Adding a certain compound to certain chemical reactions, such as: 131001-86-0, name is Methyl 2-bromo-3-methylbenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 131001-86-0, SDS of cas: 131001-86-0
25 mi (10.0 MMOL) of aqueous 0.4 M sodium carbonate solution and then 303 mg (0.26 MMOL) OF TETRAKIS (TRIPHENYLPHOSPHINE) PALLADIUM (0) are added to a solution of 2.0 g (8.7 MMOL) of methyl 2-BROMO-3-METHYLBENZOATE and 2.16 g (10.5 MMOL) of 4- (trifluoromethoxy) boronic acid in 25 ml of acetonitrile. The mixture is refluxed overnight; after cooling, the reaction medium is diluted with 50 ml of water and extracted with diethyl ether. The combined organic extracts are washed twice with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue is purified by flash chromatography (eluent : 5% of diethyl ether in hexane) to give 2.4 g (89%) of the title compound.
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Reference:
Patent; MERCK PATENT GMBH; WO2004/37806; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics