On March 4, 1999, Hewawasam, Piyasena; Starrett, John E., Jr.; Swartz, Stephen G. published a patent.Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of 4-aryl-3-aminoquinoline-2-ones as potassium channel modulators. And the patent contained the following:
The title compounds [I; R, R1 = H, Me; R2-R4 = H, halo, NO2, CF3; R5 = H, alkyl, alkylsulfonyl, etc.; R6 = H, Br, Cl, NO2] which are modulators of the large conductance calcium-activated K+ channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels such as ischemia, stroke, convulsions, epilepsy, asthma, irritable bowel syndrome, migraine, traumatic brain injury, spinal cord injury, male erectile dysfunction, and urinary incontinence, were prepared Thus, demethylation of 3-amino-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one (preparation given) with BBr3 in CH2Cl2 afforded 97% I [R1 = H; R2 = R4 = H; R3 = CF3; R5 = H; R6 = Cl; RO = 2-OH] which showed > 150% increase over BK current in controls at 20 μM. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
The Article related to potassium channel modulator arylaminoquinolinone preparation, quinolinone arylamino preparation potassium channel modulator, ischemia arylaminoquinolinone preparation, stroke arylaminoquinolinone preparation, anticonvulsant arylaminoquinolinone preparation, antiasthmatic arylaminoquinolinone preparation, irritable bowel syndrome arylaminoquinolinone preparation and other aspects.Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
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