Category: 141940-37-6

Ieawsuwan, Winai; Ruchirawat, Somsak published an article in 2019, the title of the article was An efficient silver tetrafluoroborate-catalyzed cycloisomerization of ynamides.Synthetic Route of 141940-37-6 And the article contains the following content:

A silver catalyzed-cycloisomerization of N-Boc protected ynamides was developed under mild reaction conditions to provide a wide range of oxazolones I [R1 = (CH2)8OTIPS, Ph, 4-FC6H4, etc.; R2 = Ph, 4-ClC6H4, (CH2)2Ph, etc.] in good to excellent yields. Moreover, the acid-promoted Pictet-Spengler cyclization of oxazolones I was described to furnish the corresponding trans-oxazolidones II [R3 = H, OMe; R4 = R5 = OMe] in moderate yields. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Synthetic Route of 141940-37-6

The Article related to oxazolidone preparation diastereoselective, oxazolone preparation pictet spengler cyclization acid mediated, protected ynamide cycloisomerization silver catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Synthetic Route of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 3, 1998, Hardy, Jean-claude; Bouquerel, Jean; Nemecek, Patrick; Aloup, Jean-claude; Mignani, Serge; Peyronel, Jean-francois published a patent.Application of 141940-37-6 The title of the patent was Preparation of 2-iminothiazolo[5,4,3-ij]quinolines and analogs as glutamatergic antagonists. And the patent contained the following:

Title compounds [I; R1 = H or alkyl; R6 = fluoroalkyl, -alkoxy, -alkylthio; R7 = H or alkyl, CH2OH, CH2NH2, alkylsulfonylmethyl, etc. only when Z = CH2CH2; Z = CH2CH2, CH(OH)CF2, COCH2, SO0-2CH2, etc.; Z1 = S or Se] were prepared Thus, 4-(F3CO)C6H4NH2 was cyclocondensed with HOCH(CH2OH)2 and the hydrogenated product cyclocondensed with KCNS to give I (R2 = R7 = H, R6 = OCF3, Z = CH2CH2, Z1 = S). Data for biol. activity of I were given. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Application of 141940-37-6

The Article related to iminothiazoloquinoline preparation glutamatergic antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 4, 1999, Hardy, Jean-Claude; Bouquerel, Jean; Nemecek, Patrick; Peyronel, Jean-Francois published a patent.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of thiazolobenzazepines and analogs as anticonvulsants and glutamate antagonists. And the patent contained the following:

Title compounds [I; R2 = H or alkyl; R6R3 = (CH2)4, (CH2)3CO, (CH2)3O, etc.; R7 = polyfluoroalkyl(oxy); Z = S or Se] were prepared Thus, N-protected Et 2-amino-5-trifluoromethoxybenzoate was N-alkylated by Br(CH2)3CO2Et and the product cyclized to give, in 3 addnl. steps, benzazepine II which was cyclocondensed with KSCN to give I [R2 = H, R6R3 = CH(OH)(CH2)3, R7 = OCF3, Z = S]. Data for biol. activity of I were given. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to thiazolobenzazepine preparation anticonvulsant glutamate antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 22, 2010, Sugita, Kazuyuki; Ota, Masahiro published a patent.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors. And the patent contained the following:

Title compounds, e.g., I [or their pharmacol. acceptable salts], etc., were prepared For example, reaction of Et [(trans)-7-chloro-5-[3-methoxy-2-(trifluoromethyl)phenyl]-2-thioxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetate (preparation given) with NH2NH2·H2O followed by cyclization with trifluoroacetic anhydride, separation using chiral HPLC and hydrolysis afforded (4R,6R)-I. In squalene synthase inhibition assays, the IC50 value of (4R,6R)-I was 0.88 nM. The invention compounds are claimed useful for the treatment of hypercholesterolemia, hyperlipidemia, etc. Pharmaceutical composition comprising (4R,6R)-I is disclosed. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to tricyclic heteroaryl preparation squalene synthase inhibitor, hypercholesterolemia hyperlipidemia treatment tricyclic heteroaryl preparation squalene synthase inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 8, 2010, Sugita, Kazuyuki; Otsuka, Masaki; Oki, Hitoshi; Haginoya, Noriyasu; Ichikawa, Masanori; Ota, Masahiro; Shibata, Norihiro published a patent.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors. And the patent contained the following:

Title compounds, e.g., I [or pharmaceutically acceptable salts or solvates thereof], etc., were prepared For example, reaction of compound II (preparation given) with NH2NH2·H2O followed by in-situ treatment with trifluoroacetic anhydride, de-allylation, ethylation, and hydrolysis afforded compound I. In squalene synthase inhibition assays, the IC50 of I was 0.98 nM. The invention compounds are claimed useful for the treatment of hypercholesterolemia, hyperlipidemia, etc. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to tricyclic heteroaryl preparation squalene synthase inhibitor, hypercholesterolemia hyperlipidemia treatment tricyclic heteroaryl preparation squalene synthase inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 6, 2010, Sugita, Kazuyuki; Otsuka, Masaki; Oki, Hitoshi; Haginoya, Noriyasu; Ichikawa, Masanori; Ota, Masahiro; Shibata, Norihiro published a patent.Formula: C12H14F3NO2 The title of the patent was Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors. And the patent contained the following:

Title compounds, e.g., I [or pharmaceutically acceptable salts or solvates thereof], etc., were prepared For example, reaction of compound II (preparation given) with NH2NH2·H2O followed by in-situ treatment with trifluoroacetic anhydride, de-allylation, ethylation, and hydrolysis afforded compound I. In squalene synthase inhibition assays, the IC50 of I was 0.98 nM. The invention compounds are claimed useful for the treatment of hypercholesterolemia, hyperlipidemia, etc. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2

The Article related to tricyclic heteroaryl preparation squalene synthase inhibitor, hypercholesterolemia hyperlipidemia treatment tricyclic heteroaryl preparation squalene synthase inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 17, 2005, Mutti, Stephane; Malpart, Joel; Lavigne, Michel published a patent.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Method for preparation of thiazolo[3,4,5-de][4,1]benzothiazepines via direct cyclization of tert-butyl 2-hydroxymethylphenylcarbamates with thioglycolic acid in the presence of p-toluenesulfonic acid. And the patent contained the following:

The invention is related to the preparation of the well-known anticonvulsants thiazolo[3,4,5-de][4,1]benzothiazepine derivatives, in particular I•MeSO3H and II•MeSO3H, and their enantiomers and pharmaceutically acceptable salts via direct cyclization of 2-hydroxymethyl phenylcarbamates, e.g. tert-Bu 2-hydroxymethylphenylcarbamate (III) with thioglycolic acid (IV) in the presence of p-toluenesulfonic acid. The advantages include reduced number of steps and simple purification Thus, was prepared, in 58% global yield, in 8 steps: (1) BOC-protection of 4-trifluoromethylaniline with di-tert-Bu dicarbonate; (2) formylation with DMF; (3) reduction of the aldehyde with NaBH4; (4) cyclization of III with IV in the presence of p-toluenesulfonic acid in toluene; (5) reduction of amide V with NaBH4 in the presence of MeSiCl/THF; (6) cyclization of tetrahydrobenzothiazepine with KSCN in the presence of Br2/AcOH; (7) oxidation of thiazolobenzothiazepine with O3 in CH3CN/H2O; (8) methanesulfonate formation by treatment with MeSO3H in acetone/H2O. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to thiazolobenzothiazepine preparation cyclization hydroxymethylphenylcarbamate thioglycolic acid toluenesulfonic acid catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 15, 2010, Sugita, Kazuyuki; Haginoya,noriyasu published a patent.COA of Formula: C12H14F3NO2 The title of the patent was Preparation of substituted tricyclic heteroaryl compound as squalene and cholesterol synthetase inhibitors. And the patent contained the following:

Title compounds represented by the formula I [wherein R1 = (halo)alkoxy; R2 = halo, (halo)alkyl or alkoxy; R3 = halo, (halo)alkyl or (halo)alkoxy; R4 = hydroxyhaloalkyl; m = 0-4; -X-Y- = a single bond, alkylenecarbonyl-heterocyclyl or alkylene-heterocyclyl; and pharmaceutically acceptable salts thereof] were prepared as squalene and cholesterol synthetase inhibitors. For example, II was provided in a multi-step synthesis starting from 2-bromo-3-hydroxybenzaldehyde. I were tested for inhibition of rat squalene synthetase and rat liver cholesterol synthetase, e.g. II had an IC50 value of 1.7 nM on squalene synthetase and 84% inhibition rate on cholesterol synthetase. Thus, I are useful as squalene and cholesterol synthetase inhibitors for the treatment of hyperlipemia including hypercholesterolemia, hypertriglyceridemia and hypo-HDL cholesterolemia and/or arteriosclerosis in mammals including human. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).COA of Formula: C12H14F3NO2

The Article related to triazolobenzoxazepine preparation squalene cholesterol synthetase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.COA of Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 8, 2004, Polisetti, Dharma Rao; Kodra, Janos Tibor; Lau, Jesper; Bloch, Paw; Valcarce-Lopez, Maria Carmen; Blume, Niels; Guzel, Mustafa; Santhosh, Kalpathy Chidambareswaran; Mjalli, Adnan M. M.; Andrews, Robert Carl; Subramanian, Govindan; Ankersen, Michael; Vedso, Per; Murray, Anthony; Jeppesen, Lone published a patent.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of thiazolyl aryl ureas as activators of glucokinase. And the patent contained the following:

The title compounds [I; A1 = arylene, heteroarylene, fused cycloalkylarylene, etc.; L1 = a bond, O, S, SO, etc.; G1 = alkyl, cycloalkyl, cycloalkylalkylene, etc.; L2 = a bond, alkylene, alkenylene, etc.; L3 = CO, COCO, COCH2CO, SO2; R1 = alkyl, alkenyl, alkynyl, etc.; G2 = heteroaryl, fused heterocyclylheteroaryl, cycloalkylheteroaryl, etc.] which are activators of glucokinase and may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial (no data), were prepared and formulated. Thus, reacting 2-phenoxyaniline with 2-aminothiazole and 1,1′-carbonyldiimidazole afforded 95% the urea II. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to thiazolyl aryl urea preparation formulation glucokinase activator antidiabetic and other aspects.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 8, 2011, Nagib, David A.; MacMillan, David W. C. published an article.COA of Formula: C12H14F3NO2 The title of the article was Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis. And the article contained the following:

A simple and mild strategy for the direct trifluoromethylation of unactivated arenes and heteroarenes that acts via a radical-mediated mechanism and uses com. photocatalysts. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).COA of Formula: C12H14F3NO2

The Article related to arene heteroarene photoredox catalyst trifluoromethylation, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.COA of Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics