Electric Literature of 1415920-00-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1415920-00-1 name is Ethyl 4-amino-3,5-difluorobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of ethyl 4-amino-3,5-difluorobenzoate (i-27b) (1 g, 4.98 mmol), t-BuONO (3769 mg, 7.46 mmol) in20 mL CH3CN at room temperature was added CuBr2 (1.66 g, 7.46 mmol). The mixture wasstirred at room temperature for 1 hour, diluted with water (40 mL), and extracted with EtOAc(40 mL*2). The combined organic layers were washed with brine, dried over Na2SO4,filtered and concentrated. The residue was purified by column chromatography on silica gel(PE/EA = 100/1 to 20/1) to afford the title compound (0.9 g, 68 % yield). LCMS (ESI) calc?dfor C9H7BrF2O2 [M+H]: 265, found: 265.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 4-amino-3,5-difluorobenzoate, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BARR, Kenneth, Jay; BEINSTOCK, Corey; MACLEAN, John; ZHANG, Hongjun; BERESIS, Richard, Thomas; ZHANG, Dongshan; WO2014/28589; (2014); A2;,
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