Adding a certain compound to certain chemical reactions, such as: 1312610-07-3, name is Ethyl 7-bromobenzo[d][1,3]dioxole-4-carboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1312610-07-3, Formula: C10H9BrO4
To a solution of compound I-IXa (700 mg, 2.6 mmol) in toluene (15.0 mL), EtOH (3.0 mL)Aq. Na2CO3 (2.0 M, 1.5 mL) and 4-(methoxycarbonyl)phenylboronic acid,The mixture was stirred under a nitrogen atmosphere for 10 minutes, then Pd(Ph3P)4 (90 mg, 0.08 mmol) was added and the flask was purged three times with nitrogen.The mixture was stirred at 80 C for 10 hours.After cooling to room temperature, the reaction mixture was extracted with ethyl acetate and washed with water and brine.Solvent removal and purification of the residue on silica gel by column chromatography(eluent: PE: EtOAc = 6:1)Compound I-IXb (560 mg, yield 59%) was obtained as a yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 7-bromobenzo[d][1,3]dioxole-4-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Beijing Kaiyin Technology Co., Ltd.; Xiong Guoyu; Yang Jian; Zhou Desheng; Pan Hai; Yan Fukun; (19 pag.)CN108675998; (2018); A;,
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