Category: 144291-47-4

Electric Literature of C15H12O3On March 31, 1998, Blettner, Carsten G.; Koenig, Wilfried A.; Stenzel, Wolfgang; Schotten, Theo published an article in Synlett. The article was 《Poly(ethylene glycol)-supported liquid-phase synthesis of biaryls》. The article mentions the following:

The liquid-phase synthesis of biaryls via Suzuki cross-coupling reaction on poly(ethylene glycol) supports (PEGs) is described. The reaction is exemplified by parallel coupling of polymer-bound aryl halides with boronic acids. Four different PEGs were employed as soluble polymer supports for parallel synthesis. The generated libraries include both sterically hindered aryl halides and boronic acids. The reactions were run in the homogeneous phase and the synthetic sequences performed in parallel fashion. Quant. conversion in the Suzuki couplings was verified by 1H NMR. The polymer-bound products were isolated in 52-98% yield by either simple precipitation of the soluble support or column filtration.Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Electric Literature of C15H12O3) was used in this study.

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Electric Literature of C15H12O3 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fairlamb, Ian J. S.; Kapdi, Anant R.; Lynam, Jason M.; Taylor, Richard J. K.; Whitwood, Adrian C. published an article in Tetrahedron. The title of the article was 《Bis(triphenylphosphine)palladium(II)succinimide as a precatalyst for Suzuki cross-coupling-subtle effects exerted by the succinimide ligandã€?Electric Literature of C15H12O3 The author mentioned the following in the article:

A new palladium(II) precatalyst for Suzuki cross-coupling of aryl halides and organoboronic acids has been identified, namely bis(triphenylphosphine)palladium(II)succinimide [trans-bis(2,5-pyrrolidinedionato-N1)bis(triphenylphosphine)palladium] (I). The precatalyst is easily prepared from palladium(0) precursors, such as (Ph3P)4Pd or Pd2dba3·CHCl3/Ph3P and succinimide, is air, light and moisture stable, and may be employed with a variety of substrates to give the cross-coupled products, in good yields and in reasonable time, at relatively low catalyst loadings. It was shown here that subtle differences exist between a pseudohalide (succinimide) ligand and a chloride ligand. It is often assumed that palladium(II) catalysts are converted into palladium(0) species, however it was suggested that the halide/pseudohalide has an effect on the catalytically active palladium intermediates. The presence of free phosphine was detected in reactions thus studied.Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Electric Literature of C15H12O3) was used in this study.

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Electric Literature of C15H12O3 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《A new precatalyst for the Suzuki reaction-a pyridyl-bridged dinuclear palladium complex as a source of mono-ligated palladium(0)》 was published in New Journal of Chemistry in 2004. These research results belong to Beeby, Andrew; Bettington, Sylvia; Fairlamb, Ian J. S.; Goeta, Andres E.; Kapdi, Anant R.; Niemelae, Elina H.; Thompson, Amber L.. Category: esters-buliding-blocks The article mentions the following:

A dinuclear pyridyl-bridged palladium complex, trans-(P,N)-[PdBr(μ-C5H4N-C2,N)(PPh3)]2 (I), was obtained from material isolated from the Suzuki cross-coupling reaction of 2-bromopyridine with 2,4-difluorophenylboronic acid in the presence of catalytic (PPh3)4Pd. I was an effective precatalyst for the Suzuki cross-coupling reactions of a variety organoboronic acids and aryl bromides, and represents a useful source of mono-ligated palladium(0), “”(Ph3P)Pd(0)””. In the experiment, the researchers used many compounds, for example, Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Category: esters-buliding-blocks)

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Category: esters-buliding-blocks They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《General and Practical Carboxyl-Group-Directed Remote C-H Oxygenation Reactions of Arenes》 was published in Chemistry – A European Journal in 2013. These research results belong to Wang, Yang; Gulevich, Anton V.; Gevorgyan, Vladimir. Category: esters-buliding-blocks The article mentions the following:

Two complimentary methods, the Cu-catalyzed reaction and the K2S2O8-mediated transformation, for carboxyl- group-directed remote C-H oxygenation reaction of arenes were developed.Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Category: esters-buliding-blocks) was used in this study.

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Category: esters-buliding-blocks They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2013,Applied Organometallic Chemistry included an article by Lei, Xiangyang; Obregon, Karla A.; Alla, Jhansi. Quality Control of Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate. The article was titled 《Suzuki-Miyaura coupling reactions of aryl chlorides catalyzed by a new nickel(II) σ-aryl complex》. The information in the text is summarized as follows:

A new nickel(II) σ-aryl complex, trans-chloro(9-phenanthrenyl)bis(triphenylphosphine)nickel(II), was used as a precatalyst for the Suzuki-Miyaura coupling reactions of aryl chlorides. The catalytic conditions were optimized by investigating the cross-coupling of p-chloroanisole with phenylboronic acid. The results show that this complex is efficient for both electron-rich and electron-deficient aryl chlorides, though it gives better yields for activated arylboronic acids than deactivated ones. All isolated cross-coupled biaryl products have been characterized by 1H and 13C NMR, and their spectral data are consistent with those reported. Side products from the coupling of arylboronic acid with the precatalyst complex have also been isolated and characterized, which is helpful for understanding the coupling mechanism. Copyright 2013 John Wiley & Sons, Ltd. In the experimental materials used by the author, we found Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Quality Control of Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate)

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters.Quality Control of Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: 144291-47-4On October 13, 2016 ,《Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead》 was published in ACS Medicinal Chemistry Letters. The article was written by Terakado, Masahiko; Suzuki, Hidehiro; Hashimura, Kazuya; Tanaka, Motoyuki; Ueda, Hideyuki; Kohno, Hiroshi; Fujimoto, Taku; Saga, Hiroshi; Nakade, Shinji; Habashita, Hiromu; Takaoka, Yoshikazu; Seko, Takuya. The article contains the following contents:

Lysophosphatidic acid (LPA) evokes various physiol. responses through a series of G protein-coupled receptors known as LPA1-6. A high throughput screen against LPA1 gave compound 4′-{[(4-methoxybenzoyl)(3-phenylpropyl)amino]methyl}-2-biphenylcarboxylic acid (7a) as a hit. The subsequent optimization of 7a led to ONO-7300243 (17a) as a novel, potent LPA1 antagonist, which showed good efficacy in vivo. The oral dosing of 17a at 30 mg/kg led to reduced intraurethral pressure in rats. Notably, this compound was equal in potency to the α1 adrenoceptor antagonist tamsulosin, which is used in clin. practice to treat dysuria with benign prostatic hyperplasia (BPH). In contrast to tamsulosin, compound 17a had no impact on the mean blood pressure at this dose. These results suggest that LPA1 antagonists could be used to treat BPH without affecting the blood pressure. Herein, the authors report the hit-to-lead optimization of a unique series of LPA1 antagonists and their in vivo efficacy. In the part of experimental materials, we found many familiar compounds, such as Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Recommanded Product: 144291-47-4)

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Recommanded Product: 144291-47-4 Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application In Synthesis of Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylateOn May 13, 2015 ,《Simple Amine-Directed Meta-Selective C-H Arylation via Pd/Norbornene Catalysis》 appeared in Journal of the American Chemical Society. The author of the article were Dong, Zhe; Wang, Jianchun; Dong, Guangbin. The article conveys some information:

Herein we report a highly meta-selective C-H arylation using simple tertiary amines as the directing group. This method takes advantage of Pd/norbornene catalysis, offering a distinct strategy to control the site selectivity. The reaction was promoted by com. available AsPh3 as the ligand and a unique “”acetate cocktail””. Aryl iodides with an ortho electron-withdrawing group were employed as the coupling partner. A wide range of functional groups, including some heteroarenes, are tolerated under the reaction conditions. In addition, the amine directing group can be easily installed and transformed to other common versatile functional groups. We expect this C-H functionalization mode to have broad implications for developing other meta-selective transformations beyond this work. In the experiment, the researchers used many compounds, for example, Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Application In Synthesis of Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate)

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters.Application In Synthesis of Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lamotte, Yann; Faucher, Nicolas; Sancon, Julien; Pineau, Olivier; Sautet, Stephane; Fouchet, Marie-Helene; Beneton, Veronique; Tousaint, Jean-Jacques; Saintillan, Yannick; Ancellin, Nicolas; Nicodeme, Edwige; Grillot, Didier; Martres, Paul published an article on February 15 ,2014. The article was titled 《Discovery of novel indazole derivatives as dual angiotensin II antagonists and partial PPARγ agonists》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Name: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate The information in the text is summarized as follows:

Identification of indazole derivatives acting as dual angiotensin II type 1 (AT1) receptor antagonists and partial peroxisome proliferator-activated receptor-γ (PPARγ) agonists is described. Starting from telmisartan, the authors previously described that indole derivatives were very potent partial PPARγ agonists with loss of AT1 receptor antagonist activity. Design, synthesis and evaluation of new central scaffolds led us to the discovery of pyrrazolopyridine then indazole derivatives provided novel series possessing the desired dual activity. Among the new compounds, I was identified as a potent AT1 receptor antagonist (IC50 = 0.006 μM) and partial PPARγ agonist (EC50 = 0.25 μM, 40% max) with good oral bioavailability in rat. The dual pharmacol. of compound I was demonstrated in two preclin. models of hypertension (SHR) and insulin resistance (Zucker fa/fa rat).Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Name: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate) was used in this study.

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Name: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylateOn October 22, 2020 ,《First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters》 was published in Journal of Medicinal Chemistry. The article was written by Hernandez-Olmos, Victor; Heering, Jan; Planz, Viktoria; Liu, Ting; Kaps, Alexander; Rajkumar, Rinusha; Gramzow, Matthias; Kaiser, Astrid; Schubert-Zsilavecz, Manfred; Parnham, Michael J.; Windbergs, Maike; Steinhilber, Dieter; Proschak, Ewgenij. The article contains the following contents:

The first potent leukotriene B4 (LTB4) receptor type 2 (BLT2) agonists, endogenous 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT), and synthetic CAY10583 (CAY) have been recently described to accelerate wound healing by enhanced keratinocyte migration and indirect stimulation of fibroblast activity in diabetic rats. CAY represents a very valuable starting point for the development of novel wound-healing promoters. In this work, the first structure-activity relationship study for CAY scaffold-based BLT2 agonists is presented. The newly prepared derivatives showed promising in vitro wound-healing activity. In the experimental materials used by the author, we found Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Recommanded Product: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate)

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Recommanded Product: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Westaway, Susan M.; Brown, Samantha L.; Conway, Elizabeth; Heightman, Tom D.; Johnson, Christopher N.; Lapsley, Kate; Macdonald, Gregor J.; MacPherson, David T.; Mitchell, Darren J.; Myatt, James W.; Seal, Jon T.; Stanway, Steven J.; Stemp, Geoffrey; Thompson, Mervyn; Celestini, Paolo; Colombo, Andrea; Consonni, Alessandra; Gagliardi, Stefania; Riccaboni, Mauro; Ronzoni, Silvano; Briggs, Michael A.; Matthews, Kim L.; Stevens, Alexander J.; Bolton, Victoria J.; Boyfield, Izzy; Jarvie, Emma M.; Stratton, Sharon C.; Sanger, Gareth J. published their research in Bioorganic & Medicinal Chemistry Letters on December 15 ,2008. The article was titled 《The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor》.Application of 144291-47-4 The article contains the following contents:

Optimization of urea (5), identified from high throughput screening and subsequent array chem., has resulted in the identification of pyridine carboxamide (33, I) which is a potent motilin receptor agonist possessing favorable physicochem. and ADME profiles. Compound (33) has demonstrated prokinetic-like activity both in vitro and in vivo in the rabbit and therefore represents a promising novel small mol. motilin receptor agonist for further evaluation as a gastroprokinetic agent. In the experimental materials used by the author, we found Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Application of 144291-47-4)

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Application of 144291-47-4 Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics