Category: 13195-64-7

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13195-64-7 as follows. HPLC of Formula: C9H16O4

General procedure: At room temperature, to a solution of nitroalkenes 2 (0.2 mmol) and chiral catalyst Q4 or QD4 in THF was added dimethyl malonate 3 (68 muL, 0.3 mmol). The resulting mixture was purified by flash chromatography when 2 was consumed through a TLC analysis to afford the product 4 or 5.

According to the analysis of related databases, 13195-64-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Li, Fei; Li, Ying-Zi; Jia, Zhen-Shan; Xu, Ming-Hua; Tian, Ping; Lin, Guo-Qiang; Tetrahedron; vol. 67; 52; (2011); p. 10186 – 10194;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 13195-64-7, name is Diisopropyl malonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13195-64-7, SDS of cas: 13195-64-7

To a stirred suspension of NaH (11.7 g, 293 mmol, 60percent purity) in DMF (100 ml) was added diisopropylmalonic ester dropwise, keeping the temperature below 40 0C. The resulting mixture was stirred for 1 h at RT and then l,3-dibromo-2,2-dimethoxypropane (34.8 g, 133 mmol) was added in one portion. The resulting mixture was heated at 140 0C for 24 h and then cooled to RT. Saturated NH4Cl aqueous (400 ml) was added and the mixture extracted with hexane (2 x 190 ml). The combined organic phases were washed with H2O (2 x 250 ml) saturated NaHCO3 (2 x 250 ml), H2O (2 x 250 ml) and brine (250 ml). The organic phase was dried (Na2SO4), filtered and concentrated at reduced pressure to provide an orange oil. Purification by in vacuo distillation to remove excess of l,3-dibromo-2,2-dimethoxypropane (b.p. 60-62 0C, 0.1 mniHg) and diisopropylmalonic ester (b.p 78-80 0C, 0.1 mmHg) provided the title compound (20 g, 52percent) as orange oil in the distillation flask. MS data: Calculated MH+ (289); Found 100percent (MH+) m/z 289.NMR data: 1H NMR (360 MHz, CHLOROFORM- d) delta ppm 5.07 (2 H, spt, J=6.3 Hz), 3.16 (6 H, s), 2.70 (4 H, s), 1.24 (12 H, d, J=6.4 Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diisopropyl malonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; EVOTEC NEUROSCIENCES GMBH; WO2009/135842; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13195-64-7, name is Diisopropyl malonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: Diisopropyl malonate

(1) 200 mmol of diisopropyl malonate was reacted with 440 mmol of propargyl bromide plus 830 mmol of sodium hydride as a catalystInto 210mL anhydrous acetonitrile in ice water bath, stirring reaction for 8 hours, the product was washed with water, extracted with ethyl acetate, dried under reduced pressure to give the product as a brown solid, namely compound 1.

The synthetic route of 13195-64-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anhui Normal University; Hu Yimin; Fang Bo; (16 pag.)CN106946707; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 13195-64-7,Some common heterocyclic compound, 13195-64-7, name is Diisopropyl malonate, molecular formula is C9H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) using 830 mmol of sodium hydride as a catalyst,200 mmol of diisopropyl malonate and 440 mmol of propargyl bromide were added to 210 mL of anhydrous acetonitrile in an ice water bath.Stir the reaction for 8 hours.The product is washed with water,Extract with ethyl acetate and spin dry under reduced pressure.Obtaining a yellow-brown solid product,That is, compound a-1

The synthetic route of 13195-64-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anhui Normal University; Yao Liangliang; Liu Baohua; Yue Hao; Han Mengyao; Hu Yimin; (15 pag.)CN110256253; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13195-64-7, name is Diisopropyl malonate, A new synthetic method of this compound is introduced below., Formula: C9H16O4

Example 1Preparation of Protected Diester 2 The dihydroisoquinoline 1 (1.0 eq.) and Boc anhydride (1.5 eq.) were dissolved in CH2Cl2 at room temperature to provide a 1.5 M solution with respect to the dihydroisoquinoline. The mixture was allowed to stir for 30 min. Following the allotted time, the reaction mixture was cooled to 0° C. and then diisopropylmalonate (1.5 eq.) followed by a pre-chilled solution of the Pd catalyst (0.008 eq.) in dichloromethane were added successively to the reaction mixture to provide a final reaction concentration of 0.84 M with respect to the starting dihydroisoquinoline. The reaction mixture was allowed to continue stirring at 2.5° C. for 15 h. Following this time EtOAc and brine were added to the reaction mixture. The aqueous layer was extracted with three portions of EtOAc and the combined organic layers were dried (Na2SO4), filtered, and concentrated under reduced pressure to provide the crude product. The crude material was dissolved in a minimal amount of dichloromethane and purified by flash chromatography on SiO2 (15-30percent EtOAc-hexanes, elution was observed at 285 nm and 228 nm). The product 2 was a colorless solid that existed as a mixture of rotamers in solution at room temperature 94percent: [alpha]26D -69.0 (c 0.21, CHCl3); 1H NMR (CDCl3) delta 0.81-1.02 (m, 6H), 1.06-1.17 (m, 6H), 1.23-1.38 (m, 9H), 2.51-2.63 (m, 1H), 2.64-2.77 (m, 1H), 3.20-3.29 (m, 0.6H), 3.32-3.41 (m, 0.4H), 3.51-3.58 (m, 1H), 3.62-3.70 (m, 6H), 3.70-3.76 (m, 0.4H), 3.91-4.01 (m, 0.6H), 4.65-4.82 (m, 1H), 4.83-4.98 (m, 1H), 5.71 (apparent d, J=5.7 Hz, 0.6H), 5.78 (apparent d, J=7.9 Hz, 0.4H), 6.42-6.49 (m, 1H), 6.77 (s, 0.6H), 6.81 (s, 0.4H); 13C NMR (CDCl3) delta 21.02, 21.09, 21.18, 21.32, 27.24, 27.95, 28.02, 37.60, 39.34, 52.11, 52.83, 55.48, 55.52, 59.28, 60.08, 68.58, 68.76, 68.82, 79.46, 80.03, 110.09, 110.73, 111.13, 126.11, 126.18, 126.37, 127.07, 146.81, 146.87, 147.93, 153.86, 154.30, 166.29, 166.78, 166.94, 167.06.

The synthetic route of 13195-64-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENERAL ELECTRIC COMPANY; US2008/306269; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 13195-64-7, name is Diisopropyl malonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13195-64-7, name: Diisopropyl malonate

(1) Using 830 mmol of sodium hydride as a catalyst,200 mmol of diisopropyl malonate with440 mmol of propargyl bromide was added to the column210 mL of anhydrous acetonitrile in ice water bath,Stirring reaction for 8 hours,The product was washed with water,Extracted with ethyl acetate,Decompression spin dry,getBrownyellowSolid product,I.e. Compound 1;

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diisopropyl malonate, and friends who are interested can also refer to it.

Reference:
Patent; Anhui Normal University; Hu Yimin; Xu Xiaoliang; (20 pag.)CN106866639; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 13195-64-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13195-64-7 name is Diisopropyl malonate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of diisopropyl malonate (500 mg, 2.65 mmol, 1 equiv) and nitroso benzene (313 mg, 2.92 mmol, 1 equiv) in absolute ethanol (1.25 mL, 2.2M), a saturated ethanolic solution of NaOH was added dropwise until the blue color of the solution turns pale brown. The reaction mixture was allowed to stir for 10 minutes and the solvent was removed under reduced pressure and the crude product was purified by column chromatography to afford 39 as viscous yellow colored oily liquid (449 mg, 61 percent).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diisopropyl malonate, and friends who are interested can also refer to it.

Reference:
Patent; WILLIAM MARSH RICE UNIVERSITY; KATTAMURI, Padmanabha Venkatesh; KURTI, Laszlo; (181 pag.)WO2018/213572; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 13195-64-7,Some common heterocyclic compound, 13195-64-7, name is Diisopropyl malonate, molecular formula is C9H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 2-(2-nitrovinyl)-phenol or 2-(2-nitrovinyl)-naphthol 1, base, Cat., and 1.5 mL solvent were added to an oven-dried tube, successively. Then malonate ester or related compound 2 and oxidant were added. The reaction mixture was then stirred in air until the reaction was nearly completed, as determined by TLC. Once 1 consumed, the reaction mixture was cooled to ambient temperature. The resulting mixture was concentrated in vacuo and directly purified by column chromatography (petroleum ether/ethyl acetate = 7:1-5:1) on silica gel to give the desired products 3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Diisopropyl malonate, its application will become more common.

Reference:
Article; Leng, Jiaying; Meng, Jiang; Luo, Xiaoyan; Deng, Wei-Ping; Tetrahedron; vol. 74; 49; (2018); p. 6993 – 6999;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 13195-64-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13195-64-7, name is Diisopropyl malonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The catalyst 10a/10b (0.01 mmol) and aldehyde 1(0.1 mmol) were dissolved in ethanol (2.0 mL). The reactionmixture was stirred for about 10 min, and then malonate2 (1.0 mmol) and triethylamine (0.2 mmol) were added atroom temperature. After vigorous stirring for about 48-72 h,the reaction mixture was poured into water (3 mL) andextracted with ethyl acetate (3 ¡Á 15 mL). The organic fractionwas dried over anhydrous MgSO4and concentratedunder reduced pressure. The crude product was purified bycolumn chromatography to afford 3a-p as desired products.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diisopropyl malonate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ashokkumar, Veeramanoharan; Siva, Ayyanar; Sankar, Balakrishnan; Journal of the Iranian Chemical Society; vol. 16; 9; (2019); p. 1939 – 1955;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 13195-64-7, name is Diisopropyl malonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13195-64-7, HPLC of Formula: C9H16O4

(1) using 830 mmol of sodium hydride as a catalyst,200 mmol of diisopropyl malonate with 440 mmolPropargyl bromide was added to 210 mL of anhydrous acetonitrile in an ice water bath.Stir the reaction for 8 hours.The product was washed with water, extracted with EtOAc EtOAc.Obtaining the product, compound 1;

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diisopropyl malonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Anhui Normal University; Zheng Xiaojie; Hu Yimin; (15 pag.)CN108947828; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics