Synthetic Route of 121591-81-9, These common heterocyclic compound, 121591-81-9, name is Methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
K2CO3 (1.79 mmol) is added to a solution of 3,4-dihydro-2H-benzo[1,4]oxazine-5-carboxylic acid methyl ester (0.78 mmol) in DMF (1.0 mL). After 30 min methyl iodide (1.55 mmol) is added and the mixture is stirred for 2 h at 75 C. Cold water and EtOAc are added, the layers are separated and the aq. layer is extracted with EtOAc. The combined organic layers are washed with water and brine, dried over MgSO4 and concentrated in vacuo to give a crude product which is used without further purification. LC-MS: tR=0.71 min; [M+H]+=208.1.
The synthetic route of 121591-81-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Actelion Phamaceuticals Ltd.; US2010/16401; (2010); A1;,
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