Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1245643-11-1, name is Methyl 3,4-diamino-5-bromobenzoate, This compound has unique chemical properties. The synthetic route is as follows., name: Methyl 3,4-diamino-5-bromobenzoate
In a sealed glassware, a mixture of intermediate 3a and intermediate 3b (75/25) (10 g; 28.39 mmol), N-boc-2,3-dihydro-lH-pyrrole (6.86 mL; 39.75 mmol) and K2CO3 (11.8 g; 85.18 mmol) in 1,4-dioxane (250 mL) was bubbled with N2. Then, PPh3(1.49 g; 5.68 mmol) and Pd(OAc)2(640 mg; 2.84 mmol) were added. The reaction mixture was heated to 100C for 5h. The reaction mixture was cooled down to rt, poured onto water and extracted with EtOAc. The organic layer was decanted, washed with brine, dried over MgS04, filtered and evaporated to dryness. The residue (21 g) was purified by chromatography over silica gel (irregular SiOH; 20-45 muiotaeta; 450 g; mobile phase: 62%> heptane, 3% MeOH (+10% NH4OH), 35% EtOAc). The pure fractions were collected and evaporated to dryness yielding 2.3 g (17%>, impure) of intermediate 16a and 8.2 g (59%) of intermediate 16a.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1245643-11-1.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; ANGIBAUD, Patrick, Rene; QUEROLLE, Olivier, Alexis, Georges; BERTHELOT, Didier, Jean-Claude; MEYER, Christophe; WILLOT, Matthieu, Philippe, Victor; MEERPOEL, Lieven; JOUSSEAUME, Thierry, Francois, Alain, Jean; (114 pag.)WO2018/178280; (2018); A1;,
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