These common heterocyclic compound, 141772-31-8, name is Methyl 5-amino-2-chloro-4-fluorobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H7ClFNO2
2. Preparation of Compound No. 18 A solution of 2-fluoro-4-chloro-5-methoxycarbonylaniline (1.0 g, 5 mmol) in THF (10 mL) was added dropwist to a solution of diphosgene (2.0 g, 10 mmol) in toluene (20 mL) with stirring at room temperature. The reaction mixture was stirred at room temperature for one hour and then heated to reflux for 4 hours. The mixture was then cooled to room temperature and the solvents were evaporated under reduced pressure to give 1.1 g of 2-fluoro-4-chloro-5-methoxycarbonylphenyl isocyanate as a solid.
The synthetic route of Methyl 5-amino-2-chloro-4-fluorobenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dow AgroSciences LLC; US6444615; (2002); B1;,
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