydrazinolysis to give 52-66% II and III (R¹ = H, R² = NHNH₂). Dipeptides IV (X²-X³ = Val-Ser, Ala-Val, Ser-Leu) and V (X²-X³ = Ala-Ser, Ser-Val, Val-Leu) were also prepared Several of these compounds exhibited antimicrobial activity. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Related Products of 14667-47-1).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 14667-47-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold was written by Manera, Clementina;Saccomanni, Giuseppe;Malfitano, Anna Maria;Bertini, Simone;Castelli, Francesca;Laezza, Chiara;Ligresti, Alessia;Lucchesi, Valentina;Tuccinardi, Tiziano;Rizzolio, Flavio;Bifulco, Maurizio;Di Marzo, Vincenzo;Giordano, Antonio;Macchia, Marco;Martinelli, Adriano. And the article was included in European Journal of Medicinal Chemistry in 2012.SDS of cas: 14667-47-1 This article mentions the following:

CB2 receptor ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathol. processes. Using the previously described series of 1,8-naphthyridin-2(1H)-on-3-carboxamides as a lead class, several nitrogen heterocyclic derivatives, characterized by different central cores, were synthesized and tested for their affinity toward the human CB1 and CB2 cannabinoid receptors. The obtained results suggest that the new series of quinolin-2(1H)-on-3-carboxamides, 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamides and 1,2-dihydro-2-oxopyridine-3-carboxamides represent novel scaffolds very suitable for the development of promising CB2 ligands. Furthermore, the newly synthesized CB2 ligands inhibit proliferation of several cancer cell lines. In particular, it was demonstrated that in DU-145 cell line these ligands exert a CB2-mediated anti-proliferative action and decrease the CB2 receptor expression levels. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1SDS of cas: 14667-47-1).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 14667-47-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics