Category: 141940-37-6

On May 1, 2014, Patane, Michael published a patent.Product Details of 141940-37-6 The title of the patent was Compositions and methods for treating or preventing diseases or disorders associated with misregulated eIF-4E. And the patent contained the following:

Disclosed herein are compounds, compositions, formulations, kits and methods of treatment useful for treating or preventing one or more hyperproliferative disorders, e.g., cancer or a neurol. disease or disorder. Compounds of formula I wherein each R1 is independently (halo)alkyl, Cl, etc.; R2 is OH, NH2, aryl, etc.; R3 is H, alkyl, halo, etc; R4 is (un)substituted aryl, etc.; are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their anti-proliferative activity (some data given). The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Product Details of 141940-37-6

The Article related to thiazolylpyrazole preparation hyperproliferative cancer neurol eif4e, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Product Details of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 1, 2015, Patane, Michael published a patent.Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Compositions and methods for treating or preventing diseases or disorders associated with misregulated eif4e. And the patent contained the following:

Disclosed herein are compounds, compositions, formulations, kits and methods of treatment useful for treating or preventing one or more hyperproliferative disorders, e.g., cancer or a neurol. disease or disorder. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to thiazolylpyrazole preparation hyperproliferative cancer neurol eif4e, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 15, 2009, Degnan, Andrew P.; Tora, George O.; Denhart, Derek J.; Vrudhula, Vivekananda M.; Macor, John E.; Bronson, Joanne J. published a patent.Formula: C12H14F3NO2 The title of the patent was Preparation of substituted heterocyclic ethers as inhibitors of NK-1 and SERT and their use in treating CNS disorders. And the patent contained the following:

The invention encompasses compounds of Formula I (wherein R1 is H or alkyl; R2 is H, alkyl, cyanoalkyl, haloalkyl, etc.; R3 is H or alkyl; Ar1 is substituted Ph or pyridinyl; Ar2 is substituted indolyl, indazolyl, benzimidazolyl, or benzotriazolyl), including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders. The compounds of Formula I demonstrate inhibition of neurokinin-1 or serotonin reuptake or both and can be used therefore to treat conditions associated with aberrant levels of tachykinins or serotonin or both. Such conditions are anxiety, depression, obsessive compulsive disorder, bulimia, panic disorder, posttraumatic stress disorder, alc. dependence, or urinary incontinence. Synthetic procedures for preparing I are exemplified. Example compound II, prepared by removing the protecting groups from the corresponding intermediate, had an NK-1 and SERT IC50 values of 0.01-100 nM in binding assays. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2

The Article related to preparation heterocyclic ether nk1 sert inhibitor cns disorder treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 15, 2009, Degnan, Andrew P.; Tora, George O.; Denhart, Derek J.; Vrudhula, Vivekananda M.; Macor, John E.; Bronson, Joanne J. published a patent.Synthetic Route of 141940-37-6 The title of the patent was Preparation of substituted heterocyclic ethers as inhibitors of NK-1 and SERT and their use in treating CNS disorders. And the patent contained the following:

The invention encompasses compounds of Formula I (wherein R1 is H or alkyl; R2 is H, alkyl, cyanoalkyl, haloalkyl, etc.; R3 is H or alkyl; Ar1 is substituted Ph or pyridinyl; Ar2 is substituted indolyl, indazolyl, benzimidazolyl, or benzotriazolyl), including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders. The compounds of Formula I demonstrate inhibition of neurokinin-1 or serotonin reuptake or both and can be used therefore to treat conditions associated with aberrant levels of tachykinins or serotonin or both. Such conditions are anxiety, depression, obsessive compulsive disorder, bulimia, panic disorder, posttraumatic stress disorder, alc. dependence, or urinary incontinence. Synthetic procedures for preparing I are exemplified. Example compound II, prepared by removing the protecting groups from the corresponding intermediate, had an NK-1 and SERT IC50 values of 0.01-100 nM in binding assays. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Synthetic Route of 141940-37-6

The Article related to preparation heterocyclic ether nk1 sert inhibitor cns disorder treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Synthetic Route of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 18, 2012, Roosen, Philipp C.; Kallepalli, Venkata A.; Chattopadhyay, Buddhadeb; Singleton, Daniel A.; Maleczka, Robert E.; Smith, Milton R. published an article.Category: esters-buliding-blocks The title of the article was Outer-Sphere Direction in Iridium C-H Borylation. And the article contained the following:

The NHBoc group affords ortho selective C-H borylations in arenes and alkenes. Exptl. and computational studies support an outer sphere mechanism where the N-H proton H bonds to a boryl ligand O. The regioselectivities are unique and complement those of directed ortho metalations. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Category: esters-buliding-blocks

The Article related to iridium catalyzed borylation arene alkene regiochem, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 4, 2019, Wang, Zesheng; Cong, Xin; He, Guangwen; Liu, Chao; Dong, Ke; Wang, Peng; Cui, Qian; Yu, Yanbing published a patent.Category: esters-buliding-blocks The title of the patent was Preparation method of iodophosphine oxide ligand, complex and catalyst system comprising the iodophosphine oxide ligand, and application of the catalyst system. And the patent contained the following:

The invention discloses a preparation method of an iodophosphine oxide ligand, a complex comprising the iodophosphine oxide ligand, a catalyst system comprising the complex, and application of the catalyst system in the preparation of isocaprylic acid by oxidizing isooctyl aldehyde. The iodophosphine oxide ligand has a structural formula I as shown in claim 1, wherein in R1-R10 are independently selected from electron-withdrawing functional group of CF3, F and Br, or electron-donating functional group of CH3, OCH3 and CH(CH3)3; and preferably, R1 = R4, R2 = R3, R6 = R9, R8 = R5, and R7 = R10. The catalyst system adopts the iodophosphine oxide ligand and cesium complex as the catalyst, and a potassium salt as a co-catalyst, and was used for preparing isocaprylic acid by oxidizing isooctyl aldehyde. The inventive preparation method can overcome the defect of poor selectivity in prior art, and has mild process. The ligand has simple preparation, high activity, and low using amount The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Category: esters-buliding-blocks

The Article related to iodo aryl phosphine oxide ligand preparation oxidation catalyst, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 29, 2011, Brooks, Carl A.; Cheung, Mui; Eidam, Hilary S.; Fox, Ryan M.; Hilfker, Mark A.; Manas, Eric S.; Ye, Guosen published a patent.Recommanded Product: 141940-37-6 The title of the patent was 4-Quinolinecarboxamide derivatives as TRPV4 antagonists and their preparation and use for the treatment of diseases. And the patent contained the following:

The invention relates to 4-quinolinecarboxamide derivatives of formula I, which are TRPV4 antagonists and which are useful in the treatment of diseases. Compounds of formula I wherein R1 is C1-6 alkyl and C3-6 cycloalkyl; each R2 is independently OH, C1-4 alkoxy, C1-4 alkyl, etc.; R3 is (un)substituted morpholinyl, (un)substituted piperidinyl, (un)substituted pyrrolidinyl, etc.; each R4 is independently CF3, halo, C1-3 alkyl and C1-3 alkoxy; each R5 is independently (un)substituted 2-oxopyrrolidin-1-yl, halo, CN, etc.; two adjacent R5 taken together to form OCH2O and O(CH2)2O; each R6 is independently halo, Me and methoxy; X is N and CH; each n is independently 0 to 2; each p is independently 0 to 2; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their TRPV4 antagonistic activity. From the assay, it was determined that all compounds exhibited IC50 values in the range from 1 nM to 10 μM. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: 141940-37-6

The Article related to quinolinecarboxamide preparation trpv4 antagonist treatment disease, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Recommanded Product: 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 3, 2003, Hewawasam, Piyasena; Fan, Wenhong; Ding, Min; Flint, Kim; Cook, Deborah; Goggins, Gregory D.; Myers, Robert A.; Gribkoff, Valentin K.; Boissard, Christopher G.; Dworetzky, Steven I.; Starrett, John E. Jr.; Lodge, Nicholas J. published an article.Safety of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was 4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction. And the article contained the following:

Novel 4-aryl-3-(hydroxyalkyl)quinoline-2-ones I [R1 = HO, MeO; R2 = HO(CH2)n, n = 1 – 3; R2 = (E)-HOCH2CH:CH] were prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiol. methods. The effect of these maxi-K openers on corporal smooth muscle was studied in vitro using isolated rabbit corpus cavernosum. A potent maxi-K opener was identified as an effective relaxant of rabbit corporal smooth muscle and shown to be active in an in vivo animal model of male erectile function. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Safety of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to quinolinone hydroxyalkyl preparation corporal smooth muscle relaxant erectile disfunction, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Safety of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 10, 2006, Leroux, Frederic; Lefebvre, Olivier; Schlosser, Manfred published an article.Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was The “off-shore” construction of optionally substituted 4-trifluoromethyl-2-quinolinones. And the article contained the following:

Treatment of ortho-lithiated tert-Bu N-arylcarbamates (i.e., BOC-protected anilines) with N-(trifluoroacetyl)piperidine provides 2-(N-BOC-amino)aryl trifluoromethyl ketones which, upon reaction with an α-alkoxycarbonyl-substituted phosphorus ylide and acid (or base) yields 4-trifluoromethyl-2-quinolinones which may bear addnl. substituents at any available position. The method is convenient and expedient. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to quinoline trifluoromethyl preparation trifluoroacetylphenyl carbamate phosphorus ylide, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 9, 2008, Kaila, Neelu; Janz, Kristin Marie; Huang, Adrian; Moretto, Allessandro Fabio; Bedard, Patricia Ward published a patent.COA of Formula: C12H14F3NO2 The title of the patent was Preparation of quinoline compounds as selectin inhibitors for disease treatment. And the patent contained the following:

The present teachings relate to novel compounds of formula I wherein R1 is -OR9, -C(O)R10, etc.; R2 is -C(O)OR9, etc.; R3 and R3′ independently are H, -CN, -NO2, halo, etc.; R4-R7 independently are H, C1-10alkyl, etc.; or R3 and R3′ together, R4 and R5 together, and R6 and R7 together form part of a ring; R8 is (un)substituted C6-14 aryl or 5-14 membered heteroaryl; R9 is H, -C(O)R10, etc.; R10 is H, OH, SH, etc. Compounds of the present teachings can act as antagonists of the mammalian adhesion proteins known as selectins. Methods for treating or preventing selectin-mediated disorders are provided, which include administration of these compounds in a therapeutically effective amount Synthetic procedures for preparing I are exemplified. Example compound II, prepared by reacting the appropriate indoline-2,3-dione with the appropriate 2-oxopropyl acetate, caused 37% inhibition in a Biacore P-selectin/PSGL-1 inhibition assay at 250μM. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).COA of Formula: C12H14F3NO2

The Article related to quinoline compound preparation selectin inhibitor disease treatment, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.COA of Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics