Category: 141940-37-6

Romero, Eugenie; Minard, Corinne; Benchekroun, Mohamed; Ventre, Sandrine; Retailleau, Pascal; Dodd, Robert H.; Cariou, Kevin published an article in 2017, the title of the article was Base-Mediated Generation of Ketenimines from Ynamides: Direct Access to Azetidinimines by an Imino-Staudinger Synthesis.Formula: C12H14F3NO2 And the article contains the following content:

Ynamides were used as precursors for the in situ generation of highly reactive ketenimines that could be trapped with imines in a [2+2] cycloaddition This imino-Staudinger synthesis led to a variety of imino-analogs of β-lactams, namely azetidinimines I [Ar1 = Ph, 4-MeOC6H4, 4-ClC6H4, 4-BrC6H4, 4-IC6H4, 4-F3CC6H4; Ar2 = Ph, 4-MeOC6H4, 4-ClC6H4, 4-BrC6H4, 4-IC6H4, 4-MeO2CC6H4, 4-t-Bu-O2CC6H4; Ar3 = Ph, 4-MeOC6H4] that could be further functionalized through a broad range of transformations. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2

The Article related to azetidinimine preparation, ketenimine insitu generation ynamide imine imino staudinger cycloaddition, staudinger synthesis, [2+2] cycloaddition, azetidinimines, ketenimines, ynamides and other aspects.Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 15, 2011, Zhu, Mingzhao; Zheng, Nan published an article.Category: esters-buliding-blocks The title of the article was Photoinduced cleavage of N-N bonds of aromatic hydrazines and hydrazides by visible light. And the article contained the following:

A photocatalytic system involving [Ru(bpyrz)3](PF6)2·2H2O, visible light, and air has been developed for cleavage of the N-N bonds of hydrazines and hydrazides. This catalytic system is generally effective for N,N-disubstituted hydrazine and hydrazide derivatives, including arylhydrazides, N-alkyl-N-arylhydrazines, and N,N-diarylhydrazines. The utility of this cleavage reaction has been demonstrated by synthesizing a variety of secondary aromatic amines. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Category: esters-buliding-blocks

The Article related to secondary aromatic amine synthesis electrophilic amination, aromatic hydrazine hydrazide photoinduced catalytic cleavage nitrogen light ruthenium, amines, cleavage, nitrogen–nitrogen bonds, ruthenium, visible light and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Wanqiao; Zhang, Ruzhong; Zhang, Ruxue; Yu, Jianxin; Wang, Mang published an article in 2022, the title of the article was Radical hydrotrifluoromethylation of ynamides: a route toward β-CF3 enamides.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate And the article contains the following content:

Radical hydrotrifluoromethylation of ynamides RNR2CCR1 (R = Ph, 3-chlorophenyl, benzodioxol-5-yl, etc.; R1 = H, cyclopropyl, Ph, etc.; R2 = Boc, Ac, Cbz) to provide an alternative route toward (E)-β-CF3 enamides RNR2CH=C(CF3)R1 was reported. By using PhICF3Cl as the CF3 reagent and DMF as the H-donor, the reaction occurred smoothly in the presence of NaH at room temperature Further reduction of the resulting β-CF3 enamides efficiently delivered β-CF3 amines RNHCH2CH(CF3)R1. Gram-scale synthesis was conducted to demonstrate the practicability of the method. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to aryl trifluoromethyl amine preparation, trifluoromethyl enamide preparation diastereoselective deprotection reduction reaction, ynamide chlorophenyl trifluoromethyliodane radical hydrotrifluoromethylation reaction and other aspects.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 17, 2020, Nagai, Takuya; Mimata, Nao; Terada, Yoshihiro; Sebe, Chikayoshi; Shigehisa, Hiroki published an article.Formula: C12H14F3NO2 The title of the article was Catalytic Dealkylative Synthesis of Cyclic Carbamates and Ureas via Hydrogen Atom Transfer and Radical-Polar Crossover. And the article contained the following:

Guided by the transition metal hydrogen atom transfer and radical-polar crossover concepts, a functional-group tolerant and scalable method for the synthesis of cyclic carbamates and ureas I [R1 = Ph, 4-ClC6H4, 4-MeCOC6H4CH2, etc.; R2 = H, Me; X = O, NTs, NNs; n = 1,2,3,4], which were found in the structures of bioactive compounds was developed. This method not only provided common five-membered ring but also six-to-eight-membered ring products. The reaction proceeded through the intramol. displacement of an alkylcobalt(IV) intermediate and dealkylation by 2,4,6-collidine, the activation energies of these steps were calculated by DFT. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2

The Article related to cyclic carbamate preparation, alkenyl carbamate dealkylative hydrogen transfer crossover cobalt complex catalyst, urea cyclic preparation, isourea alkenyl dealkylative hydrogen transfer crossover cobalt complex catalyst and other aspects.Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 27, 2002, Swenson, Rolf E.; Sowin, Thomas J.; Zhang, Henry Q. published an article.COA of Formula: C12H14F3NO2 The title of the article was Synthesis of Substituted Quinolines Using the Dianion Addition of N-Boc-anilines and α-Tolylsulfonyl-α,β-unsaturated Ketones. And the article contained the following:

A short and versatile synthesis of substituted quinolines is provided. Alkylation of sodium tolylsulfinate with bromomethyl- or chloromethyl ketones generates β-keto sulfones, e.g., I. Knoevenagel condensation of the β-keto sulfones with an aldehyde provides α-tolylsulfonyl-α,β-unsaturated ketones, e.g., II. Michael addition of the dianion of N-Boc-anilines in the presence of CuCN and LiCl with the unsaturated ketone generates a 1,4-adduct, which after deprotection of the Boc group and thermal elimination of the tolyl sulfone provides the quinoline, e.g., III. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).COA of Formula: C12H14F3NO2

The Article related to sodium tolylsulfinate halomethyl ketone alkylation, keto sulfone preparation aldehyde knoevenagel condensation, unsaturated ketone tolylsulfonyl preparation aniline dianion michael addition elimination, quinoline preparation and other aspects.COA of Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 28, 2013, Koreeda, Tetsuro; Kochi, Takuya; Kakiuchi, Fumitoshi published an article.Formula: C12H14F3NO2 The title of the article was Substituent Effects on Stoichiometric and Catalytic Cleavage of Carbon-Nitrogen Bonds in Aniline Derivatives by Ruthenium-Phosphine Complexes. And the article contained the following:

The reactivity of various o-acylaniline derivatives with Ru complexes was examined The reaction of o-acylanilines with RuH2(CO)(PPh3)3 (1) or an activated Ru species formulated as Ru(CO)(PPh3)3 (4) gave amido hydrido complexes 3 and aryl amido complexes, e.g., I (R = H, Me, OMe, F, CF3), formed via N-H and C-N bond cleavage, resp. Addition of olefins, such as vinylsilanes, accelerates the C-N bond cleavage. The aryl amido complexes I can provide the C-N arylation product upon treatment with arylboronates. The relative reactivity of o-acylanilines bearing various substituents was studied by competition experiments, and electron-donating substituents increase the relative facileness of the C-N bond cleavage in both stoichiometric and catalytic reactions. The trend observed here is different from the one observed for the previously reported Ta-mediated C-N bond cleavage. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2

The Article related to aniline catalytic stoichiometric carbon nitrogen bond cleavage hydridoruthenium phosphine, pivaloylaniline cyclometalation ruthenium hydride complex, ruthenium pivaloylanilido complex preparation catalyst arylation acylaniline and other aspects.Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 6, 2008, Sugita, Kazuyuki; Ohtsuka, Masami; Oki, Hitoshi; Haginoya, Noriyasu; Ichikawa, Masanori; Ota, Masahiro; Shibata, Yoshihiro published a patent.Product Details of 141940-37-6 The title of the patent was Preparation of tricyclic heteroaryl compounds as squalene synthetase inhibitors. And the patent contained the following:

There are disclosed 31 specific compounds such as 2-[(4R,6S)-8-chloro-6-(2-chloro-3-ethoxyphenyl)-1-(trifluoromethyl)-4H,6H-[1,2,4]triazolo[4,3-a][4,1]benzoxazepin-4-yl]acetic acid and (2) 2-(1-[2-[(4R,6S)-8-chloro-6-(2-chloro-3-ethoxyphenyl)-1-(trifluoromethyl)-4H,6H-[1,2,4]triazolo[4,3-a][4,1]benzoxazepin-4-yl]acetyl]-4-piperidinyl)acetic acid which have a squalene synthase inhibition activity and a cholesterol synthesis inhibition activity and are useful as medicinal agents such as prophylactic and/or therapeutic agents for hyperlipemia (including hypercholesterolemia, hypertriglyceridemia and hypo-HDL-cholesterolemia) and/or arteriosclerosis in a mammal including human. Thus, Et [trans-5-(2-bromo-3-methoxyphenyl)-7-chloro-2-thioxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetate was condensed with hydrazine hydrate in THF under ice-cooling for 30 min to give a hydrazone which was cyclocondensed with trifluoroacetic anhydride in dichloroethane first at room temperature for 2 h and then under refluxing for 2 h to give Et [trans-6-(2-bromo-3-methoxyphenyl)-8-chloro-1-(trifluoromethyl)-4H,6H-[1,2,4]triazolo[4,3-a][4,1]benzoxazepin-4-yl]acetate (I). Chromatog. resolution of I using a Chiralpak AD column and a 2:8 mixture of isopropanol and hexane as the eluent to give Et [(4R,6S)-6-(2-bromo-3-methoxyphenyl)-8-chloro-1-(trifluoromethyl)-4H,6H-[1,2,4]triazolo[4,3-a][4,1]benzoxazepin-4-yl]acetate (II) and Et [(4S,6R)-6-(2-bromo-3-methoxyphenyl)-8-chloro-1-(trifluoromethyl)-4H,6H-[1,2,4]triazolo[4,3-a][4,1]benzoxazepin-4-yl]acetate. II was stirred with a 4:1 mixture of AcOH and concentrated H2SO4 at 60° for 7 h to give [(4R,6S)-6-(2-bromo-3-methoxyphenyl)-8-chloro-1-(trifluoromethyl)-4H,6H-[1,2,4]triazolo[4,3-a][4,1]benzoxazepin-4-yl]acetic acid (III). III showed IC50 of 0.46 μM against squalene synthase and at 3 mg/kg in vivo inhibited by 98% the synthesis of cholesterol in the liver of rats after 1 h. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Product Details of 141940-37-6

The Article related to cholesterol synthesis inhibitor triazolobenzoxazepinylacetic acid preparation, tricyclic heteroaryl compound preparation squalene synthetase inhibitor, triazolobenzoxazepinylacetic acid preparation squalene synthetase inhibitor and other aspects.Product Details of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 19, 2005, Rajapakse, Hemaka A.; Young, Mary Beth; Zhu, Hong; Charlton, Samantha; Tsou, Nancy N. published an article.Related Products of 141940-37-6 The title of the article was Asymmetric synthesis of dihydroquinazolinones via directed ortho metalation and addition to tert-butanesulfinyl imines. And the article contained the following:

An asym. route to dihydroquinazolinones via the addition of ortho metalated substrates to tert-butanesulfinyl imines is reported. The scope of the nucleophile and electrophile components and the absolute stereochem. outcome are presented. This method was applied to the asym. synthesis of (+)-3,4-dihydro-4-phenyl-3-[1-(phenylmethyl)-4-piperidinyl]-2(1H)-quinazolinone [i.e., (+)-SM-154811 hydrochloride]. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Related Products of 141940-37-6

The Article related to quinazolinone sm 15811 asym synthesis metalation addition sulfinyl imine, propanesulfinamide carbamate metalation addition asym synthesis quinazolinone sm 15811, hiv reverse transcriptase inhibitor quinazolinone sm 15811 asym synthesis and other aspects.Related Products of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 23, 2021, Jiang, Yaqiqi; Li, Bao; Ma, Nana; Shu, Sai; Chen, Yujie; Yang, Shan; Huang, Zhibin; Shi, Daqing; Zhao, Yingsheng published an article.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was Photoredox-Catalyst-Enabled para-Selective Trifluoromethylation of tert-Butyl Arylcarbamates. And the article contained the following:

In this study, a light-promoted 4,5-dichlorofluorescein (DCFS)-enabled para-selective C-H trifluoromethylation of arylcarbamates using Langlois reagent was reported. The preliminary mechanistic study revealed that the activated organic photocatalyst coordinated with the arylcarbamate led to para-selective C-H trifluoromethylation. Ten-gram scale reaction performs well highlighting the synthetic importance of this new protocol. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to sodium triflinate tertiary butyl arylcarbamate dichlorofluorescein catalyst photochem trifluoromethylation, tertiary butyl trifluoromethylaryl carbamate preparation regioselective, photoirradiation, site selectivity, ten gram scale, trifluoromethylation and other aspects.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 15, 2000, Hewawasam, Piyasena; Starrett, John E., Jr. published a patent.Related Products of 141940-37-6 The title of the patent was Preparation of 3-substituted-4-arylquinolin-2-one derivatives as calcium-activated potassium (BK) channel openers. And the patent contained the following:

The title compounds (I) [wherein R and R1 = independently H or Me; R2, R3, and R4 = independently H, halogen, NO2, or CF3; R5 = Br, Cl, or NO2; R6 = H or F; R7 = Me, CRR1OH, CHO, C:NOH, COMe, or (un)substituted aryl; m = 0-1; n = 0-6] were prepared by cyclization and further reaction of 1-[2-(acylamino)phenyl]-1-phenylmethanone derivatives For example, 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-2(1H)-quinoline (II) was synthesized in a 5-step sequence starting with acylation of 1-[2-amino-5-(trifluoromethyl)phenyl]-1′-(5-chloro-2-methoxyphenyl)methanone (preparation given) with 3-carbomethoxypropionyl chloride (82%). Subsequent cyclization (100%), dehydration (78%), demethylation (86%), and reduction of the acid yielded II. II activated the cloned BK channel mSlo expressed in Xenopus oocytes, increasing whole cell outward (K+) BK-mediated currents > 200% at 20 μM. In an in vivo erectile function test on diabetic F-344 rats, II (0.1-1 mg/kg) significantly augmented intracavernous pressure/BP responses elicited by submaximal stimulation of the cavernous nerve. As BK channel openers, I are useful in the treatment of disorders which are responsive to the opening of the potassium channels, such as ischemia, stroke, convulsions, epilepsy, asthma, irritable bowel syndrome, migraine, traumatic brain injury, spinal cord injury, sexual dysfunction, and urinary incontinence. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Related Products of 141940-37-6

The Article related to arylquinolinone preparation potassium channel opener, quinolinone aryl preparation erectile dysfunction treatment, stroke treatment quinolinone aryl preparation, brain injury treatment quinolinone aryl preparation, sexual dysfunction quinolinone aryl preparation and other aspects.Related Products of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics