Category: 1312703-30-2

On April 21, 2016, Lin, Wenbin; He, Chunbai; Lu, Kuangda published a patent.Recommanded Product: 1312703-30-2 The title of the patent was Nanoparticles for photodynamic therapy, x-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof. And the patent contained the following:

Metal-organic frameworks (MOFs) comprising photosensitizers are described. The MOFs can also include moieties capable of absorbing X- rays and/or scintillation. Optionally, the photosensitizer or a derivative thereof can form a bridging ligand of the MOF. Further optionally, the MOF can comprise inorganic nanoparticles in the cavities or channels of the MOF or can be used in combination with an inorganic nanoparticle. Also described are methods of using MOFs and/or inorganic nanoparticles in photodynamic therapy or in X-ray induced photodynamic therapy, either with or without the co-administration of one or more immunotherapeutic agent and/or one or more chemotherapeutic agent. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Recommanded Product: 1312703-30-2

The Article related to nanoparticle photodynamic therapy antitumor tumor radiotherapy chemotherapy immunotherapy, Pharmaceuticals: Other and other aspects.Recommanded Product: 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Carboni, Michael; Lin, Zekai; Abney, Carter W.; Zhang, Teng; Lin, Wenbin published an article in 2014, the title of the article was A Metal-Organic Framework Containing Unusual Eight-Connected Zr-Oxo Secondary Building Units and Orthogonal Carboxylic Acids for Ultra-sensitive Metal Detection.COA of Formula: C22H19NO4 And the article contains the following content:

Two metal-organic frameworks (MOFs) with Zr-oxo secondary building units (SBUs) were prepared by using p,p’-terphenyldicarboxylate (TPDC) bridging ligands pre-functionalized with orthogonal succinic acid (MOF-1) and maleic acid groups (MOF-2). Single-crystal x-ray structure anal. of MOF-1 provides the 1st direct evidence for eight-connected SBUs in UiO-type MOFs. But MOF-2 contains twelve-connected SBUs as seen in the traditional UiO MOF topol. These structural assignments were confirmed by extended x-ray absorption fine structure (EXAFS) anal. The highly porous MOF-1 is an excellent fluorescence sensor for metal ions with the detection limit of <0.5 ppb for Mn2+and three to four orders of magnitude greater sensitivity for metal ions than previously reported luminescent MOFs. The experimental process involved the reaction of Dimethyl 2'-amino-[1,1':4',1''-terphenyl]-4,4''-dicarboxylate(cas: 1312703-30-2).COA of Formula: C22H19NO4

The Article related to metal organic framework zirconium oxo orthogonal carboxylic acid, crystal structures, fluorescence sensing, functionalization, metal sensing, metal-organic frameworks, Inorganic Analytical Chemistry: Reagents and other aspects.COA of Formula: C22H19NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Wei-Hai; Yu, Xu; Liao, Wei-Ching; Sohn, Yang Sung; Cecconello, Alessandro; Kozell, Anna; Nechushtai, Rachel; Willner, Itamar published an article in 2017, the title of the article was ATP-Responsive Aptamer-Based Metal-Organic Framework Nanoparticles (NMOFs) for the Controlled Release of Loads and Drugs.Application of 1312703-30-2 And the article contains the following content:

Nanoparticles consisting of metal-organic frameworks (NMOFs) modified with nucleic acid binding strands are synthesized. The NMOFs are loaded with a fluorescent agent or with the anticancer drug doxorubicin, and the loaded NMOFs are capped by hybridization with a complementary nucleic acid that includes the ATP-aptamer or the ATP-AS1411 hybrid aptamer in caged configurations. The NMOFs are unlocked in the presence of ATP via the formation of ATP-aptamer complexes, resulting in the release of the loads. As ATP is overexpressed in cancer cells, and since the AS1411 aptamer recognizes the nucleolin receptor sites on the cancer cell membrane, the doxorubicin-loaded NMOFs provide functional carriers for targeting and treatment of cancer cells. Preliminary cell experiments reveal impressive selective permeation of the NMOFs into MDA-MB-231 breast cancer cells as compared to MCF-10A normal epithelial breast cells. High cytotoxic efficacy and targeted drug release are observed with the ATP-AS1411-functionalized doxorubicin-loaded NMOFs. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Application of 1312703-30-2

The Article related to atp controlled release nanoparticle aptamer metal organic framework, Pharmaceuticals: Formulation and Compounding and other aspects.Application of 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 14, 2015, Lin, Wenbin; He, Chunbai; Liu, Demin published a patent.HPLC of Formula: 1312703-30-2 The title of the patent was Nanoscale carriers for the delivery or co-delivery of chemotherapeutics, nucleic acids and photosensitizers. And the patent contained the following:

Nanoscale coordination polymer nanoparticles for the co-delivery of multiple therapeutic agents are described. The multiple therapeutic agents can include a combination of different chemotherapeutic agents, a combination of one or more chemotherapeutic agents and one or more nucleic acids, such as small interfering RNA (siRNA) or microRNA, a combination of one or more chemotherapeutic agents and a photosensitizer (i.e., for use in photodynamic therapy), or a plurality of different siRNAs. Pharmaceutical formulations including the nanoparticles, methods of using the nanoparticles to treat cancer, and methods of making the nanoparticles are also described. An example describes nanoscale coordination polymers made with cisplatin or oxaliplatin prodrugs and having RNAs adsorbed on the particle surface via electrostatic interactions. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).HPLC of Formula: 1312703-30-2

The Article related to nanoscale carrier delivery chemotherapeutic nucleic acid photosensitizer, Pharmaceuticals: Formulation and Compounding and other aspects.HPLC of Formula: 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Yan-An; Zhao, Xiao-Dong; Yin, Hai-Peng; Chen, Gong-Jun; Yang, Song; Dong, Yu-Bin published an article in 2016, the title of the article was A drug-loaded nanoscale metal-organic framework with a tumor targeting agent for highly effective hepatoma therapy.Computed Properties of 1312703-30-2 And the article contains the following content:

Drug delivery systems with targeting agents for precise drug release in cancer therapy are very significant and important. Herein, we report the rational design and synthesis of a DOX (doxorubicin) loaded UiO-68-type of nanoscale metal-organic framework (NMOF) with a tumor targeting agent (folic acid, FA), DOX@UiO-68-FA (3), as a multifunctional drug delivery system for hepatoma (Hep G2) therapy via tail-vein injection. Compared to free DOX, FA-unloaded DOX@Mi-UiO-68 (2), 3 exhibits a much higher antitumor efficacy, which was confirmed by cell imaging, standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) proliferation and in vivo experiments The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Computed Properties of 1312703-30-2

The Article related to metal organic framework drug delivery system preparation hepatoma therapy, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 9, 2014, He, Chunbai; Lu, Kuangda; Liu, Demin; Lin, Wenbin published an article.Related Products of 1312703-30-2 The title of the article was Nanoscale Metal-Organic Frameworks for the Co-Delivery of Cisplatin and Pooled siRNAs to Enhance Therapeutic Efficacy in Drug-Resistant Ovarian Cancer Cells. And the article contained the following:

Ovarian cancer is the leading cause of death among women with gynecol. malignancies. Acquired resistance to chemotherapy is a major limitation for ovarian cancer treatment. We report here the first use of nanoscale metal-organic frameworks (NMOFs) for the co-delivery of cisplatin and pooled small interfering RNAs (siRNAs) to enhance therapeutic efficacy by silencing multiple drug resistance (MDR) genes and resensitizing resistant ovarian cancer cells to cisplatin treatment. UiO NMOFs with hexagonal-plate morphologies were loaded with a cisplatin prodrug and MDR gene-silencing siRNAs (Bcl-2, P-glycoprotein [P-gp], and survivin) via encapsulation and surface coordination, resp. NMOFs protect siRNAs from nuclease degradation, enhance siRNA cellular uptake, and promote siRNA escape from endosomes to silence MDR genes in cisplatin-resistant ovarian cancer cells. Co-delivery of cisplatin and siRNAs with NMOFs led to an order of magnitude enhancement in chemotherapeutic efficacy in vitro, as indicated by cell viability assay, DNA laddering, and Annexin V staining. This work shows that NMOFs hold great promise in the co-delivery of multiple therapeutics for effective treatment of drug-resistant cancers. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Related Products of 1312703-30-2

The Article related to nanoscale metal organic framework cisplatin sirna ovarian cancer antitumor, Pharmaceuticals: Formulation and Compounding and other aspects.Related Products of 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 7, 2018, Lin, Wenbin; He, Chunbai; Lu, Kuangda; Ni, Kaiyuan; Lan, Guangxu published a patent.Computed Properties of 1312703-30-2 The title of the patent was Nanoparticles for photodynamic therapy, x-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof. And the patent contained the following:

Metal-organic frameworks (MOFs) comprising photosensitizers are described. The MOFs can also include moieties capable of absorbing X-rays or other ionizing irradiation energy and/or scintillation. Optionally, the photosensitizer or a derivative thereof can form a bridging ligand of the MOF. Further optionally, the MOF can comprise inorganic nanoparticles in the cavities or channels of the MOF or can be used in combination with an inorganic nanoparticle. Also described are methods of using MOFs and/or inorganic nanoparticles in photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, or in radiotherapy-radiodynamic therapy, either with or without the co-administration of one or more immunotherapeutic agent and/or one or more chemotherapeutic agent. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Computed Properties of 1312703-30-2

The Article related to mof photosensitizer nanoparticles photodynamic chemotherapy immunotherapy therapy cancer, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 19, 2019, Lin, Wenbin; He, Chunbai; Lu, Kuangda published a patent.Recommanded Product: 1312703-30-2 The title of the patent was Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof. And the patent contained the following:

Metal-organic frameworks (MOFs) comprising photosensitizers are described. The MOFs can also include moieties capable of absorbing X-rays and/or scintillation. Optionally, the photo sensitizer or a derivative thereof can form a bridging ligand of the MOF. Further optionally, the MOF can comprise inorganic nanoparticles in the cavities or channels of the MOF or can be used in combination with an inorganic nanoparticle. Also described are methods of using MOFs and/or inorganic nanoparticles in photodynamic therapy or in X-ray induced photodynamic therapy, either with or without the co-administration of one or more immunotherapeutic agent and/or one or more chemotherapeutic agent. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Recommanded Product: 1312703-30-2

The Article related to nanoparticle photodynamic therapy radiotherapy chemotherapy immunotherapy metal organic framework, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 5, 2017, Huang, Hubiao; Sato, Hiroshi; Aida, Takuzo published an article.Application In Synthesis of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate The title of the article was Crystalline Nanochannels with Pendant Azobenzene Groups: Steric or Polar Effects on Gas Adsorption and Diffusion?. And the article contained the following:

An azobenzene-containing, zirconium-based metal-organic framework (AzoMOF), upon irradiation with UV light at 365 ± 10 nm, underwent trans-to-cis isomerization of its azobenzene pendants to furnish the cis-isomer content of 21% (AzoMOF21%) in 30 min at the photostationary state and underwent backward isomerization into AzoMOF1% upon either irradiation with visible light (420-480 nm) or heating. When the cis-isomer content increased, the diffusion rate and amount of CO2 adsorbed into the nanochannels of AzoMOF decreased considerably. When erythrosine B, a polarity-probing guest, was used, it showed a red shift upon exposure of AzoMOF20%⊃EB to visible light, indicating that the interior environment of AzoMOF turns less polar as the trans-isomer content becomes higher. In sharp contrast, the adsorption profiles of AzoMOF15% and AzoMOF1% for Ar having an analogous kinetic diameter to CO2 but no quadrupole moment and a smaller polarizability were virtually identical to one another. Therefore, it is likely that CO2 experiences a dominant effect of a polar effect rather than a steric effect in the crystalline nanochannels. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Application In Synthesis of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate

The Article related to zinc mof micropore gas adsorption crystal structure, Surface Chemistry and Colloids: Solid-Gas Systems and other aspects.Application In Synthesis of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Wen-Yan; Yang, Song; Li, Yan-An; Li, Qian-Ying; Guan, Qun; Dong, Yu-Bin published an article in 2019, the title of the article was Synthesis of an MOF-based Hg2+-fluorescent probe via stepwise post-synthetic modification in a single-crystal-to-single-crystal fashion and its application in bioimaging.COA of Formula: C22H19NO4 And the article contains the following content:

Although post-synthetic modification (PSM) has been successfully applied to NMOF decoration, only a handful of PSM-based single-crystal-to-single-crystal (SCSC) examples have been reported, particularly those involving multistep MOF-based SCSC transformations. In this contribution, three new MOFs, namely, UiO-68-NCS, UiO-68-R6G and UiO-68-R6G’, were prepared via the single-crystal-to-single-crystal post-synthetic modification approach. For bioimaging, nanosized UiO-68-NCS, UiO-68-R6G, and UiO-68-R6G’ were also prepared Herein, nanosized UiO-68-R6G with a rhodamine-based fluorescence switch was found to be a highly sensitive and selective fluorescent probe for the detection of Hg2+ both in vitro and in vivo. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).COA of Formula: C22H19NO4

The Article related to mercury fluorescent probe mof single crystal bioimaging, Biochemical Methods: Spectral and Related Methods and other aspects.COA of Formula: C22H19NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics