Category: 123-29-5

In an article, author is Evans, Cameron W., once mentioned the application of 123-29-5, Computed Properties of C11H22O2, Name is Ethyl nonanoate, molecular formula is C11H22O2, molecular weight is 186.29, MDL number is MFCD00009570, category is esters-buliding-blocks. Now introduce a scientific discovery about this category.

Synthetic copolymer conjugates of docetaxel and in vitro assessment of anticancer efficacy

Docetaxel (DTX) is a widely used chemotherapy drug that is associated with numerous side effects and limited bioavailability. Macromolecular conjugates of DTX may improve drug targeting, solubility, reduce off-target toxicity, and overcome mechanisms of multidrug resistance. However, most polymer conjugates of DTX investigated to date make use of biopolymers, which are of fixed structure and are not well suited to optimisation and subsequent reaction to introduce further functionality. Here, we show the preparation of synthetic copolymer conjugates of DTX with drug loading of up to 20% w/w that also has potential for tuning backbone hydrophilicity and the number of reactive sites for conjugation. The intermediates produced are comprehensively characterised, as are the macromolecular conjugates, which are tested in the MCF-7 human breast adenocarcinoma cell line to assess toxicity and anticancer efficacy. The conjugates produced have IC50 values within one order of magnitude of DTX, as expected for slow release of DTX by ester hydrolysis. The results suggest that the system is promising for delivery of DTX and future work may examine conjugates of a wider molecular weight range, optimisation of DTX and PEG conjugation efficiency, and in vivo biodistribution.

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Application In Synthesis of Ethyl nonanoate, 123-29-5, Name is Ethyl nonanoate, SMILES is CCCCCCCCC(OCC)=O, in an article , author is Liang, Xiao, once mentioned of 123-29-5.

Copper/Palladium Bimetallic System for the Synthesis of Isobenzofuranones through [4+1] Annulation between Propiophenones and Benzoic Acids

A copper/palladium-catalyzed annulation from benzoic acids and propiophenones for the synthesis of isobenzofuranones was reported. The Cu-(2,2,6,6-tetramethylpiperidin-1-yl)oxyl system showed a great ability to activate the C-H bond on the alpha- and beta-carbons of a carbonyl group, and the in situgenerated enone intermediate in this reaction could be further transformed to construct isobenzofuranones with the catalysis of Pd(dba)(2) (dba = dibenzylideneacetone). Various isobenzofuranones could be obtained in moderate to good yields, and a great atom economy was highlighted by utilizing this method.

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