13412-12-9 Archives - Esters-buliding-blocks

Chithanna, Sivanna’s team published research in Organic & Biomolecular Chemistry in 2021 | CAS: 13412-12-9

Methyl 3-(methylamino)but-2-enoate(cas: 13412-12-9) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Product Details of 13412-12-9

The author of 《Acid-catalyzed, regioselective [3+3] annulation of enaminones and α-substituted cinnamic acids: access to 3,4-dihydropyridones and 2-piperidinones》 were Chithanna, Sivanna; Roy, Animesh; Yang, Ding-Yah. And the article was published in Organic & Biomolecular Chemistry in 2021. Product Details of 13412-12-9 The author mentioned the following in the article:

An efficient strategy for the synthesis of structurally diverse 3,4-dihydropyridones, e.g., I and 2-piperidinones II (R = H, Me; R1 = H, OMe; R2 = H, Br) is reported. The former was prepared via acid-catalyzed Michael addition of enaminones, e.g., 3-(ethylamino)-5,5-dimethyl-2-cyclohexen-1-one to electron-deficient α-substituted cinnamic acids R3CH=C(R4)C(O)OH (R3 = Ph, 1-naphthyl, 2-furyl, etc.; R4 = CN, C(O)2Et) followed by lactamization, whereas the latter was synthesized by the same methodol. except that cinnamic acids were replaced with coumarin 3-carboxylic acids. A unique regioselective reactivity of the enaminones toward different cinnamic acid derivatives is described. In the experimental materials used by the author, we found Methyl 3-(methylamino)but-2-enoate(cas: 13412-12-9Product Details of 13412-12-9)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The important role of C6H11NO2

The synthetic route of Methyl 3-(methylamino)but-2-enoate has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 13412-12-9, name is Methyl 3-(methylamino)but-2-enoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: esters-buliding-blocks

To 3- methylamino-but-2-enoic acid methyl ester (5.Og, 39.1mmol) in THF (7OmL) was added pyridine (3.7mL). The mixture was cooled to O0C, and 4-bromobenzoyl chloride (8.55g, 39.1mmol) in THF (3OmL) was added dropwise over 2 minutes. The reaction was warmed to room temperature over 1 hour and then stirred at room temperature overnight. Aqueous work-up gave the title compound.

The synthetic route of Methyl 3-(methylamino)but-2-enoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMIRA PHARMACEUTICALS, INC.; HUTCHINSON, John Howard; SEIDERS, Thomas Jon; WANG, Bowei; ARRUDA, Jeannie M.; ROPPE, Jeffrey Roger; PARR, Timothy; WO2010/141761; (2010); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The important role of 13412-12-9

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13412-12-9, name is Methyl 3-(methylamino)but-2-enoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Methyl 3-(methylamino)but-2-enoate

Step 2: 2-(4-Bromo-benzoyl)-3-[(E)-methylimino] -butyric acid methyl ester; [00439] 4-Bromobenzoyl chloride (17.14g, 78.1mmol) and 3-methylamino-but-2-enoic acid methyl ester (10. Og, 78.1mmol) were combined in THF (60OmL) and cooled to O0C. Pyridine (6.8mL, 85.9mmol) was added by syringe, and the reaction was stirred overnight at room temperature. Solid pyridine hydrochloride was observed on the flask walls, so the solution was decanted and then concentrated to 10% of its original volume. The residue was diluted with EtOAc (40OmL) and washed twice with H2O. The organic layer was dried, filtered, and concentrated to give the title compound.

The synthetic route of 13412-12-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMIRA PHARMACEUTICALS, INC.; HUTCHINSON, John Howard; SEIDERS, Thomas Jon; ARRUDA, Jeannie M.; WO2010/68775; (2010); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Extracurricular laboratory: Synthetic route of 13412-12-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-(methylamino)but-2-enoate, its application will become more common.

Synthetic Route of 13412-12-9,Some common heterocyclic compound, 13412-12-9, name is Methyl 3-(methylamino)but-2-enoate, molecular formula is C6H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2: 2-(4-Bromo-benzoyl)-3-oxo-butyric acid methyl ester To 3-methylamino-but-2-enoic acid methyl ester (5.0 g, 39.1 mmol) in THF (100 mL) was added pyridine (3.7 mL, 47 mmol). The mixture was cooled to 0 C. and 4-bromobenzoyl chloride (8.55 g, 39.1 mmol) in THF (30 mL) was added dropwise over 2 minutes. The reaction was warmed to room temperature over 1 hour and stirred overnight. Aqueous workup provided the title compound.

Reference:
Patent; Amira Phamaceuticals, Inc.; US2011/82181; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The important role of 13412-12-9

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 13412-12-9, A common heterocyclic compound, 13412-12-9, name is Methyl 3-(methylamino)but-2-enoate, molecular formula is C6H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2: 2-(4-Bromo-benzoyl)-3-oxo-butyric acid methyl ester To 3-methylamino-but-2-enoic acid methyl ester (5.0 g, 39.1 mmol) in THF (100 mL) was added pyridine (3.7 mL, 47 mmol). The mixture was cooled to 0 C., and 4-bromobenzoyl chloride (8.55 g, 39.1 mmol) in THF (30 mL) was added dropwise over 2 minutes. The reaction was warmed to room temperature over 1 hour and stirred overnight. Aqueous workup provided the title compound.

Reference:
Patent; AMIRA PHARMACEUTICALS, INC.; US2012/258987; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Extracurricular laboratory: Synthetic route of 13412-12-9

The synthetic route of 13412-12-9 has been constantly updated, and we look forward to future research findings.

13412-12-9, name is Methyl 3-(methylamino)but-2-enoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of Methyl 3-(methylamino)but-2-enoate

General procedure: 1195 mg (9.25 mmol 1 eq.) 1 and 1000 mg (9.25 mmol 1 eq.) 1,4-benzoquinone is solved in 12 mL nitromethane. The mixture is left for 24 hrs (no stirring). Crystals of product precipitate. They were filtered, washed with nitromethane and recrystallized from EtOAc. Rf in PE+EtOAc 2+1: 0.2. Yellow solid, yield: 1300 mg, 64 %. Compound described in 2.

The synthetic route of 13412-12-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Schaefer, Anja; Burstein, Ethan S.; Olsson, Roger; Bioorganic and Medicinal Chemistry Letters; vol. 24; 8; (2014); p. 1944 – 1947;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The origin of a common compound about 13412-12-9

The synthetic route of Methyl 3-(methylamino)but-2-enoate has been constantly updated, and we look forward to future research findings.

Electric Literature of 13412-12-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13412-12-9, name is Methyl 3-(methylamino)but-2-enoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 2: 2-(4-Bromo-3-methyl-benzoyl)-3-[(E)-methylimino]-butyric acid methyl esterTo 4-bromo-3-methyl-benzoyl chloride (40.0 mmol) in tetrahydrofuran (300 mL) wad added 3-methylamino-but-2-enoic acid methyl ester (5.12 g, 40.0 mmol), followed by pyridine (3.2 mL, 40.0 mmol), and the reaction was stirred overnight at room temperature. Solid pyridine hydrochloride coated the flask, so the mixture was decanted, and the solid was washed three times with EtOAc. The combined solutions were concentrated and diluted with EtOAc (500 mL), and the mixture was washed three times with water. The aqueous layer was separated and back-extracted with EtOAc, and the combined organic layers were dried over MgSO4, filtered, and concentrated to give the title compound.

The synthetic route of Methyl 3-(methylamino)but-2-enoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMIRA PHARMACEUTICALS, INC.; US2010/152257; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics