Category: 1221435-18-2

HPLC of Formula: 1221435-18-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-Bromo-1H-pyrrole-2-carbonitrile, is researched, Molecular C5H3BrN2, CAS is 1221435-18-2, about Organocatalytic enantioselective formal synthesis of bromopyrrole alkaloids via aza-Michael addition. Author is Lee, Su-Jeong; Youn, Seok-Ho; Cho, Chang-Woo.

An unprecedented organocatalytic enantioselective formal synthesis of bromopyrrole alkaloid natural products was reported. An organocatalytic aza-Michael addition using pyrroles as the N-centered nucleophile was utilized as the enantioselective step to construct the nitrogen-substituted stereogenic carbon center in bromopyrrole alkaloids in good yield and excellent enantioselectivity. The aza-Michael product was converted via lactamization using a Staudinger-type reductive cyclization to the key intermediate, which was previously used in the total synthesis of bromopyrrole alkaloid natural products.

《Organocatalytic enantioselective formal synthesis of bromopyrrole alkaloids via aza-Michael addition》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(4-Bromo-1H-pyrrole-2-carbonitrile)HPLC of Formula: 1221435-18-2.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wischang, Diana; Hartung, Jens published an article about the compound: 4-Bromo-1H-pyrrole-2-carbonitrile( cas:1221435-18-2,SMILESS:BrC1=CNC(=C1)C#N ).Formula: C5H3BrN2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1221435-18-2) through the article.

Ester-, cyano-, and carboxamide-substituted 1H-pyrroles undergo electrophilic aromatic bromination, if treated with hydrogen peroxide and sodium bromide at pH 6.2 and 20 °C. Oxidation of bromide under such conditions is catalyzed by a vanadate(V)-dependent bromoperoxidase, in a substrate/enzyme ratio of 32-63 μmol %. To obtain maximum yields of bromopyrroles (up to 91%) by spending the least amount of substrate and catalyst, hydrogen peroxide and sodium bromide have to be added continuously to the enzyme and the 2-acceptor-substituted pyrrole (1.5 m mol) in a solution of morpholine-4-ethanesulfonic acid buffer. This technique was applied to prepare two marine natural products under biomimetic conditions, i.e., Me 4,5-dibromopyrrole-2-carboxylate (from Agelas oroides) and 4,5-dibromopyrrole-2-carboxamide (from Acanthella carteri).

From this literature《Parameters for bromination of pyrroles in bromoperoxidase-catalyzed oxidations》,we know some information about this compound(1221435-18-2)Formula: C5H3BrN2, but this is not all information, there are many literatures related to this compound(1221435-18-2).

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics