Category: 13669-10-8

In situ generation of nitrile oxides from copper carbene and tert-butyl nitrite: synthesis of fully substituted isoxazoles was written by Chen, Rongxiang;Ogunlana, Abosede Adejoke;Fang, Shangwen;Long, Wenhao;Sun, Hongmei;Bao, Xiaoguang;Wan, Xiaobing. And the article was included in Organic & Biomolecular Chemistry in 2018.Synthetic Route of C9H10O3S This article mentions the following:

A [3 + 2] cycloaddition reaction of β-keto esters with nitrile oxides, which were generated in situ from copper carbene and tert-Bu nitrite, is reported. This three-component reaction provides methodol. for the direct synthesis of fully substituted isoxazole derivatives, featuring mild reaction conditions, readily accessible starting materials and simple operation. The exptl. studies and DFT calculations suggest that the reaction starts with the generation of the key intermediate nitrile oxides, followed by a [3 + 2] cycloaddition reaction of β-keto esters to give the final isoxazole products. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Synthetic Route of C9H10O3S).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C9H10O3S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Direct Fluoro-aminosulfenylation of Active Methylenes by Dialkylaminosulfur Trifluorides under Catalyst-Free Conditions was written by Saidalimu, Ibrayim;Guo, Ming;Tokunaga, Etsuko;Shibata, Norio. And the article was included in Asian Journal of Organic Chemistry in 2016.Recommanded Product: 13669-10-8 This article mentions the following:

The direct fluoro-aminosulfenylation of active methylene compounds, e.g., 2-(2,3-dihydro-1H-inden-1-ylidene)malononitrile by diethylaminosulfur trifluoride and its derivatives F₃SR (R = dimethylamino, diethylamino, bis(2-methoxyethyl)amino, morpholino) has been disclosed. A variety of α-fluorinated α-sulfenamides with a tetrasubstituted carbon center, e.g., I were synthesized from active methylene compounds under mild reaction conditions. This direct fluoro-aminosulfenylation reaction occurs very smoothly under metal-free and base-free conditions. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 13669-10-8

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Diastereoselective Synthesis of Rauhut-Currier-Type Adducts via an Unexpected α-Addition of α,β-Unsaturated γ-Butyrolactams to Coumarin Derivatives was written by Yang, Shu-Mei;Madhusudhan Reddy, Ganapuram;Liu, Meng-Hsien;Wang, Tzu-Ping;Yu, Jhen-Kuei;Lin, Wenwei. And the article was included in Journal of Organic Chemistry in 2017.Application In Synthesis of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:

A novel, base-catalyzed and highly diastereoselective direct Michael addition-isomerization sequence is presented for the efficient synthesis of Rauhut-Currier-type adducts. An unexpected α-addition of γ-butyrolactam onto the 3-acyl coumarin derivatives was observed rather than the γ-addition, which is more common. The adducts could further undergo hydrolysis/decarboxylation to generate the products which are equivalent to those obtained by α-addition of γ-butyrolactam onto the corresponding chalcones. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Application In Synthesis of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rhodium(I)-Catalyzed Coupling-Cyclization of C=O Bonds with α-Diazoketones was written by Chen, Ziyang;Hu, Xinwei;Huang, Junmin;Zeng, Wei. And the article was included in Organic Letters in 2018.COA of Formula: C9H10O3S This article mentions the following:

An unprecedented intermol. nucleophilic attack of C=X bonds (X = O and S) on the rhodium(I)-carbenes has been developed. This transformation allows for the coupling-cyclization of aroylamides with α-diazoketones and provides concise access to 2,4,5-trisubstituted 1,3-oxazoles, e.g., I, and 1,3-thiazoles, e.g., II, with a broad tolerance of functional groups. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8COA of Formula: C9H10O3S).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C9H10O3S

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Facile synthesis of δ-ketoesters via formal two-carbon insertion into β-ketoesters was written by Jiang, Yan;Xi, Song;Wang, Qi;Fu, Lin;He, Ling;Wang, Zhen;Zhang, Min. And the article was included in Tetrahedron Letters in 2022.Category: esters-buliding-blocks This article mentions the following:

A formal two-carbon insertion into β-ketoesters with vinylmetal has been developed for the rapid synthesis of δ-ketoesters. This method features high efficiency, simple operation, and mild conditions without the usage of bases and catalysts. The reaction is postulated to proceed via a tandem process in volving nucleophilic addition of vinylmetal to ketone, retro-aldol reaction to give an enolate anion and an enone, and finally Michael addition of these two intermediates. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Category: esters-buliding-blocks).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Transition-Metal-Free Approach to Polysubstituted Furans was written by You, Changming;Zhang, Zhenming;Tu, Yongliang;Tang, Hong;Wang, Yuanfeng;Long, Da;Zhao, Junfeng. And the article was included in Journal of Organic Chemistry in 2020.Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:

A convenient and straightforward strategy for the synthesis of 2,3-disubstituted and 2,3,5-trisubstituted furans via a base-promoted domino reaction of β-keto compounds with vinyl dichlorides is described. This transition-metal-free approach proceeds under operationally simple reaction conditions featuring easily available starting materials, a broad substrate scope, and good functional group tolerance. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Metal-Free Synthesis of 2-Substituted Quinolines via High Chemoselective Domino Condensation/Aza-Prins Cyclization/Retro-Aldol between 2-Alkenylanilines with β-Ketoesters was written by Nan, Jiang;Chen, Pu;Zhang, Yuxin;Yin, Yun;Wang, Bo;Ma, Yangmin. And the article was included in Journal of Organic Chemistry in 2020.Formula: C9H10O3S This article mentions the following:

A highly chemoselective domino condensation/aza-Prins cyclization/retro-aldol between 2-alkenylanilines with β-dicarbonyl compounds under metal-free conditions was accomplished, giving a large category of valuable 2-substituted quinolines in good yields with excellent functional group toleration. This newly established process, adopting β-ketoesters as masked C1 synthons via C-C cleavage, could even be simplified into a three-component [3 + 2 + 1] domino version consisting of exceedingly low-priced com. starting materials. The synthetic application of products was exemplified by several intriguing chem. operations. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Formula: C9H10O3S).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C9H10O3S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Copper(II) triflate catalyzed amination of 1,3-dicarbonyl compounds was written by Ton, Thi My Uyen;Himawan, Fanny;Chang, Joyce Wei Wei;Chan, Philip Wai Hong. And the article was included in Chemistry – A European Journal in 2012.Application of 13669-10-8 This article mentions the following:

Preparation of α,α-acyl amino acid derivatives was carried out efficiently by Cu(OTf)₂+1,10-phenanthroline (1,10-phen)-catalyzed amination of 1,3-dicarbonyl compounds with PhI=NSO₂Ar. The mechanism is thought to initially involve aziridination of the enolic form of the substrate, formed in situ through coordination to the Lewis acidic metal catalyst, by the putative copper-nitrene/imido species generated from the reaction of the metal catalyst with the iminoiodane source. Subsequent ring opening of the resultant aziridinol adduct under the Lewis acidic conditions then provided the α-aminated product. The utility of this method was exemplified by the enantioselective synthesis of a precursor of 3-styryl-2-benzoyl-L-alanine. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Application of 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Regioselective Syntheses of 1,2-Benzothiazine 1-Imines by Rhodium-Catalyzed Annulation Reactions of Sulfondiimines was written by Bohmann, Rebekka Anna;Schoebel, Jan-Hendrik;Unoh, Yuto;Miura, Masahiro;Bolm, Carsten. And the article was included in Advanced Synthesis & Catalysis in 2019.Computed Properties of C9H10O3S This article mentions the following:

Unprecedented 1,2-benzothiazine 1-imines I (R¹ = H, OMe, Me; R² = Me, cyclopropyl; R³ = H, Me, Ph; R⁴ = Me, thiophen-2-yl, Ph, etc.; R⁵ = H, C(O)OC₂H₅) have been prepared from sulfondiimines 4-R¹C₆H₄S(R²)(=NH)=NR³ by regioselective rhodium-catalyzed annulation reactions with diazo keto esters R⁴C(O)C(=N₂)R⁵ and α-substituted (pseudo)halo acetophenones R⁶CH₂C(O)C₆H₅ (R⁶ = Cl, tosyloxy, mesyloxy) as coupling partners. A representative product was characterized by single crystal X-ray structure anal., and the applicability of the resulting three-dimensional heterocycles I (R¹ = H, R² = Me, R³ = Ph, R⁴ = 4-bromophenyl, R⁵ = H) to Buchwald-Hartwig-type amination reactions is shown. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Computed Properties of C9H10O3S).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C9H10O3S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Copper-Mediated Aerobic Synthesis of 3-Azabicyclo[3.1.0]hex-2-enes and 4-Carbonylpyrroles from N-Allyl/Propargyl Enamine Carboxylates was written by Toh, Kah Kah;Wang, Yi-Feng;Ng, Eileen Pei Jian;Chiba, Shunsuke. And the article was included in Journal of the American Chemical Society in 2011.Computed Properties of C9H10O3S This article mentions the following:

Synthetic methods for 3-azabicyclo[3.1.0]hex-2-enes, e.g. I, and 4-carbonylpyrroles, e.g. II, have been developed that use copper-mediated/catalyzed reactions of N-allyl/propargyl enamine carboxylates under an O₂ atmosphere and involve intramol. cyclopropanation and carbooxygenation, resp. These methodologies take advantage of orthogonal modes of chem. reactivity of readily available N-allyl/propargyl enamine carboxylates; the complementary pathways can be accessed by slight modification of the reaction conditions. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Computed Properties of C9H10O3S).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C9H10O3S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics