Category: 141940-37-6

On August 26, 2010, Huang, Adrian; Moretto, Alessandro; Janz, Kristin; Lowe, Michael; Bedard, Patricia W.; Tam, Steve; Di, Li; Clerin, Valerie; Sushkova, Natalia; Tchernychev, Boris; Tsao, Desiree H. H.; Keith, James C. Jr.; Shaw, Gray D.; Schaub, Robert G.; Wang, Qin; Kaila, Neelu published an article.Application of 141940-37-6 The title of the article was Discovery of 2-[1-(4-Chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic Acid (PSI-421), a P-Selectin Inhibitor with Improved Pharmacokinetic Properties and Oral Efficacy in Models of Vascular Injury. And the article contained the following:

Previously, we reported the discovery of PSI-697 (1a), a C-2 benzyl substituted quinoline salicylic acid-based P-selectin inhibitor. It is active in a variety of animal models of cardiovascular disease. Compound 1a has also been shown to be well tolerated and safe in healthy volunteers at doses of up to 1200 mg in a phase 1 single ascending dose study. However, its oral bioavailability was low. Our goal was to identify a back up compound with equal potency, increased solubility, and increased exposure. We expanded our structure-activity studies in this series by branching at the α position of the C-2 benzyl side chain and through modification of substituents on the carboxylic A-ring of the quinoline. This resulted in discovery of PSI-421 with marked improvement in aqueous solubility and pharmacokinetic properties. This compound has shown oral efficacy in animal models of arterial and venous injury and was selected as a preclin. development compound for potential treatment of such diseases as atherosclerosis and deep vein thrombosis. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Application of 141940-37-6

The Article related to quinoline preparation p selectin inhibitor sar, Pharmacology: Structure-Activity and other aspects.Application of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 27, 2017, Frings, Marcus; Bolm, Carsten; Blum, Andreas; Gnamm, Christian published an article.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was Sulfoximines from a Medicinal Chemist’s Perspective: Physicochemical and in vitro Parameters Relevant for Drug Discovery. And the article contained the following:

Sulfoximines, sulfondiimides and sulfonimidamides are fascinating but not yet fully explored variants of the common sulfone or sulfonamide motif. In this study, we report the physicochem. and in vitro properties of sulfoximines and compare them with related analogs and isosteres. Furthermore, we present a matched mol. pair anal. of compounds from drug discovery projects within Boehringer Ingelheim. We demonstrate that the sulfoximine moiety is a chem. stable, comparatively polar and weakly basic functional group, often leading to favorable aqueous solubility, permeability and metabolic stability. Moreover, their addnl. vectors at nitrogen enable simple chem. modifications and thus facilitate exploration and fine-tuning of the mol. properties. We conclude that sulfoximines and their congeners do not exhibit any intrinsic flaw but significantly enrich the toolbox of medicinal chemists. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to sulfoximine preparation physicochem property drug discovery, metabolic stability, permeability, solubility, sulfondiimides, sulfonimidamides, sulfoximines, synthesis, Pharmacology: Structure-Activity and other aspects.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 15, 2019, Zeng, Xiaoming; Luo, Meiming; Zhang, Xue; Ling, Liang published a patent.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Method for synthesizing cis-trifluoromethyl cyclohexane derivative and heterocyclic compound by hydrogenation. And the patent contained the following:

The title method comprises adding trifluoromethyl arene or trifluoromethyl heterocyclic compound, cyclic (alkyl) (amino) carbene ruthenium complex catalyst and 4Å mol. sieve in organic solvent (n-hexane or 1,2-dichloroethane), introducing hydrogen gas, reacting under stirring at 40-60°C for 24 h, filtering, washing with dichloromethane, purifying by silica gel column chromatog. to obtain cis-trifluoromethyl cyclohexane derivative or cis-trifluoromethyl heterocyclic compound The invention has simple process, easily available raw material, mild reaction condition, wild application range and high selectivity. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to trifluoromethyl cis cycloalkane saturated heterocycle diastereoselective preparation, heteroarene arene cycloalkyl amino carbene rhodium catalyst dearomative reduction, Alicyclic Compounds: Cyclohexanes and other aspects.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 12, 2005, Chen, Li; Wang, Qingmin; Huang, Runqiu; Mao, Chunhui; Shang, Jian; Bi, Fuchun published an article.Product Details of 141940-37-6 The title of the article was Synthesis and insecticidal evaluation of propesticides of benzoylphenylureas. And the article contained the following:

Two series of benzoylphenylurea derivatives were synthesized as candidate propesticides by a nucleophilic addition reaction between 2,6-difluronbenzoyl isocyanate and N-substituted anilines. The new compounds were identified by 1H NMR spectroscopy, electron ionization-mass spectrometry, and elemental analyses. The bioactivities of the new compounds were evaluated. All of the propesticides were soluble in most organic solvents, and their hydrophobicities were improved. The result of the bioactivities of the new compounds against Oriental armyworm showed that some of the new compounds are active as compared to diflubenzuron and penfluron. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Product Details of 141940-37-6

The Article related to benzoylphenylurea derivative preparation insecticide, Agrochemical Bioregulators: Invertebrate and other aspects.Product Details of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hutchinson, Douglas K. published an article in 2016, the title of the article was Lanthanum(III) chloride, complex with lithium chloride, solution in tetrahydrofuran.Category: esters-buliding-blocks And the article contains the following content:

A review. Preparation, properties, availability, handling and applications of Lanthanum(III) chloride, complex with lithium chloride useful as an additive to reduce side reactions in the addition of lithium or Grignard reagents to carbonyl compounds were reviewed. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Category: esters-buliding-blocks

The Article related to review lanthanum lithium chloride complex preparation property safety application, Inorganic Chemicals and Reactions: Reviews and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 5, 2021, Romero, Eugenie; Oueslati, Saoussen; Benchekroun, Mohamed; D′Hollander, Agathe C. A.; Ventre, Sandrine; Vijayakumar, Kamsana; Minard, Corinne; Exilie, Cynthia; Tlili, Linda; Retailleau, Pascal; Zavala, Agustin; Elisee, Eddy; Selwa, Edithe; Nguyen, Laetitia A.; Pruvost, Alain; Naas, Thierry; Iorga, Bogdan I.; Dodd, Robert H.; Cariou, Kevin published an article.Related Products of 141940-37-6 The title of the article was Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of β-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D). And the article contained the following:

The occurrence of resistances in Gram neg. bacteria is steadily increasing to reach extremely worrying levels and one of the main causes of resistance is the massive spread of very efficient β-lactamases which render most β-lactam antibiotics useless. Herein, we report the development of a series of imino-analogs of β-lactams (namely azetidinimines) as efficient non-covalent inhibitors of β-lactamases. Despite the structural and mechanistic differences between serine-β-lactamases KPC-2 and OXA-48 and metallo-β-lactamase NDM-1, all three enzymes can be inhibited at a submicromolar level by compound 7dfm (I), which can also repotentiate imipenem against a resistant strain of Escherichia coli expressing NDM-1. We show that 7dfm can efficiently inhibit not only the three main clin.-relevant carbapenemases of Ambler classes A (KPC-2), B (NDM-1) and D (OXA-48) with Ki′s below 0.3 μM, but also the cephalosporinase CMY-2 (class C, 86% inhibition at 10 μM). Our results pave the way for the development of a new structurally original family of non-covalent broad-spectrum inhibitors of β-lactamases. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Related Products of 141940-37-6

The Article related to azetidinimine noncovalent beta lactamase inhibitor, azetidinimines, bacterial resistance, carbapenemase inhibitors, kpc-2, ndm-1, oxa-48, ynamides, Placeholder for records without volume info and other aspects.Related Products of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 1, 2015, Zhang, Xiaomin; Wang, Jian; Wan, Zehong published an article.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was New Reagent for Highly Efficient Synthesis of Trifluoromethyl-Substituted Arenes and Heteroarenes. And the article contained the following:

A new reagent trimethylsilyl chlorodifluoroacetate (TCDA) is reported for the introduction of a -CF3 group to arenes and heteroarenes. Compared with current known reagents, TCDA shows very broad scope with respect to electron-deficient, -neutral, and -rich aryl/heteroaryl iodides as well as excellent functional group tolerance, including ester, amide, aldehyde, hydroxyl, and carboxylic acid. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to trifluoromethylation aryl heteroaryl iodide trimethylsilyl chlorodifluoroacetate, General Organic Chemistry: Synthetic Methods and other aspects.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Medisetti, Venkataramana; Parimi, Umadevi; Anagani, Ramesh Babu; Satyanarayana, K. V. V. V. published an article in 2014, the title of the article was Nano-γ-Fe2O3: efficient, reusable and green catalyst for N-tert-butoxycarbonylation of amines in water.Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate And the article contains the following content:

An efficient and versatile practical protocol for the chemoselective N-tert-butoxycarbonylation of amines using Nano-γ-Fe2O3 and (BOC)2O is described. Nano-γ-Fe2O3 was applied as an efficient, green, heterogeneous and reusable catalyst at ambient temperature The method is general for the preparation of N-Boc derivatives I (R = PhNH, 4-ClC6H4NH, piperidino, etc.) of aliphatic, heterocyclic, aromatic as well as amino acid derivatives The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to carbamate chemoselective preparation green chem, amine dicarbonate protection carbonylation iron oxide, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 19, 2009, Castro Palomino Laria, Julio Cesar; Terricabras Belart, Emma; Erra Sola, Montserrat; Navarro Romero, Eloisa; Fonquerna Pou, Silvia; Cardus Figueras, Aranzazu; Lozoya Toribio, Maria Estrella published a patent.Recommanded Product: 141940-37-6 The title of the patent was Preparation of azabiphenylaminobenzoic acid derivatives as DHODH inhibitors. And the patent contained the following:

The title compounds I [R1 = H, halo, alkyl, etc.; R2 = H, halo, alkyl; R3 = CO2R5, CONHR5, tetrazolyl, SO2NHR5, CONHSO2R5 (wherein R5 = H, alkyl); R4 = H, alkyl; R9 = H, Ph; G1 = N, CR6 (R6 = H, halo, alkyl, etc.); G2 = H, OH, halo, cycloalkyl, etc.], useful as inhibitors of the dihydroorotate dehydrogenase (DHODH), were prepared and formulated. Thus, heating 2-amino-5-cyclopropylbenzoic acid with 5-bromo-2-phenylpyrimidine (preparations given) in the presence of Cu2O, Cu and K2CO3 in DME at 130°C afforded 57% II which showed IC50 of 105 nM against hDHODH. Pharmaceutical compositions comprising I, alone or in combination with other therapeutic agent, were disclosed. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: 141940-37-6

The Article related to azabiphenylaminobenzoic acid preparation dihydroorotate dehydrogenase dhodh inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 1, 2008, Stiff, Cory; Graber, David R.; Thorarensen, Atli; Wakefield, Brian D.; Marotti, Keith R.; Melchior, Earline P.; Sweeney, Michael T.; Han, Fusen; Rohrer, Douglas C.; Zurenko, Gary E.; Romero, Donna L. published an article.Synthetic Route of 141940-37-6 The title of the article was Bacterial translation inhibitors, 1-acylindazol-3-ols as anthranilic acid mimics. And the article contained the following:

The discovery and initial optimization of a novel anthranilic acid derived class of antibacterial agents has been described in a recent series of papers. This paper describes the discovery of 1-acylindazol-3-ols as a novel bioisostere of an anthranilic acid. The synthesis and structure-activity relationships of the indazol bioisosteres are described herein. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Synthetic Route of 141940-37-6

The Article related to acylindazolol preparation bacterial translation inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Synthetic Route of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics