Category: 130754-19-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 130754-19-7, name is Ethyl 2-(4-Chlorophenyl)-2,2-difluoroacetate, This compound has unique chemical properties. The synthetic route is as follows., category: esters-buliding-blocks

500 mg of ethyl 2-(4-chlorophenyl)-2,2-difluoroacetate, adding 10 mL of methanol, 10 mL of water, 560 mg (10 mmol) of potassium hydroxide, stirring at room temperature for two hours, then evaporating methanol to remove water by rotary evaporation The layer was adjusted to pH 5 with hydrochloric acid to precipitate a white solid. Filtration in vacuo gave 270 mg of 2-(4-chlorophenyl)-2,2-difluoroacetic acid white powder. Used directly in the next step of the reaction.

According to the analysis of related databases, 130754-19-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhejiang University; Yang Chunhao; Shao Jimin; Zhu Weiliang; Xu Zhijian; Wang Meng; Chen Xinhuan; Hou Chuanwei; Liu Xia; Li Bo; Chen Kaixian; (47 pag.)CN105085433; (2019); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 130754-19-7, name is Ethyl 2-(4-Chlorophenyl)-2,2-difluoroacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 130754-19-7, Safety of Ethyl 2-(4-Chlorophenyl)-2,2-difluoroacetate

Part 2. Ethyl 4-chlorophenyl-2,2-difluoroacetate (250 mg) and potassium hydroxide (300 mg) were mixed in 27 ml of ethanol and 2.4 ml of water and the reaction mixture was refluxed for four hours. The mixture was then acidified and extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous Na2 SO4 and the solvent was removed in vacuo to give a product which was dissolved in 410 mg of oxalyl chloride with catalytic amount of N,N-dimethylformamide. The mixture was stirred for two hours and excess oxalyl chloride was removed in vacuo to give 4-chlorophenyl-2,2-difluoroethanoyl chloride which was used as is for the subsequent step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 2-(4-Chlorophenyl)-2,2-difluoroacetate, and friends who are interested can also refer to it.

Reference:
Patent; The Dupont Merck Pharmaceutical Company; US5583147; (1996); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics