Category: 141940-37-6

On September 16, 2004, Gonzales, Jesus E., III; Wilson, Dean Mitchell; Termin, Andreas Peter; Grootenhuis, Peter Diederik Jan; Zhang, Yulian; Petzoldt, Benjamin John; Fanning, Lev Tyler Dewey; Neubert, Timothy Donald; Tung, Roger D.; Martinborough, Esther; Zimmermann, Nicole published a patent.Related Products of 141940-37-6 The title of the patent was Preparation of quinazolines as modulators of ion channels. And the patent contained the following:

The title compounds [I; NR1R2 = (un)substituted 3-12 membered monocyclic or bicyclic (un)saturated ring having 0-3 heteroatoms selected from N, S or O; ring A = (un)substituted 5-7 membered aryl or 8-10 membered bicyclic aryl having 0-3 heteroatoms selected from N, S or O; x = 0-4; R3 = QR (wherein Q = a bond, alkylidene wherein up to two non-adjacent methylene units are optionally replaced by S, O, CS, etc.; R = halo, NO2, CN, etc.)], useful as inhibitors of voltage-gated sodium channels and calcium channels, were prepared Thus, reacting 2-(4-chloro-7-methylquinazolin-2-yl)phenol with 4-aminopiperidine in the presence of Et3N in CH2Cl2 afforded 89% II. Representative compounds I were found to possess desired N-type calcium channel modulation activity and selectivity (no specific data given). Also, representative compounds I were found to possess desired voltage gated sodium channel activity and selectivity (no specific data given). The invention also provides pharmaceutically acceptable compositions comprising the compounds I and methods of using the compositions in the treatment of various disorders. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Related Products of 141940-37-6

The Article related to quinazoline preparation modulator sodium calcium ion channel, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Related Products of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 9, 2003, Basarab, Gregory; Eyermann, Joseph; Gowravaram, Madhusudhan; Green, Oluyinka; MacPherson, Lawrence; Morningstar, Marshall; Nguyen, Thanh published a patent.HPLC of Formula: 141940-37-6 The title of the patent was Preparation of pyrazolo[3,4-d]pyrimidines for inhibiting H. pylori infections. And the patent contained the following:

Title compounds I [wherein R1 and R2 = independently H, NH2, or (un)substituted (cyclo)alkyl, (cyclo)alkenyl, alkynyl, aryl, alkoxy, or heterocyclyl; R3 = (un)substituted monocyclic or bicyclic ring system comprising 0-3 heteroatoms independently selected from N, O, or S; R4 = (un)substituted alkyl or (di)alkylamino, with exceptions; Y = CH2, CHCH3, SO, or SO2; and pharmaceutically acceptable salts thereof] were prepared For example, 6-hydrazino-1-isobutyl-3-methylpyrimidine-2,4-(1H,3H)-dione (4-step preparation given) was condensed with 1-naphthaldehyde in MeOH to give the hydrazone. Cyclocondensation with N-(4-formylphenyl)acetamide in DMF afforded II. Compounds of the invention exhibited glutamate racemase (MurI) activity with IC50 values of < 400 μM. Thus, I and pharmaceutical compositions containing them are useful in the treatment or prophylaxis of Helicobacter pylori (H. pylori) infection (no data). The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).HPLC of Formula: 141940-37-6

The Article related to pyrazolopyrimidine preparation antibacterial helicobacter pylori, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.HPLC of Formula: 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 28, 2006, Gonzalez, Jesus E.; Wilson, Dean M.; Termin, Andreas P.; Grootenhuis, Peter D. J.; Zhang, Yulian; Petzoldt, Benjamin J.; Fanning, Lev Tyler Dewey; Neubert, Timothy D.; Tung, Roger D.; Martinborough, Esther; Zimmerman, Nicole published a patent.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of quinazolines as modulators of ion channels. And the patent contained the following:

The title compounds [I; NR1R2 = (un)substituted 3-12 membered monocyclic or bicyclic (un)saturated ring having 0-3 heteroatoms selected from N, S or O; ring A = (un)substituted 5-7 membered aryl, 8-10 membered bicyclic aryl having 0-3 heteroatoms selected from N, S or O, etc.; x = 0-4; R3 = QR (wherein Q = a bond, alkylidene wherein up to two non-adjacent methylene units are optionally replaced by S, O, CS, etc.; R = halo, NO2, CN, etc.); with provisos], useful as inhibitors of voltage-gated sodium channels and calcium channels, were prepared Thus, reacting 2-(4-chloro-7-methylquinazolin-2-yl)phenol with 4-aminopiperidine in the presence of Et3N in CH2Cl2 afforded 89% II. Representative compounds I were found to possess desired N-type calcium channel modulation activity and selectivity (no specific data given). Also, representative compounds I were found to possess desired voltage gated sodium channel activity and selectivity (no specific data given). The invention also provides pharmaceutically acceptable compositions comprising the compounds I and methods of using the compositions in the treatment of various disorders. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to quinazoline preparation modulator sodium calcium ion channel analgesic, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 16, 2021, Cleary, Leah; Fleury, Melissa; Pei, Zhonghua published a patent.Computed Properties of 141940-37-6 The title of the patent was Preparation of quinolinone derivatives as methionine adenosyltransferase 2a inhibitors for treatment of cancer. And the patent contained the following:

Disclosed herein are certain quinolinone derivatives of I that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Compounds of formula I [wherein V = Ph or 5 to 6 membered heteroaryl; Z = CH or N; R1, R2, and R5 independently = H, cyano, halo, C1-6alkyl, etc.; each R3 independently = halo, C1-4alkyl, C1-4haloalkyl, etc.; R4 = H, halo, C1-6alkyl, C6-10aryl, etc.; Y2 = bond or C1-4alkylene; n = 0, 1, or 2] or pharmaceutically acceptable salts thereof, are claimed and exemplified. Example compound II was prepared from a multistep procedure (preparation given). Exemplified I were evaluated for MAT2A inhibitory activity from which II exhibited an IC50 in the range of �10 nM to < 200 nM. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Computed Properties of 141940-37-6

The Article related to quinolinone derivative preparation methionine adenosyltransferase 2a inhibitor cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 18, 2009, Nicolaou, K. C.; Krasovskiy, Arkady; Majumder, Utpal; Trepanier, Vincent E.; Chen, David Y.-K. published an article.Related Products of 141940-37-6 The title of the article was New Synthetic Technologies for the Construction of Heterocycles and Tryptamines. And the article contained the following:

New synthetic methods for the construction of novel heterocycles and tryptamines are described. Thus, N-Boc anilines are sequentially converted to (3-(2-aminophenyl)pyrrolidin-3-ol) derivatives, substituted 2-oxo-1,2-dihydrospirobenzo[d][1,3]oxazine-4,3′-pyrrolidines, and 2-(4,5-dihydro-1H-pyrrol-3-yl)aniline derivatives through a route involving t-BuLi induced ortho-metalation/LaCl3·2LiCl metal exchange, reaction with N-Boc pyrrolidin-3-one, and subsequent decarboxylative fragmentation. Labile intermediates 2-(4,5-dihydro-1H-pyrrol-3-yl)anilines are effectively converted to tryptamines under controlled protic acid conditions. In addition to providing expedient access to the 2-oxo-1,2-dihydrospirobenzo[d][1,3]oxazine-4,3′-pyrrolidines, the method is applicable to the synthesis of the corresponding 2-oxo-1,2-dihydrospirobenzo[d][1,3]oxazine-4,3′-piperidine series of spirocycles and their precursors 3-(2-aminophenyl)piperidin-3-ol derivatives by using N-Boc-protected piperidin-3-one. Applications of the developed synthetic technologies to the synthesis of regioisomeric spirocycles, tryptamines, Corey’s aspidophytine tryptamine, and efavirenz are also described. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Related Products of 141940-37-6

The Article related to spiroheterocycle tryptamine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Related Products of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 29, 2015, Lim, Yeon-Hee; Guo, Zhuyan; Ali, Amjad; Edmondson, Scott D.; Liu, Weiguo; Gallo-Etienne, Gioconda V.; Wu, Heping; Gao, Ying-Duo; Stamford, Andrew M.; Yu, Younong; Kevin, Nancy J.; Anand, Rajan; Sha, Deyou; Neelamkavil, Santhosh F.; Hussain, Zahid; Kumar, Puneet; Moningka, Remond; Duffy, Joseph L.; Xu, Jiayi; Jiang, Yu; Sone, Hiroki; Chakrabarti, Anjan published a patent.Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of spiropyridooxazinepyrrolidine compounds as factor XIa inhibitors. And the patent contained the following:

The invention provides a compounds of formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective factor XIa inhibitors or dual inhibitors of factor XIa and plasma kallikrein. Compounds of formula I wherein Y1 – Y4 are independently CR4 and N; Z is S, SO, SO2 and CO; L is a bond, CONH, NHCO, etc.; M is (un)substituted aryl, heteroaryl, CH2, etc.; R1a is H, halo, CN, etc.; R1b is H, CN, OH, etc.; R2 is H, CN, halo, etc.; each R3 is independently H, halo, CN, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). Example compounds of the invention were tested in an assay to measure effectiveness as inhibitors of human factor XIa and plasma kallikrein. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to spiropyridooxazinepyrrolidine compound preparation factor xia inhibitor kallikrein therapy, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 1, 1994, Iwao, Masatomo published an article.Computed Properties of 141940-37-6 The title of the article was A new method for the construction of indole nucleus. And the article contained the following:

Directed lithiation of N-tert-butoxycarbonylanilines I (X = H, Y = H, F, MeO; X = Me, CF3, MeO, Cl, F, Y = H) and subsequent reaction with 1-tert-butyldimethylsilyl-1-phenylsulfinylethene gave the conjugate addition products which, without isolation, were cyclized to 1-tert-butoxycarbonyl-2-(phenylthio)indolines II under thermal sila-Pummerer reaction conditions. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Computed Properties of 141940-37-6

The Article related to indole, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nicolaou, K. C.; Krasovskiy, Arkady; Trepanier, Vincent E.; Chen, David Y.-K. published an article in 2008, the title of the article was An expedient strategy for the synthesis of tryptamines and other heterocycles.Category: esters-buliding-blocks And the article contains the following content:

N-Boc-protected anilines are converted into an array of useful N-heterocycles and tryptamines through an expedient, cascade-based synthetic sequence involving ortho metalation and subsequent coupling with N-Boc-pyrrolidin-3-one. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Category: esters-buliding-blocks

The Article related to tryptamine preparation protected aniline pyrrolidinone, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 8, 2021, D’Hollander, Agathe C. A.; Romero, Eugenie; Vijayakumar, Kamsana; Le Houerou, Camille; Retailleau, Pascal; Dodd, Robert H.; Iorga, Bogdan I.; Cariou, Kevin published an article.Electric Literature of 141940-37-6 The title of the article was Base-Mediated Generation of Ketenimines from Ynamides: [3+2] Annulation with Azaallyl Anions. And the article contained the following:

Ynamides was underwent a [3+2] cycloaddition with 2-azaallyl anions, obtained from benzylimines under the basic conditions and heat was reported. This reaction between two highly reactive intermediates, both generated in situ from bench stable starting materials, gave access to various nitrogen-rich heterocycles. The reaction usually proceeded with excellent diastereoselectivity, in favor of the cis adduct. Deuteration experiments and DFT calculations helped rationalize the regio- and stereoselectivity of the process as well as the formation of side products. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Electric Literature of 141940-37-6

The Article related to alkynamide enamine zinc acetate regioselective diastereoselective cycloaddition reaction, imidazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Electric Literature of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 17, 2020, Qian, Shengyou; Pu, Xingwen; Chang, Guanjun; Huang, Ying; Yang, Yudong published an article.SDS of cas: 141940-37-6 The title of the article was Rh(III)-catalyzed oxidative C-H activation/domino annulation of anilines with 1,3-diynes: a rapid access to blue-emitting tricyclic N,O-heteroaromatics. And the article contained the following:

Disclosed herein is a rhodium-catalyzed oxidative C-H activation/domino annulation of N-Boc-anilines with 1,3-diynes for the construction of tricyclic N,O-heteroaromatics This reaction features easily available substrates, mild reaction conditions, high regioselectivity, mono/diannulation selectivity, and intra/intermol. annulation selectivity. Moreover, this synthetic protocol enables the rapid assembly of a library of blue-emitting mols. with high quantum yields, among of which two fluorophores with pure blue-emission in toluene are discovered. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).SDS of cas: 141940-37-6

The Article related to rhodium catalysis oxidative anilines diyne tricyclic blue emitting heteroaromatic, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Other Dyes and Pigments and other aspects.SDS of cas: 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics