Category: 141940-37-6

On September 15, 2010, Wu, Yusheng; Zou, Dapeng; Li, Jingya; Guo, Ruiyun; Qin, Lijin; Cui, Hongmeng; Cui, Xiuling published a patent.COA of Formula: C12H14F3NO2 The title of the patent was Catalysis system for preparation of N-Boc arylamines. And the patent contained the following:

The catalysis system consists of Pd acetate, phosphine ligand XPhos and Cs carbonate at a mol. ratio 1:3:45-50. The preparation comprises adding Pd acetate, phosphine ligand XPhos, Cs carbonate, tertbutyl amino formate, aryl halide, and anhydrous dioxane at a mol. ratio 0.03:0.09:1.35-1.50:1.2:1:90-95 in a dry reactor, stirring, reacting at 100°C for 1.5-24 h in inert gas (nitrogen) protection, adding water after finishing reaction, extracting with Et acetate, combining organic phases, drying the combined organic phases, concentrating, and purifying. The aryl halide is aryl chloride, aryl bromide, heterogeneous aryl chloride or heterogeneous aryl bromide. The catalysis system can be used for preparation of N-Boc-arylamine compounds The invention has the advantages of mild condition, easy operation, simple post treatment, high yield, less environment pollution, etc.. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).COA of Formula: C12H14F3NO2

The Article related to arylamine butoxycarbonyl preparation aryl halide carbamate coupling catalyst palladium, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

van der Born, Dion; Sewing, Claudia; Herscheid, J. D. M.; Windhorst, Albert D.; Orru, Romano V. A.; Vugts, Danielle J. published an article in 2014, the title of the article was A Universal Procedure for the [18F]Trifluoromethylation of Aryl Iodides and Aryl Boronic Acids with Highly Improved Specific Activity.Category: esters-buliding-blocks And the article contains the following content:

Herein, we describe a valuable method for the introduction of the [18F]CF3 group into arenes with highly improved specific activity by the reaction of [18F]trifluoromethane with aryl iodides or aryl boronic acids. This [18F]trifluoromethylation reaction is the first to be described in which the [18F]CF3 products are generated in actual trace amounts and can therefore effectively be used as PET tracers. The method shows broad scope with respect to possible aryl iodide and aryl boronic acid substrates, as well as good to excellent conversion. In particular, the [18F]trifluoromethylation of boronic acids was found to outperform [18F]trifluoromethylation reactions of halogenated aryl precursors with regard to conversion, reaction conditions, and kinetics. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Category: esters-buliding-blocks

The Article related to arene preparation trifluoromethylation aryl iodide boronic acid, fluorine-18, isotopic labeling, radiochemistry, specific activity, trifluoromethylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Category: esters-buliding-blocks

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 2010, Nielsen, Simon Dalsgaard; Smith, Garrick; Begtrup, Mikael; Kristensen, Jesper Langgaard published an article.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was Amination of Aryl Iodides Using a Fluorous-Tagged Ammonia Equivalent. And the article contained the following:

A fluorous-tagged ammonia equivalent for the Cu-catalyzed amination of aryl iodides is described in which N-Boc-protected anilines are produced in high overall yield and purity. All purification steps are performed using Fluorous Solid-Phase Extraction (F-SPE) greatly simplifying and speeding up the isolation of the desired products. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to aryl iodide copper heptadecafluoroundecyloxy carbamic acid tertbutyl ester amination, aniline preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 6, 2021, Zhao, Yingsheng; Jiangya, Qiqi; Shi, Daqing published a patent.Application of 141940-37-6 The title of the patent was Preparation of aniline para-trifluoromethyl derivative. And the patent contained the following:

The present invention relates to the preparation of aniline para-trifluoromethyl derivative In particular, the preparation method comprises the following steps: (1) adding aniline derivative, 4,5-dichlorofluorescein, potassium persulfate and sodium trifluoromethyl sulfinate in a glass reaction tube, and using DMSO as a solvent to react at room temperature (23-25°) under a 40W blue LED to obtain aniline para-trifluoromethyl derivative, and (2) after the reaction is completed, the product is separated and purified by column chromatog. to obtain the para-trifluoromethylated aniline derivative The present invention has following advantages: (1) the raw material is readily available in many kinds; (2) the products obtained by the method of the present invention are of various types and can be directly applied to the modification of drug mols.; (3) at the same time, the synthetic route is safe and easy, the cost is low, the reaction operation and post-treatment process is simple, the selectivity is good, the side reactions are few, and the reaction can be scaled up. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Application of 141940-37-6

The Article related to trifluoromethyl sulfinate aniline photochem trifluoromethylation, aniline trifluoromethyl derivative preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Application of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 15, 2012, Ma, Fangfang; Xie, Xiaomin; Zhang, Lei; Peng, Zhiyong; Ding, Lina; Fu, Lei; Zhang, Zhaoguo published an article.Category: esters-buliding-blocks The title of the article was Palladium-catalyzed amidation of aryl halides using 2-dialkylphosphino-2′-alkoxyl-1,1′-binaphthyl as ligands. And the article contained the following:

Palladium-catalyzed intermol. C-N bond-forming reactions between aryl halides and amides are described using 2-dialkylphosphino-2′-alkoxyl-1,1′-binaphthyl, which is both bulky and electron-rich, as the ligand. A variety of amides, including aliphatic and aromatic primary amides, lactams, and carbamates, e. g., I, II and III were viable substrates for the amidation, which exhibited good functional group compatibility. By tuning the substituents at the 2,2′-position of 1,1′-binaphthyl of the ligand, the palladium-catalyzed amidation of bulky aryl halides was realized and this coupling reaction was used to synthesize 2-amino-2′-methoxy-1,1′-binaphthyl in high yield. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Category: esters-buliding-blocks

The Article related to amide preparation, aryl halide amide amidation pd binaphthyl ligand, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 18, 2010, Qin, Lijin; Cui, Hongmeng; Zou, Dapeng; Li, Jingya; Wu, Yangjie; Zhu, Zhiwu; Wu, Yusheng published an article.COA of Formula: C12H14F3NO2 The title of the article was Pd-catalyzed amidation of aryl(Het) halides with tert-butyl carbamate. And the article contained the following:

Pd-catalyzed cross-coupling reaction of tert-Bu carbamate with various aryl(Het) halides with Cs2CO3 as base in 1,4-dioxane as solvent was investigated, which resulted in the formation of the desired compounds in moderate to excellent yields. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).COA of Formula: C12H14F3NO2

The Article related to aryl carbamate preparation, butyl carbamate aryl halide amidation palladium, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.COA of Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 25, 2018, Wang, Mingliang; Han, Jilai; Si, Xiaojia; Hu, Yimin; Zhu, Jidong; Sun, Xun published an article.Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was Effective approach to ureas through organocatalyzed one-pot process. And the article contained the following:

An efficient approach to N,N’-unsym. substituted ureas ArN(R1)C(O)NH(R2) (R1 = H; R2 = n-Bu, c-hexyl, Bn, etc.; Ar = 4-MeC6H4, 4-MeOC6H4, 4-F3CC6H4, 3-BrC6H4) has been developed through the ammonolysis of N-Boc protected anilines with amines prompted by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD). Moreover, a convenient protocol for the synthesis of the sym. N,N’-substituted ureas RNHC(O)NHR (R = Ph, 2-ClC6H4, 4-IC6H4, etc.) by one-pot diammonolysis of Boc2O with amines catalyzed by DABCO has also been achieved. With broad substrate scope and mild conditions, these two methods demonstrate practical preparation of both unsym. and sym. ureas. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to unsym sym urea preparation, amine tert butyl dicarbonate ammonolysis diammonolysis triazabicyclodecene dabco catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 16, 2018, Reddy, Leleti Rajender; Kotturi, Sharadsrikar; Waman, Yogesh; Ravinder Reddy, Vudem; Patel, Chirag; Kobarne, Ajinath; Kuttappan, Sasikumar published an article.Electric Literature of 141940-37-6 The title of the article was N-Arylation of Carbamates through Photosensitized Nickel Catalysis. And the article contained the following:

A highly efficient method of visible light mediated Ni(II)-catalyzed photoredox N-arylation of Cbz-amines/Boc-amines with aryl electrophiles at room temperature is reported. The methodol. provides a common access to a wide variety of N-aromatic and N-heteroaromatic carbamate products that find use in the synthesis of several biol. active mols. and provides a distinct advantage over traditional palladium-catalyzed Buchwald reaction. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Electric Literature of 141940-37-6

The Article related to carbamate aryl bromide arylation nickel photolysis, arylcarbamate preparation, nickel photosensitized arylation catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Electric Literature of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 1992, Takagishi, Sadahito; Katsoulos, Georges; Schlosser, Manfred published an article.Formula: C12H14F3NO2 The title of the article was Fluorine and trifluoromethyl substituted anilines: site selective metalation and electrophilic substitution. And the article contained the following:

When treated with tert-butyllithium in THF at -50°, N-BOC (tert-butoxycarbonyl) protected fluoroanilines and trifluoromethylanilines, e.g., o-, m-, or p-F3CC6H4NHCO2CMe3, undergo metalation at the position adjacent to that carrying the nitrogen. If, however, the nitrogen carries two alkyl or trimethylsilyl groups as substituents and highly polar metalating reagents such as butyllithium activated by N,N,N’,N”,N”-pentamethyldiethylenetriamine (PMDTA) or potassium tert-butoxide are employed, the fluoroaniline derivatives are preferentially deprotonated next to the halogen atom. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2

The Article related to lithiation regioselective fluoroaniline, substituent effect lithiation fluoroaniline, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 21, 2010, Uchida, Hideharu; Ogawa, Shinichi; Makabe, Muneyoshi; Maeda, Yoshitaka published a patent.Related Products of 141940-37-6 The title of the patent was Preparation of heterocyclylidene-N-(heterocyclyl)acetamide derivatives as antagonists of transient receptor potential type I receptor (TRPV1). And the patent contained the following:

The title compounds [I; k, m, n, p = 0-2; j, q = 0-1; R1 = halo, H, heterocyclyl, alkoxy, alkoxycarbonyl, NH2, OH, CO2H, alkanoyl, cyano, NO2, etc.; R2 = halo, NH2, alkyl, aromatic heterocyclyl, oxo, etc.; X1 = O, NR3, or S(O)r; X2 = CH2, O, NR3, S(O)r (wherein r = 0-2; R3 = H, alkyl, heterocyclyl, etc.); W = CH2, CO, SO2; R7 = H, alkyl, heterocyclyl, etc.; R8 = H, halo, alkyl, heterocyclyl, etc.; a dashed line in the ring containing X1 and X2 means the fusion of two rings; L1, L2 = a single bond, (un)substituted CH2 or NH, S(O)t (t = 0-2); the “”Cycle”” moiety represents a 5-6 membered aryl or heteroaryl ring; a solid line and a dashed line between L1 and L2 mean the presence of a single bond and a double bond, resp.; and a wavy line means an E-form or Z-form], or salts thereof, or solvates of the compounds or the salts, useful as antagonists of transient receptor potential type I receptor (TRPV1), were prepared Thus, (E)-(8-trifluoromethyl-3,4-dihydro-2H-benzo[b]oxepin-5-ylidene)acetic acid was stirred with oxalyl chloride and one drop of DMF in CH2Cl2 at room temperature for 2 h, concentrated under reduced pressure, redissolved in CH2Cl2, and stirred with 6-amino-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one at room temperature for 2 h to give (E)-2-(8-Trifluoromethyl-3,4-dihydrobenzo[b]oxepin-5(2H)-ylidene)-N-(2,2-dimethyl-3-oxo-2,3-dihydro-4H-benzo[1,4]oxazin-6-yl)ethanamide (II). II in vitro at <100 nM inhibited the capsaicin-induced cellular influx of calcium in CHO cells genetically transformed with human TRPV1. Pharmaceutical formulations, e.g. a tablet containing II, were described. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Related Products of 141940-37-6

The Article related to trpv1 antagonist heterocyclylideneheterocyclylacetamide preparation, heterocyclylideneheterocyclylacetamide preparation antagonist transient receptor potential type i receptor and other aspects.Related Products of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics