Laurent, Sophie’s team published research in Contrast Media & Molecular Imaging in 2014-08-31 | CAS: 142896-15-9

Contrast Media & Molecular Imaging published new progress about Albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 142896-15-9 belongs to class esters-buliding-blocks, name is Methyl 2,6-dimethylisonicotinate, and the molecular formula is C9H11NO2, Recommanded Product: Methyl 2,6-dimethylisonicotinate.

Laurent, Sophie published the artcileBifunctional Gd(III) and Tb(III) chelates based on a pyridine-bis(iminodiacetate) platform, suitable optical probes and contrast agents for magnetic resonance imaging, Recommanded Product: Methyl 2,6-dimethylisonicotinate, the main research area is gadolinium terbium chelate MRI contrast agent; Ln(III) chelates; apoptotic cells; luminescence spectroscopy; magnetic resonace imaging (MRI); molecular imaging; pyridine-bis(iminodiacetate) chelators.

To study the physicochem. properties of lanthanide complexes derived from a bifunctional chelating agent based on a PMN-tetraacetic acid moiety {PMN-tetraacetic acid (1): [2,6-pyridinediylbis(methylene nitrilo)-tetraacetic acid]}, 4-carboxylic acid substituted pyridine derivative (2) was synthesized. This ligand forms heptadentate (N3O4) Ln(III) complexes (Ln = Gd, Eu, Tb), with two water mols. completing the inner coordination sphere of the metal. The parameters that govern the relaxivity of the Gd(III) complex and the luminescence of Eu(III) and Tb(III) complexes were obtained by 17O and 1H NMR studies and time-resolved fluorescence experiments, resp. The gadolinium and terbium complexes show interesting properties either for MRI or FOR optical imaging; i.e., for the Gd complex, a high proton relaxivity (r1 = 6.4 s-1 mm-1 at 20 MHz) with short water residence time (τM = 38.5 ns); for the Tb complex, a luminescence lifetime of 1.22 ms at room temperature and a luminescence quantum yield of 10%. The kinetic stability of these complexes toward blood protein, cation or bioactive oxyanion was also examined The Gd(2)(H2O)2 complex does not interact with human serum albumin, but undergoes a transmetalation reaction with Zn(II) in a phosphate buffer solution (pH 7.4), rather similar to that of Gd-DTPA-BMA(H2O). On the other hand, as observed for Eu and Tb complexes, these chelates do not form ternary complexes with bidentate anions such as L-lactate, citrate or carbonate. Finally, a phosphatidylserine-specific hexapeptide (TLVSSL) was grafted on Gd or Tb chelates, and the Gd-peptide conjugate was used in vitro for targeting apoptotic cells. Copyright © 2014 John Wiley & Sons, Ltd.

Contrast Media & Molecular Imaging published new progress about Albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 142896-15-9 belongs to class esters-buliding-blocks, name is Methyl 2,6-dimethylisonicotinate, and the molecular formula is C9H11NO2, Recommanded Product: Methyl 2,6-dimethylisonicotinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ma, Cong’s team published research in Organic Letters in 2019-04-05 | CAS: 142896-15-9

Organic Letters published new progress about Aromatic carboxylic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 142896-15-9 belongs to class esters-buliding-blocks, name is Methyl 2,6-dimethylisonicotinate, and the molecular formula is C9H11NO2, Application of Methyl 2,6-dimethylisonicotinate.

Ma, Cong published the artcileNickel-Catalyzed Carboxylation of Aryl and Heteroaryl Fluorosulfates Using Carbon Dioxide, Application of Methyl 2,6-dimethylisonicotinate, the main research area is aromatic carboxylic acid ester preparation; aryl heteroaryl fluorosulfate carbon dioxide carboxylation nickel catalyst.

The development of efficient and practical methods to construct carboxylic acids using CO2 as a C1 synthon is of great importance. Nickel-catalyzed carboxylation of aryl fluorosulfates and heteroaryl fluorosulfates with CO2 is described, affording arene carboxylic acids with good to excellent yields under mild conditions. In addition, a one-pot phenol fluorosulfation/carboxylation is developed.

Organic Letters published new progress about Aromatic carboxylic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 142896-15-9 belongs to class esters-buliding-blocks, name is Methyl 2,6-dimethylisonicotinate, and the molecular formula is C9H11NO2, Application of Methyl 2,6-dimethylisonicotinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Craig, Donald’s team published research in Tetrahedron Letters in 2005-04-11 | CAS: 142896-15-9

Tetrahedron Letters published new progress about Allylation. 142896-15-9 belongs to class esters-buliding-blocks, name is Methyl 2,6-dimethylisonicotinate, and the molecular formula is C9H11NO2, Quality Control of 142896-15-9.

Craig, Donald published the artcileSulfone-mediated synthesis of polysubstituted pyridines, Quality Control of 142896-15-9, the main research area is bisallylation alkyl tolylsulfonylacetate; pyridinecarboxylic ester preparation; ozonolysis ammonolysis bisallylated tolylacetic ester.

Base-mediated and/or palladium(0)-catalyzed bis(allylation) of alkyl 2-(tolylsulfonyl)acetates gives 1,6-dienes, which upon ozonolytic cleavage of the double bonds and ammonolysis give 2,6-disubstituted pyridine-4-carboxylic esters. Decarboxylation of one of the 1,6-diene intermediates followed by deprotonation-alkylation and ozonolysis-ammonolysis gives a 2,4,6-trisubstituted pyridine.

Tetrahedron Letters published new progress about Allylation. 142896-15-9 belongs to class esters-buliding-blocks, name is Methyl 2,6-dimethylisonicotinate, and the molecular formula is C9H11NO2, Quality Control of 142896-15-9.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics