Category: 14064-10-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14064-10-9, name is Diethyl 2-chloromalonate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 14064-10-9

To a stirring solution of M-2 (0.30 g) in acetone (30 ml) at ambient temperature is added diethyl chloromalonate (0.149 g) and K2CO3 (0.194 g). The resulting mixture is stirred for 16 h and solvent removed in vacuo. The residue is suspended between EtOAc/ H2O (100 ml each), the layers shaken, the organic layer separated, dried over Na2SO4, and solvent removed in vacuo. The residue is suspended in hexane, sonicated and filtered, to afford 0.295 g title compound as a white solid. 1H NMR (DMSO) delta0.83, 1.15, 1.50, 2.68, 2.95, 4.21, 4.92, 5.61, 6.83, 7.26, 7.49, 7.91; IR (mull) 3286, 1747, 1696, 1674, 1643, 1538, 1510, 1334, 1296, 1290, 1260, 1225, 1186, 1028, 698, cm-1. MS (FAB) m/z 586 (MH+), 586, 569, 434, 384, 305, 265, 176, 92, 91, 86. Anal. Found: C, 61.09; H, 6.56; N, 7.03.

According to the analysis of related databases, 14064-10-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pharmacia & Upjohn Company; US6353023; (2002); B1;,
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Related Products of 14064-10-9, The chemical industry reduces the impact on the environment during synthesis 14064-10-9, name is Diethyl 2-chloromalonate, I believe this compound will play a more active role in future production and life.

MDPD was synthesized according to a procedure described by Shipp et al. Briefly, NaH (1.24 g, 0.0520 mol) was suspended in THF (10 mL) and cooled to 0° C. using an ice bath. A solution of diphenylamine (3.38 g, 0.0200 mol) in DMSO (18 mL) and THF (9 mL) was added and stirred for 1 h at 0° C. Carbon disulfide (2.84 mL, 0.0472 mol) was added and the solution stirred for a further 30 min at 0° C. The solution was then cooled using an ethylene glycol/CO2 bath prior to the addition of diethyl chloromalonate (3.23 mL, 0.0200 mol) and further stirring for 2 h at room temperature. Any remaining NaH was hydrolyzed with methanol and the product was extracted with diethyl ether. Volatiles were then removed and the product was purified using a silica column (ethyl acetate:hexane mix 10:90 to remove diphenylamine impurity, followed by 30:70 to elute product). The product was dried under vacuum to yield a yellow solid (yield 72percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diethyl 2-chloromalonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARROWHEAD MADISON INC.; Wakefield, Darren H.; Rossi, Nicholas A.; Sheik, Dan; US2013/121954; (2013); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14064-10-9, name is Diethyl 2-chloromalonate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H11ClO4

REFERENCE EXAMPLE 5a Ethyl 3-amino-4-cyclopropylfuran-2-carboxylate; To a solution of compound obtained in reference example 4a (5 g, 43.47 mmol) in DMF (108 ml_) was added diethyl chloromalonate (8.4 ml_, 52.17 mmol). The reaction mixture was stirred overnight at room temperature. After diluting with water (500 ml_), the reaction mixture was extracted with ethyl acetate. The combined organic extracts were dried over Na2SO4. After filtration, the filtrate was concentrated to dryness providing an orange syrup. The orange syrup was dissolved in ethanol (217 ml_) to which 1 ,5-diazabicyclo[4.3.0]non-5-ene (5.9 ml_, 47.8 mmol) was added, and the mixture was stirred at room temperature overnight. The solution was concentrated to dryness and the crude residue was purified by flash chromatography on silica gel using ethyl acetate and hexane mixtures of increasing polarity to afford 3 g of the title compound (yield: 65percent) as a light brown oil. LC-MS (Method 2): tR = 1.88 min; m/z 196 (MH+).

According to the analysis of related databases, 14064-10-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PALAU PHARMA, S. A.; WO2009/115496; (2009); A1;,
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Reference of 14064-10-9, These common heterocyclic compound, 14064-10-9, name is Diethyl 2-chloromalonate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-[4-amino-5-(ethoxycarbonyl)furan-3-yl]piperazine-1-carboxylate tert-Butyl 4-(1-cyano-2-oxoethyl)piperidine-1-carboxylate (2.35 g, crude product), diethyl chloromalonate (1.94 g, 10 mmol) and 1,8-diazabicyclo[5.4.0]undec-7-ene (4.56 g, 30 mmol) were dissolved in tetrahydrofuran (20 mL), followed by stirring at room temperature overnight. Water was added to the reaction liquid, followed by extraction with ethyl acetate, and the organic layer was dried over anhydrous sodium sulfate and concentrated under a reduced pressure. The obtained residue was purified by using silica gel column chromatography (hexane:ethyl acetate=6:1?2:1) to give tert-butyl 4-[4-amino-5-(ethoxycarbonyl) furan-3-yl]piperazine-1-carboxylate (1.30 g, 38percent, 2 steps) as a yellow solid. 1H-NMR (CDCl3) delta: 1.38 (3H, t, J=7.1 Hz), 1.47 (9H, s), 1.87-1.95 (2H, m), 2.38-2.49 (1H, m), 2.74-2.87 (2H, m), 4.10-4.28 (2H, m), 4.35 (2H, q, J=7.1 Hz), 4.50 (2H, brs), 7.06 (1H, s).

The synthetic route of 14064-10-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KOWA CO., LTD.; Morimoto, Toshiharu; Koshizawa, Tomoaki; Watanabe, Gen; Ohgiya, Tadaaki; Yamasaki, Nao; Inoue, Noriyuki; US2013/102621; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 14064-10-9, name is Diethyl 2-chloromalonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14064-10-9, Application In Synthesis of Diethyl 2-chloromalonate

3-Bromobenzenecarbothioamide (1.00 g, 4.62 mmol) and diethyl chloropropanedioate (1.0 mL, 6.0 mmol) were dissolved in dioxane (35 mL). The mixture was heated at 80¡ãC and stirred overnight, whereupon the solvent was removed under vacuum. Ethyl 2-(3-bromophenyl)-4-hydroxy-1 ,3-thiazole-5-carboxylate was obtained as a yellow solid (1.09 g, 72percent) by trituration in acetonitrile. An oven-dried Schlenk tube equipped with a magnetic stir bar was charged with 1.5 mL of an aqueous solution of K2CO3 (2M, 3.0 mmol), tetrakis(triphenylphosphine)palladium(0) (140 mg, 0.121 mmol) and toluene (3 mL). The tube was capped with a rubber septum and immersed in an oil bath at 80 ¡ãC for 30 min. Ethyl 2-(3′-bromophenyl)-4-hydroxy-1 ,3- thiazole-5-carboxylate (188 mg, 0.575 mmol) and 2-trifluoromethyl-phenylboronic acid (218 mg, 1.15 mmol) were then added, and the reaction mixture stirred at 80¡ãC. Upon complete consumption of the starting material (12 h), as judged by thin-layer chromatography analysis, the reaction mixture was filtered on a celite pad. The filtrate was diluted with ethyl acetate, and extracted with water. The organic layers were further washed with brine and dried over sodium sulfate. The product was isolated by column chromatography (hexanes/EtOAc) as a yellow solid (56 mg, 25percent). 1H-NMR (DMSO-cie) delta (ppm): 10.82 (br s, 1 H), 7.96 (d, 2H, J=8.11), 7.86 (d, 2H, J=7.57), 7.78-7.73 (m, 1 H), 7.67-7.62 (m, 1 H), 7.47-7.41 (m, 2H), 4.16 (q, 2H, J=7.03), 1.24 (t, 3H, J=7.03).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; DOMPE’ S.P.A.; MORICONI, Alessio; BIANCHINI, Gianluca; COLAGIOIA, Sandro; BRANDOLINI, Laura; ARAMINI, Andrea; LIBERATI, Chiara; BOVOLENTA, Silvia; WO2013/92711; (2013); A1;,
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Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14064-10-9, name is Diethyl 2-chloromalonate, A new synthetic method of this compound is introduced below., Computed Properties of C7H11ClO4

DBU (4.64 g, 30.5 mmol) was added at room temperature to a solution of 8 (7.00 g, 27.7 mmol) and diethyl chloromalonate (6.47 g, 33.2 mmol) in DMF (70 ml). After stirring at this temperature for 24 h, the reaction mixture was quenched with H2O (200 ml) at 0 ¡ãC. The aqueous layer was extracted with AcOEt (200 ml ¡Á 2). The combined organic layers were dried over Na2SO4, filtered, and concentrated in vacuo. The residue was purified by column chromatography on silica gel (hexane-AcOEt) to give 9 (4.67 g, 50percent) as a yellow solid. 1H NMR (400 MHz, CDCl3) delta 1.38 (3H, t, J = 7.1 Hz), 1.47 (9H, s), 1.87-1.95 (2H, m), 2.38-2.49 (1H, m), 2.74-2.87 (2H, m), 4.10-4.28 (2H, m), 4.35 (2H, q, J = 7.1 Hz), 4.50 (2H, br s), 7.06 (1H, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Koshizawa, Tomoaki; Morimoto, Toshiharu; Watanabe, Gen; Watanabe, Toshiaki; Yamasaki, Nao; Sawada, Yoshikazu; Fukuda, Tomoaki; Okuda, Ayumu; Shibuya, Kimiyuki; Ohgiya, Tadaaki; Bioorganic and Medicinal Chemistry Letters; vol. 27; 15; (2017); p. 3249 – 3253;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14064-10-9, name is Diethyl 2-chloromalonate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 14064-10-9

A solution of the product of Example 107a (1.2 g, 4.4 mmol) and triethylamine (0.49 g, 4.8 mmol) in dichloromethane (25 ML) was treated dropwise with ethyl chloromalonate (0.73 g, 4.8 mmol), stirred for 2 hr and partitioned between ethyl acetate and water and the layers were separated.The ethyl acetate layer was washed with brine, dried (Na2SO4), and concentrated.The residue was purified by column chromatography on silica gel eluding with hexane and ethyl acetate (3:1) to provide the title compound (1.1 g, 65percent). MS (DCI) m/z 387 (M+H)+.

According to the analysis of related databases, 14064-10-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pratt, John K.; Betebenner, David A.; Donner, Pemela L.; Green, Brian E.; Kempf, Dale J.; McDaniel, Keith F.; Maring, Clarence J.; Stoll, Vincent S.; Zhang, Rong; US2004/87577; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics