Category: 13195-64-7

Application of 13195-64-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13195-64-7, name is Diisopropyl malonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1) sodium hydride as catalyst to 830mmol, 200mmol the diisopropyl malonate 440mmol with propargyl bromide was added to 210mL of anhydrous acetonitrile ice-water bath, the reaction was stirred for 8 hours, the product was washed with water, added with ethyl acetate, spin-dry under reduced pressure to give a tan solid product, compound 1;

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diisopropyl malonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Anhui Normal University; Hu, Yimin; Mao, Chunyan; (10 pag.)CN105523981; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 13195-64-7,Some common heterocyclic compound, 13195-64-7, name is Diisopropyl malonate, molecular formula is C9H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In 820mmol of sodium hydride as catalyst, 200mmol 440mmol diisopropyl malonate with propargyl bromide was added to 250mLof anhydrous acetonitrile in an ice-water bath with stirring for 8 hours, the product was washed with water, added with ethyl acetate, spin dried under reduced pressure, ethyl acetate: petroleumether = 1: 100 (volume ratio) as eluent column chromatography, the desired product was collected and concentrated to give a white solid product, i.e. compound a-1;

The synthetic route of 13195-64-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anhui Normal University; Lu, Shuang; Hu, Yimin; (14 pag.)CN105777679; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics