Category: 13669-10-8

One-Pot Tandem Michael Addition/Enantioselective Conia-Ene Cyclization Mediated by Chiral Iron(III)/Silver(I) Cooperative Catalysis was written by Horibe, Takahiro;Sakakibara, Masato;Hiramatsu, Rin;Takeda, Kazuki;Ishihara, Kazuaki. And the article was included in Angewandte Chemie, International Edition in 2020.Reference of 13669-10-8 This article mentions the following:

The first one-pot tandem Michael addition/enantioselective Conia-ene cyclization of N-protected prop-2-yn-1-amines with 2-methylene-3-oxoalkanoates promoted by chiral iron(III)/silver(I) cooperative catalysts was developed. Alkyl 4-methylenepyrrolidine-3-acyl-3-carboxylates, which can be transformed into 灏?proline derivatives, were obtained in high yield with high enantioselectivity. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Reference of 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lewis Acid-Catalyzed Synthesis of Benzofurans and 4,5,6,7-Tetrahydrobenzofurans from Acrolein Dimer and 1,3-Dicarbonyl Compounds was written by Huang, Wenbo;Xu, Jing;Liu, Changhui;Chen, Zhiyan;Gu, Yanlong. And the article was included in Journal of Organic Chemistry in 2019.Recommanded Product: 13669-10-8 This article mentions the following:

2,3-Disubstituted benzofurans such as benzofurandicarboxylate I were prepared by cyclocondensation of acrolein dimer (2H-3,4-dihydro-2-pyrancarboxaldehyde) and 1,3-dicarbonyl compounds, particularly 灏?ketoesters and 1,3-diketones, in the presence of Lewis acid catalysts [either AlCl₃ or Sc(OTf)₃ or in one case, BF₃璺疎t₂O] using N-bromosuccinimide (NBS) as an oxidant. The method was used to prepare benzbromarone and amiodarone. An oxobutylfurancarboxylate intermediate in the cyclocondensation of acrolein dimer and Me acetoacetate was isolated; cyclocondensation with indoles, 1,2,4-trimethoxybenzene, and 1,1-diphenylethylene yielded aryl- and diphenylvinyl-substituted tetrahydrobenzofurancarboxylates such as II [R = 3-indolyl, 1-methyl-3-indolyl, 2,4,5-(MeO)₃C₆H₂, Ph₂C:CH]. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Modular Synthesis of Bicyclic and Tricyclic (Aza-) Arenes from Nucleophilic (Aza-)Arenes with Electrophilic Side Arms via [4+2] Annulation Reactions was written by Huang, Wenbo;Chen, Shaomin;Yang, Jian;El-Harairy, Ahmed;Wang, Xin;Li, Minghao;Gu, Yanlong. And the article was included in Advanced Synthesis & Catalysis in 2019.Application of 13669-10-8 This article mentions the following:

An efficient strategy for the synthesis of bicyclic aza-arenes I [R¹ = Me, Ph, 2-thienyl, etc.; R² = Me, OEt, OBn, etc.; Ar = OMe, Cl, Ph, etc.] and tricyclic aza-arenes, e.g., II from a nucleophilic aza-arene with an electrophilic side arm was developed. The aza-arene precursor had both nucleophilic and electrophilic sites, which were fixed at a 1,4-distance. The bicyclic and tricyclic (aza-)arene products I and II were constructed via [4+2] annulation by using scandium(III) triflate as a catalyst and enolizable ketones or aldehydes as the counterpart reagents. A variety of six-membered carbocycles and heterocycles, such as indolizines, indoles, naphthalenes, carbazoles and pyrido[1,2-浼猐indoles, were successfully synthesized. Some one-pot sequential reactions were also developed, in which the 1,4-donor-acceptor precursors can be synthesized via oxidation of alcs. or a proper condensation reaction. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Application of 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electrochemical Oxidative Cyclization: Synthesis of Polysubstituted Pyrrole from Enamines was written by Chen, Zhiwei;Shi, Guang;Tang, Wei;Sun, Jie;Wang, Wenxing. And the article was included in European Journal of Organic Chemistry in 2021.Category: esters-buliding-blocks This article mentions the following:

A conceptually novel method for the preparation of pyrrole is described by electrochem.-oxidation-induced intermol. annulation via enamines. In a simple undivided cell, based on a sodium acetate-facilitated, polysubstituted pyrrole derivations has been facilely synthesized under external oxidant-free condition. This electrosynthetic approach providing an environmentally benign protocol for C-C bond cross-coupling and oxidative annulation, which features unparalleled broad scope of substrates and practicality. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Category: esters-buliding-blocks).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electroreductive 4-pyridylation of unsaturated compounds using gaseous ammonia as a hydrogen source was written by Ding, Weijie;Sheng, Jie;Li, Jin;Cheng, Xu. And the article was included in Organic Chemistry Frontiers in 2022.Application of 13669-10-8 This article mentions the following:

Electrochem. radical-cross-coupling with ammonia as a terminal reductant was reported in the reactions of 浼?Keto esters, 灏?keto esters, 浼?灏?unsaturated esters, and 浼?灏?unsaturated ketones with 4-CN pyridine. More than 50 corresponding pyridylation products were synthesized under constant current conditions using thiourea as an essential promoter to activate the intermediate derived from 4-CN pyridine. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Application of 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application of 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Complementing Pyridine-2,6-bis(oxazoline) with Cyclometalated N-Heterocyclic Carbene for Asymmetric Ruthenium Catalysis was written by Li, Long;Han, Feng;Nie, Xin;Hong, Yubiao;Ivlev, Sergei;Meggers, Eric. And the article was included in Angewandte Chemie, International Edition in 2020.Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:

A strategy for expanding the utility of chiral pyridine-2,6-bis(oxazoline) (pybox) ligands for asym. transition metal catalysis is introduced by adding a bidentate ligand to modulate the electronic properties and asym. induction. Specifically, a ruthenium(II) pybox fragment is combined with a cyclometalated N-heterocyclic carbene (NHC) ligand to generate catalysts for enantioselective transition metal nitrenoid chem., including ring contraction to chiral 2H-azirines (up to 97% ee with 2000 TON) and enantioselective C(sp³)-H aminations (up to 97% ee with 50 TON). In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Copper-Mediated Oxidative Transformation of N-Allyl Enamine Carboxylates toward Synthesis of Azaheterocycles was written by Toh, Kah Kah;Biswas, Anup;Wang, Yi-Feng;Tan, Yun Yun;Chiba, Shunsuke. And the article was included in Journal of the American Chemical Society in 2014.Formula: C9H10O3S This article mentions the following:

A method for synthesis of 3-azabicyclo[3.1.0]hex-2-enes has been developed by intramol. cyclopropanation of readily available N-allyl enamine carboxylates. Two complementary reaction conditions, CuBr-mediated aerobic and CuBr₂-catalyzed-PhIO₂-mediated systems effectively induced stepwise cyclopropanation via carbocupration of alkenes. Oxidative cyclopropane ring-opening of 5-substituted 3-azabicyclo[3.1.0]hex-2-enes was also developed for synthesis of highly substituted pyridines. In addition, diastereoselective reduction of 3-azabicyclo[3.1.0]hex-2-enes to 3-azabicyclo[3.1.0]hexanes was achieved using NaBH₃CN in the presence of acetic acid. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Formula: C9H10O3S).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C9H10O3S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Silver-mediated annulation between 5-H-1,2,3-thiadiazoles and 1,3-dicarbonyl compounds to construct polysubstituted furans was written by Feng, Mengxia;Jiang, Huanfeng;Huang, Liangbin. And the article was included in Organic Chemistry Frontiers.Recommanded Product: 13669-10-8 This article mentions the following:

An efficient synthesis of polysubstituted furans I [R = Ph, furan-2-yl, 4-MeSC₆H₄, etc.; R¹ = Me, i-Pr, Ph, etc.; R² = CN, C(O)Me, C(O)OEt, etc.] by Ag(I)-mediated annulation between 5-H-1,2,3-thiadiazoles and 1,3-dicarbonyl compounds was reported. The methodol. was characterized by availability of starting materials, good functional group tolerance, and the successful construction of heterocycle-substituted furans. The utilization of this method was evidenced by the gram-scale synthesis and further elaboration of the product. In addition, preliminary control experiments ruled out the formation of an alkynyl silver intermediate. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Silver-mediated annulation between 5-H-1,2,3-thiadiazoles and 1,3-dicarbonyl compounds to construct polysubstituted furans was written by Feng, Mengxia;Jiang, Huanfeng;Huang, Liangbin. And the article was included in Organic Chemistry Frontiers.Recommanded Product: 13669-10-8 This article mentions the following:

An efficient synthesis of polysubstituted furans I [R = Ph, furan-2-yl, 4-MeSC₆H₄, etc.; R¹ = Me, i-Pr, Ph, etc.; R² = CN, C(O)Me, C(O)OEt, etc.] by Ag(I)-mediated annulation between 5-H-1,2,3-thiadiazoles and 1,3-dicarbonyl compounds was reported. The methodol. was characterized by availability of starting materials, good functional group tolerance, and the successful construction of heterocycle-substituted furans. The utilization of this method was evidenced by the gram-scale synthesis and further elaboration of the product. In addition, preliminary control experiments ruled out the formation of an alkynyl silver intermediate. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Divergent Synthesis of β-Hydroxy Amides (Esters) and γ-Amino Alcohols via Ir/f-Diaphos Catalyzed Asymmetric Hydrogenation was written by Zhao, Xianghua;Yang, Zehui;Cheng, Yuqi;Huang, An;Hu, Fangyuan;Ling, Fei;Zhong, Weihui. And the article was included in Advanced Synthesis & Catalysis in 2022.SDS of cas: 13669-10-8 This article mentions the following:

The iridium/f-diaphos L2 or L9 catalyzed asym. hydrogenation of β-aryl β-keto amides (esters), and β-amino ketones to afford two enantiomers of the desired chiral alcs. was realized with 90%-99% yield and 73%-99% ee. This protocol could be easily conducted on gram scale in the presence of low catalyst loading (up to 9900 TON). Moreover, the hydrogenated products are versatile building blocks for a variety of biol. active mols. and drugs, such as Fluoxetine, Dapoxetine and so on. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8SDS of cas: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics