Adding a certain compound to certain chemical reactions, such as: 135908-43-9, name is Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate hydrochloride, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 135908-43-9, COA of Formula: C10H18ClNO2
(l-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-mo holino-carbenium hexafluorophosphate (COMU, 1181 mg, 2.76 mmol) was added to a N,N-dimethylformamide (6 mL) solution of Hunig’s base (1.47 mL, 8.40 mmol), methyl 4-aminobicyclo[2.2.2] octane- 1- carboxylate hydrochloride (527 mg, 2.40 mmol, ArkPharm), and 2-(4-chloro-3- fluorophenoxy)acetic acid (515 mg, 2.52 mmol) that was kept stirring at 0 C. The ice bath was removed, and the reaction was left stirring at ambient temperature for 1 hour. The resulting solution was filtered through a glass microfiber frit and purified by preparative HPLC [YMC TriArt C18 Hybrid 5 mupiiota column, 50 x 100 mm, flow rate 70 mL/minute, 5-100% gradient of acetonitrile in buffer (0.1 % trifluoroacetic acid)] to give the title compound (0.78 g, 2.11 mmol, 88 % yield).JH NMR (400 MHz, DMSO-+) m/z 370 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen Ann; SIDRAUSKI, Carmela; FROST, Jennifer M.; TONG, Yunsong; XU, Xiangdong; SHI, Lei; XIONG, Zhaoming; (165 pag.)WO2019/90090; (2019); A1;,
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