Category: 134-20-3

Adding a certain compound to certain chemical reactions, such as: 134-20-3, name is Methyl 2-aminobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 134-20-3, HPLC of Formula: C8H9NO2

In a 100 L double-layer glass reactor, 26.50 kg of dichloromethane, 8.0 kg of purified water, and 3.02 kg of methyl 2-aminobenzoate were successively added, and the mixture was uniformly stirred.A solution of bromine (3.83 kg) in dichloromethane (5.3 kg) was slowly added to the reaction mixture obtained above at normal temperature.After the addition was completed, stirring was continued for 10 minutes, and 2.50 kg of a 30% hydrogen peroxide solution was slowly added to the reaction solution, and the mixture was stirred for 6 hours, and the reaction was completed.To the reaction solution, slowly add 3.5 kg of a 20% sodium sulfite solution to quench the reaction, phase separate, and extract the organic phase with 8.0 kg of purified water.The aqueous phase was extracted twice with dichloromethane, and the organic phases were combined.The residue was transferred to a 100 L autoclave and 15.0 kg of methanol was added, heated to dissolve, and stirred for 15 minutes.The reaction solution was transferred to a crystallizing tank, and slowly cooled to room temperature at rest, and then placed in a refrigerator and further cooled to 0 C for 2 hours.The solid was filtered and dried at 50 C. After the water was passed, the yield was 5.88 kg, and the yield was 96%.

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Reference:
Patent; Guangzhou Yipinhong Pharmaceutical Co., Ltd.; Guangdong Zerui Pharmaceutical Co., Ltd.; Li Hanxiong; Lan Xiaobing; Yan Xinxing; (20 pag.)CN109535010; (2019); A;,
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Application of 134-20-3, These common heterocyclic compound, 134-20-3, name is Methyl 2-aminobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a round bottom flask was added CuBr2 (33 mmol, 7.40 g), EtOH (250 mL) and 14a (66 mmol, 10.00 g). The mixture was stirred at 35C for 2 h. Then, another portion of CuBr2 (33 mmol, 7.40 g) was added, and the mixture was continuously stirred for 1 h at 35C before being heated at reflux. After the completion of the reaction, the mixture was cooled to room temperature, and the solvent was removed under reduced pressure. To the residue was added ammonia hydroxide (170 mL, 25% w/v) with vigorous stirring. After being stirred for 3 h at room temperature, the mixture was filtered and washed with ammonia hydroxide (5 mL ¡Á3) and water (20 mL ¡Á5). The filter cake was recrystallized with MeOH (25 mL) to produce 14bb in 95% yield as white solid. Methyl 2-amino-3,5-dibromobenzoate (14bb) White solid, mp 89.9-91.6 C, 95% yield. 1H NMR (CDCl3) delta 8.00 (d, J = 2.1 Hz, 1H), 7.71 (d, J = 2.1 Hz, 1H), 6.38 (s, 2H), 3.91 (s, 3H). 13C NMR (CDCl3) delta 167.0, 146.6, 139.1, 133.1, 112.6, 111.1, 106.5, 52.2. MS (ESI): m/z calcd for C8H8Br2NO2: 307.9 [M+H]+; found: 308.1 (79Br, 79Br, 30%), 310.1 (79Br, 81Br 100%), 312.1 (81Br, 81Br 30%).

Statistics shows that Methyl 2-aminobenzoate is playing an increasingly important role. we look forward to future research findings about 134-20-3.

Reference:
Article; Zhao, Hong-Yi; Yang, Xue-Yan; Lei, Hao; Xin, Minhang; Zhang, San-Qi; Synthetic Communications; vol. 49; 11; (2019); p. 1406 – 1415;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics