Category: 13078-21-2

Some tips on 13078-21-2

Reference of 13078-21-2, These common heterocyclic compound, 13078-21-2, name is Ethyl 2-(2-methoxyphenoxy)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference of 13078-21-2, These common heterocyclic compound, 13078-21-2, name is Ethyl 2-(2-methoxyphenoxy)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of phenols (0.3 mmol), acetone (10 ml), dimethylformamide(10 ml), ethyl chloroacetate (2.5 ml, 0.26 mmol), potassiumcarbonate (2 g) and potassium iodide (0.15 g) was heated at75 C for 12 h. Afterwards, the solid was filtered and the solventof the filtrate was removed in vacuo. The colorless liquid (4a-f)obtained was dissolved in ethanol (20 ml). A solution of potassiumhydroxide (7.2%, 5 ml) was added and stirred at room temperaturefor 1.5 h. The mixture was poured into hydrochloric acid (1 mol/L)and a white precipitate was formed. Purification by recrystallizationfrom methanol afforded the corresponding aryloxyl acid (5a-f)

The synthetic route of 13078-21-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Wenbin; He, Yi; Xu, Pei; You, Qidong; Xiao, Hong; Xiang, Hua; Bioorganic and Medicinal Chemistry; vol. 23; 15; (2015); p. 4428 – 4433;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The important role of 13078-21-2

Reference of 13078-21-2, The chemical industry reduces the impact on the environment during synthesis 13078-21-2, name is Ethyl 2-(2-methoxyphenoxy)acetate, I believe this compound will play a more active role in future production and life.

Reference of 13078-21-2, The chemical industry reduces the impact on the environment during synthesis 13078-21-2, name is Ethyl 2-(2-methoxyphenoxy)acetate, I believe this compound will play a more active role in future production and life.

General procedure: A solution of corresponding substituted ethylaryloxyacetate (3a-f, 25 mmol) in ethanol (100 mL) was treated with 10% aqueous sodium hydroxide (9 mmol). After 4 h at room temperature and evaporation under reduced pressure of ethanol, the aqueous phases were acidified at pH 4 with HCl (2 N). Removal of precipitate by filtration yielded the crude acids, which were recrystallized in ethanol to afford substituted aryloxyacetic acid 4a-f, yield 66-90%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(2-methoxyphenoxy)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhong, Yan; Xu, Yi; Zhang, Ai-Xia; Li, Xiao-Feng; Xu, Zhao-Ying; Li, Ping; Wu, Bin; Bioorganic and Medicinal Chemistry Letters; vol. 26; 10; (2016); p. 2526 – 2530;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

New downstream synthetic route of 13078-21-2

Application of 13078-21-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13078-21-2, name is Ethyl 2-(2-methoxyphenoxy)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Application of 13078-21-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13078-21-2, name is Ethyl 2-(2-methoxyphenoxy)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

rytftro-l-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-l,3- propanediol (2h): (0183) (0184) 2h (0185) Scheme 9. Synthesis of ?’r_yi zro-l-(4-hydroxy-3-methoxyphenyl)-2-(2- methoxyphenoxy)– 1 ,3-propanediol (2h). (0186) This compound was prepared according to the same literature procedure as for compound 2g. Spectral data were consistent with those reported in the literature. JH NMR (400 MHz, CDC13) delta 7.16 (dd, J = 8.2, 1.6 Hz, 1H), 7.04-6.86 (m, 5H), 6.86 (d, J = 8.2 Hz, 1H), 5.71 (b s 1H), 4.96 (d, J = 7.9 Hz, 1H), 4.06-3.97 (m, 1H), 3.90 (s, 3H), 3.87 (s, 3H), 3.73-3.58 (m, 2H), 3.48 (ddd, J = 12.0, 7.8 and 3.6 Hz, 1H), 2.78-2.73 (m, 1H). HRMS (ESI) calculated for CnHzoOeNa [M + Na]+ 343.1158, found 343.1154.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(2-methoxyphenoxy)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; WISCONSIN ALUMNI RESEARCH FOUNDATION; STAHL, Shannon, S.; COON, Joshua; RAHIMI, Alireza; ULBRICH, Arne; WO2015/138563; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics