Sources of common compounds: Benzyl propionate

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 122-63-4, name is Benzyl propionate, A new synthetic method of this compound is introduced below., Computed Properties of C10H12O2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 122-63-4, name is Benzyl propionate, A new synthetic method of this compound is introduced below., Computed Properties of C10H12O2

Carbapenem Intermediate (CPI) was prepared according to the synthetic scheme shown in Scheme 1. In the first step of the process, benzyl propionate is reacted with isobutoxycarbonyloxy acetic acid methyl ester in a solvent at low temperature in the presence of LDA to form ketoester A. The ketoester A is then contacted with the acetoxyazetidinone B (prepared by any number of known, synthetic routes) in a solvent, and sodium carbonate is added. The reaction ages for a period of time at a temperature such that the reaction goes substantially to completion, generating the target lactam C.

The synthetic route of 122-63-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng; WO2011/160020; (2011); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The important role of Benzyl propionate

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 122-63-4, name is Benzyl propionate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 122-63-4, Product Details of 122-63-4

To a solution of benzyl propionate (2.46 g, 15.0 mmol) in anhydrous THF (30 mL) at -78 C was added dropwise LDA (2.0 M, 7.5 mL). The mixture was stirred for 30 min, and then tert-butyl 4-oxopiperidine-l-carboxylate (3.0 g, 15.0 mmol) in anhydrous THF (20 mL) was added. This mixture was stirred at -78 C for 1 h, then quenched with sat aqueous H4CI (30 mL) and extracted with EtOAc (50 mLx3). The combined organic extracts were washed with brine and dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel column (pet ether: EtOAc 3 : 1) to give the desired product as a white solid (2.5 g). Yield 46 % (ESI 264.2 (M+H-100) +).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; LAZULI, INC.; HARRISON, Bryce, Alden; BURSAVICH, Matthew, Gregory; GERASYUTO, Aleksey, Lgorevich; HAHN, Kristopher, Neil; KONZE, Kyle, David; LIN, Fu-Yang; LIPPA, Blaise, Scott; LUGOVSKOY, Alexey, Alexandrovich; ROGERS, Bruce, Nelsen; SVENSSON, Mats, Ake; TROAST, Dawn, Marie; (0 pag.)WO2018/160522; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Introduction of a new synthetic route about 122-63-4

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Benzyl propionate, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 122-63-4, name is Benzyl propionate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 122-63-4, category: esters-buliding-blocks

Carbapenem Intermediate (CPI) 5 was prepared according to the synthetic scheme shown in FIGURE 3. In the first step of the process, benzyl propionate is reacted with isobutoxycarbonyloxy acetic acid methyl ester in a solvent at low temperature in the presence of LDA to form ketoester A.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Benzyl propionate, and friends who are interested can also refer to it.

Reference:
Patent; FOB SYNTHESIS; WO2005/123066; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics