Stanovnik, B. et al. published their research in Croatica Chemica Acta in 1972 | CAS: 14667-47-1

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of Methyl 2-aminonicotinate

Synthesis of isomeric 3-aminopyridopyrimidin-4(3H)ones was written by Stanovnik, B.;Tisler M.. And the article was included in Croatica Chemica Acta in 1972.Quality Control of Methyl 2-aminonicotinate This article mentions the following:

Structural assignments of the title compounds (I, II) obtained from H2NNH2 and III or IV resp. were achieved by chem. evidence and interpretation of ir, NMR and mass spectra. III and IV (R1 = CO2Et, CN) were prepared from esters of 2-aninopyridine-3-carboxylic (V) or 3-aminopyridine-2-carboxylic acids (VI) by heating with diethyl ethoxymethylene malonate or ethyl ethoxymethylenecyanacetate (VII). The ratio of cis:trans isomers in III (R1 = CN) prepared from V and VII was (NMR) 閳?:2. Treatment of III or IV with excess H2NNH2H2O in EtOH at room temperature gave I (R = NH2), or II (R = NH2) resp. I and II (R = NH2) were also obtainable from the condensation products of V or VI with Me2NCH(OMe)2 followed by a similar treatment with H2NNH2H2O. 2-Aminonicotinic acid hydrazide and diethoxymethyl acetate cyclized into I (R = N:CHOEt) which upon hydrolysis gave I (R = NH2). Treatment of I or II (R = NH2) with amyl nitrite gave I (R = H), which was treated with AC2O-pyridine to give I or II (R = NHAc) especially Condensation of V with cis- trans-2,5-diethoxy-tetrahydrofuran in AcOH under reflux gave 3-carbomethoxy-2-(N-pyrrolo)pyridine, which with polyphosphoric acid underwent pyrrole elimination to give methyl 2-aminopyridine-3-carboxylate. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Quality Control of Methyl 2-aminonicotinate).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of Methyl 2-aminonicotinate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brouwer, Chad et al. published their research in European Journal of Medicinal Chemistry in 2016 | CAS: 14667-47-1

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of Methyl 2-aminonicotinate

Translocator protein ligands based on N-methyl-(quinolin-4-yl)oxypropanamides with properties suitable for PET radioligand development was written by Brouwer, Chad;Jenko, Kimberly J.;Zoghbi, Sami S.;Morse, Cheryl L.;Innis, Robert B.;Pike, Victor W.. And the article was included in European Journal of Medicinal Chemistry in 2016.Application In Synthesis of Methyl 2-aminonicotinate This article mentions the following:

Modifications to an N-methyl-(quinolin-4-yl)oxypropanamide scaffold were explored to discover leads for developing new radioligands for PET imaging of brain TSPO (translocator protein), a biomarker of neuroinflammation. Whereas contraction of the quinolinyl portion of the scaffold or cyclization of the tertiary amido group abolished high TSPO affinity, insertion of an extra nitrogen atom into the 2-arylquinolinyl portion was effective in retaining sub-nanomolar affinity for rat TSPO, while also decreasing lipophilicity to within the moderate range deemed preferable for a PET radioligand. Replacement of a Ph group on the amido nitrogen with an iso-Pr group was similarly effective. Among others, compound 20 (N-methyl-N-phenyl-2-[2-(pyridin-2-yl)-1,8-naphthyridin-4-yloxy]propanamide) appears especially appealing for PET radioligand development, based on high selectivity and high affinity (Ki = 0.5 nM) for rat TSPO, moderate lipophilicity (logD = 2.48), and demonstrated amenability to labeling with carbon-11. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Application In Synthesis of Methyl 2-aminonicotinate).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of Methyl 2-aminonicotinate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hirai, Eizo et al. published their research in Chemical & Pharmaceutical Bulletin in 1966 | CAS: 14667-47-1

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C7H8N2O2

Behavior of 4-amino-5-carboxy-2-methylpyrimidine in aqueous solution was written by Hirai, Eizo. And the article was included in Chemical & Pharmaceutical Bulletin in 1966.Computed Properties of C7H8N2O2 This article mentions the following:

MeI (4 ml.) added to 1 g. 4-amino-5-ethoxycarbonyl-2-methylpyrimidine in 10 ml. Me2CO, the mixture refluxed 1 hr., and the precipitate formed on cooling heated 1 hr. on a steam bath with 10 ml. 5% HI gave 0.6 g. hemihydrate of the 1-methyl betaine of 4-amino-5-carboxy-2-methylpyrimidine, decomposed 226-7鎺?(aqueous alc.). The 1-methyl betaine of 2-aminonicotinic acid, decomposed 269-71鎺? and the 1-methyl betaine of 2-aminoisonicotinic acid were similarly prepared The basic ionization constants of 2-aminonicotinic acid (I) and 2-aminoisonicotinic acid (II) and of their Me and Et esters and 1-methyl betaines, and of 4-amino-5-carboxy-2-methylpyrimidine (III) and its Et ester and 1-methyl betaine were determined potentiometrically and spectrophotometrically. The basic pKa values of I and II were much lower than those calculated from the Hammett eq. I and II exist largely as zwitterions in H2O. On the basis of the uv absorption spectra of I-III as compared with those of the corresponding Et esters and 1-methyl betaines, I-III exist predominantly as zwitterions in H2O. An evaluation of the equilibrium constants between the zwitterion form and uncharged form in H2O for I and III from the Edsall and Blanchard equation (CA 27, 5233) is in agreement with this conclusion. Ir spectra of I-III in the solid state show that the compounds form an uncharged polymer linked by H bonding between the carboxyl and a nuclear N. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Computed Properties of C7H8N2O2).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C7H8N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Burchak, Olga N. et al. published their research in Journal of the American Chemical Society in 2011 | CAS: 14667-47-1

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of Methyl 2-aminonicotinate

Combinatorial Discovery of Fluorescent Pharmacophores by Multicomponent Reactions in Droplet Arrays was written by Burchak, Olga N.;Mugherli, Laurent;Ostuni, Mariano;Lacapere, Jean Jacques;Balakirev, Maxim Y.. And the article was included in Journal of the American Chemical Society in 2011.Application In Synthesis of Methyl 2-aminonicotinate This article mentions the following:

Fluorescence imaging in clin. diagnostics and biomedical research relies to a great extent on the use of small organic fluorescent probes. Because of the difficulty of combining fluorescent and mol.-recognition properties, the development of such probes has been severely restricted to a number of well-known fluorescent scaffolds. Here we demonstrate that autofluorescing druglike mols. are a valuable source of bioimaging probes. Combinatorial synthesis and screening of chem. libraries in droplet microarrays allowed the identification of new types of fluorophores. Their concise and clean assembly by a multicomponent reaction presents a unique potential for the one-step synthesis of thousands of structurally diverse fluorescent mols. Because they are based upon a druglike scaffold, these fluorophores retain their mol. recognition potential and can be used to design specific imaging probes. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Application In Synthesis of Methyl 2-aminonicotinate).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of Methyl 2-aminonicotinate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Burchak, Olga N. et al. published their research in Journal of the American Chemical Society in 2011 | CAS: 14667-47-1

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of Methyl 2-aminonicotinate

Combinatorial Discovery of Fluorescent Pharmacophores by Multicomponent Reactions in Droplet Arrays was written by Burchak, Olga N.;Mugherli, Laurent;Ostuni, Mariano;Lacapere, Jean Jacques;Balakirev, Maxim Y.. And the article was included in Journal of the American Chemical Society in 2011.Application In Synthesis of Methyl 2-aminonicotinate This article mentions the following:

Fluorescence imaging in clin. diagnostics and biomedical research relies to a great extent on the use of small organic fluorescent probes. Because of the difficulty of combining fluorescent and mol.-recognition properties, the development of such probes has been severely restricted to a number of well-known fluorescent scaffolds. Here we demonstrate that autofluorescing druglike mols. are a valuable source of bioimaging probes. Combinatorial synthesis and screening of chem. libraries in droplet microarrays allowed the identification of new types of fluorophores. Their concise and clean assembly by a multicomponent reaction presents a unique potential for the one-step synthesis of thousands of structurally diverse fluorescent mols. Because they are based upon a druglike scaffold, these fluorophores retain their mol. recognition potential and can be used to design specific imaging probes. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Application In Synthesis of Methyl 2-aminonicotinate).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of Methyl 2-aminonicotinate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kamenecka, Theodore M. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2005 | CAS: 14667-47-1

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 14667-47-1

Dipyridyl amines: Potent metabotropic glutamate subtype 5 receptor antagonists was written by Kamenecka, Theodore M.;Bonnefous, Celine;Govek, Steven;Vernier, Jean-Michel;Hutchinson, John;Chung, Janice;Reyes-Manalo, Grace;Anderson, Jeffery J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Reference of 14667-47-1 This article mentions the following:

Modulation of the metabotropic glutamate subtype 5 (mGluR5) receptor may be useful in the treatment of a variety of central nervous system disorders. Here, the discovery, synthesis, and biol. evaluation of dipyridyl amines as small mol. mGluR5 antagonists, is reported. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Reference of 14667-47-1).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 14667-47-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Krasavin, Mikhail et al. published their research in Synthetic Communications in 2006 | CAS: 14667-47-1

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Electric Literature of C7H8N2O2

Preparation and chemical behavior of 2-(tert-butoxycarbonyl)amino-3-bromomethyl pyridine, a novel alkylating agent was written by Krasavin, Mikhail;Shkavrov, Sergey;Kravchenko, Dmitry. And the article was included in Synthetic Communications in 2006.Electric Literature of C7H8N2O2 This article mentions the following:

Synthesis of a novel heterocyclic alkylating agent was developed. Its instability toward elevated temperatures and/or polar media can be used to prepare 8-aza-1,4-dihydrobenzo[1,3-d]oxazin-2-one. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Electric Literature of C7H8N2O2).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Electric Literature of C7H8N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Potowski, Marco et al. published their research in Organic Letters in 2021 | CAS: 14667-47-1

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application In Synthesis of Methyl 2-aminonicotinate

Copper(I/II)-Promoted Diverse Imidazo[1,2-α]pyridine Synthesis on Solid-Phase Bound DNA Oligonucleotides for Encoded Library Design was written by Potowski, Marco;Luettig, Ricarda;Vakalopoulos, Alexandros;Brunschweiger, Andreas. And the article was included in Organic Letters in 2021.Application In Synthesis of Methyl 2-aminonicotinate This article mentions the following:

DNA-encoded libraries designed around heterocyclic scaffolds have proven highly productive in target-based screening. Here, we show the synthesis of imidazopyridines on a controlled pore glass-coupled DNA oligonucleotide for solid phase-initiated encoded library synthesis. The target compounds were synthesized by a variant of the A3 coupling reaction from aminopyridines, alkynes, and aldehydes promoted by copper(I/II) and furnished diverse substituted scaffolds with functionalities for library design. Although proceeding under forcing conditions, it produced minimal DNA damage. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Application In Synthesis of Methyl 2-aminonicotinate).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application In Synthesis of Methyl 2-aminonicotinate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gandolfo, Concetta et al. published their research in Gazzetta Chimica Italiana in 1971 | CAS: 14667-47-1

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: esters-buliding-blocks

Ultraviolet absorption spectra and dipole moments of substituted pyridines. IV. Aminopyridinecarboxylate esters was written by Gandolfo, Concetta;Buemi, Giuseppe;Favini, Giorgio. And the article was included in Gazzetta Chimica Italiana in 1971.Category: esters-buliding-blocks This article mentions the following:

Calculated electron transition energies and dipole moments are in good agreement with exptl. values for Me amino nicotinates, Me amino picolinates, and Me amino isonicotinates. The preferred conformation of the CO2Me group is Am for the nicotinates, Bo for the picolinates, and Ap or Bp for the isonicotinates. The Am conformation is favored in nicotinates when the NH2 group is ortho or meta with respect to CO2Me. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Category: esters-buliding-blocks).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ronson, Thomas O. et al. published their research in Angewandte Chemie, International Edition in 2019 | CAS: 14667-47-1

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: Methyl 2-aminonicotinate

Ruthenium-Catalyzed Reductive Arylation of N-(2-Pyridinyl)amides with Isopropanol and Arylboronate Esters was written by Ronson, Thomas O.;Renders, Evelien;Van Steijvoort, Ben F.;Wang, Xubin;Wybon, Clarence C. D.;Prokopcova, Hana;Meerpoel, Lieven;Maes, Bert U. W.. And the article was included in Angewandte Chemie, International Edition in 2019.Recommanded Product: Methyl 2-aminonicotinate This article mentions the following:

A new three-component reductive arylation of amides with stable reactants (iPrOH and arylboronate esters), making use of a 2-pyridinyl (Py) directing group, is described. The N-Py-amide substrates are readily prepared from carboxylic acids and PyNH2, and the resulting N-Py-1-arylalkanamine reaction products are easily transformed into the corresponding chlorides by substitution of the HN-Py group with HCl. The 1-aryl-1-chloroalkane products allow substitution and cross-coupling reactions. Therefore, a general protocol for the transformation of carboxylic acids into a variety of functionalities is obtained. The Py-NH2 byproduct can be recycled. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Recommanded Product: Methyl 2-aminonicotinate).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: Methyl 2-aminonicotinate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics