Category: 121-98-2

Electric Literature of 121-98-2, A common heterocyclic compound, 121-98-2, name is Methyl 4-methoxybenzoate, molecular formula is C9H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of methyl benzoates (15.0 mmol), CH3OH (30.0 mL) wereplaced in a 100mL round-bottomed flask equipped with a magnetic stirrer.Stirring for 10 minutes in 0 C. Then hydrazine hydrate (4.0 eq.) was added to the flask. Afterword the mixture was stirred under reflux 8 h, the reaction system was concentrated to remove CH3OH and most of hydrazine hydrate. After cooling, the contents were added petroleum-ether (50 mL) by stirring, then the white solids would be separated, washed with water and dried under vacuum. The yield was 65%~80%.

The synthetic route of 121-98-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Guofu; Yu, Yidong; Zhao, Yiyong; Xie, Xiaoqiang; Ding, Chengrong; Synlett; vol. 28; 11; (2017); p. 1373 – 1377;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 121-98-2, name is Methyl 4-methoxybenzoate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 121-98-2

General procedure: A mixture of substrate (1 mmol), CuBr2 (22.4 mg, 10 mol%), LiBr (130.3 mg, 1.5 equiv.), and 0.05 mL of water was placed in a 50 mL stainless steel autoclave equipped with an inner glass tube in room temperature. CO2 (4 MPa) and O2 (1 MPa) were subsequently introduced into the autoclave and the system was heated under the predetermined reaction temperature for 15 min to reach the equilibration. Then the final pressure was adjusted to the desired pressure by introducing the appropriate amount of CO2. The mixture was stirred continuously for the desired reaction time. After cooling, products were diluted with acetone and analyzed by gas chromatograph (Shimadzu GC-2014) equipped with a capillary column (RTX-17 30 m × 25 mum and RTX-wax 30 m × 25 mum) using a flame ionization detector by comparing the retention times of authentic samples. The residue was purified by column chromatography on silica gel (200-300 mesh, eluting with petroleum ether/ethyl acetate from petroleum ether to 50:1) to afford the desired product. The isolated products were further identified with NMR spectra (Bruker 400 MHz) and GC-MS or GCD, which are consistent with those reported in the literature.

According to the analysis of related databases, 121-98-2, the application of this compound in the production field has become more and more popular.

Reference:
Conference Paper; Liu, An-Hua; Ma, Ran; Zhang, Meng; He, Liang-Nian; Catalysis Today; vol. 194; 1; (2012); p. 38 – 43;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 121-98-2, name is Methyl 4-methoxybenzoate, A new synthetic method of this compound is introduced below., Computed Properties of C9H10O3

General procedure: A mixture of substrate (1 mmol), CuBr2 (22.4 mg, 10 mol%), LiBr (130.3 mg, 1.5 equiv.), and 0.05 mL of water was placed in a 50 mL stainless steel autoclave equipped with an inner glass tube in room temperature. CO2 (4 MPa) and O2 (1 MPa) were subsequently introduced into the autoclave and the system was heated under the predetermined reaction temperature for 15 min to reach the equilibration. Then the final pressure was adjusted to the desired pressure by introducing the appropriate amount of CO2. The mixture was stirred continuously for the desired reaction time. After cooling, products were diluted with acetone and analyzed by gas chromatograph (Shimadzu GC-2014) equipped with a capillary column (RTX-17 30 m × 25 mum and RTX-wax 30 m × 25 mum) using a flame ionization detector by comparing the retention times of authentic samples. The residue was purified by column chromatography on silica gel (200-300 mesh, eluting with petroleum ether/ethyl acetate from petroleum ether to 50:1) to afford the desired product. The isolated products were further identified with NMR spectra (Bruker 400 MHz) and GC-MS or GCD, which are consistent with those reported in the literature.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Conference Paper; Liu, An-Hua; Ma, Ran; Zhang, Meng; He, Liang-Nian; Catalysis Today; vol. 194; 1; (2012); p. 38 – 43;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 121-98-2 as follows. Recommanded Product: Methyl 4-methoxybenzoate

To a cooled (-20 C) solution of 4-methoxybenzoic acid methyl ester 11 (3.00 g, 18.1 mmol) in MeCN (30 mL) was added HBF4·Et2O (3.22 mL, 19.9 mmol) and then slowly added NBS (3.54 g, 19.9 mmol) under less than -10 C. After the addition, the cooling bath was removed and the reaction mixture was allowed to warm up to room temperature, and stirred for 23 h. Saturated NaHSO3 solution was then added, and the reaction mixture was extracted with EtOAc. The combined organic layers were washed with saturated NH4Cl solution and brine, dried over Na2SO4, and then concentrated in vacuo. Purification by silica gel column chromatography (hexane/EtOAc = 5/1) gave 12 (4.35 g, 17.7 mmol, 98%) as a colorless powder;

According to the analysis of related databases, 121-98-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ogura, Tetsuhiro; Usuki, Toyonobu; Tetrahedron; vol. 69; 13; (2013); p. 2807 – 2815;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 121-98-2, name is Methyl 4-methoxybenzoate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 121-98-2

General procedure: A solution of hydrazine hydrate (20.00 mmol) in 2 mL EtOH was added dropwise to the ester 2 (5.00 mmol). The mixture was refluxed for 5 h and filtered, and the corresponding acid hydrazide 3 was obtained by washing the residue with ice water.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 121-98-2.

Reference:
Article; Han, Shuang; Zhang, Fei-Fei; Xie, Xin; Chen, Jian-Zhong; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 73 – 84;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 121-98-2, These common heterocyclic compound, 121-98-2, name is Methyl 4-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The mixture of 4-methoxy methyl benzoate (33 g, 0.2 mol) and anhydrous hydrazine (7.7 g, 0.24 mmol) was heated to 140 C under nitrogen atmosphere, and reacted at the said temperature for 30 minutes. After cooled to the room temperature, the mixture was extracted with ethyl acetate (3×100 ml). The organic layer was dried over anhydrous sodium sulfate, and filtered, then concentrated under reduced pressure to give a crude product of intermediate compound 19 (30 g), which can be used for the next reaction step directly.

The synthetic route of 121-98-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beijing Foreland Biopharma Co., Ltd.; ZHANG, Xingmin; WANG, Ensi; GUO, Jing; NIU, Shengxiu; DAI, Zhuolin; ZHENG, Nan; JI, Liping; WANG, Zhenfang; LIANG, Tie; EP2860176; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 121-98-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 121-98-2 name is Methyl 4-methoxybenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Compounds 6a-t were synthesized from substituted benzoic acid via six steps according to the literature method as described. Various substituted benzoic acids 1a-t were treated with SOCl2 to give compounds 2a-t, which were reacted with CH3OH and EtN3 in CH2Cl2 at 0 to afford compounds 3a-t. Compounds 4a-t were prepared by the reaction of compounds 3a-t, hydrazine hydrate in CH3OH under reflux condition about 5h. Subsequently, compounds 5a-t were obtained by reaction of compounds 4a-t with CS2 and KOH in CH3OH. Compounds 6a-t were obtained by the cyclization reaction of compounds 5a-t in the presence of HCl at 0-5C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-methoxybenzoate, and friends who are interested can also refer to it.

Reference:
Article; Li, Liangjing; Ding, Hao; Wang, Baogang; Yu, Shichong; Zou, Yan; Chai, Xiaoyun; Wu, Qiuye; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 192 – 194;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Computed Properties of C9H10O3, 121-98-2, Name is Methyl 4-methoxybenzoate, SMILES is C1=CC(=CC=C1OC)C(OC)=O, belongs to esters-buliding-blocks compound. In a document, author is Tan, Dong-Xing, introduce the new discover.

An updated asymmetric total synthesis of (+)-tronocarpine

An updated route for the asymmetric total synthesis of (+)-tronocarpine is presented. By a careful modification of the synthetic strategies and methods for the construction of azepanone ring and for the incorporation of acetyl side group at C-20 based on our experiences for the synthesis of chippiine-dippinine type indole alkaloids, the synthesis of (+)-tronocarpine could be shortened from 15 longest linear sequences (LLSs) to 11 LLSs starting from an easily prepared intermediate. The new synthetic route presented herein would provide a more efficient synthesis of (+)-tronocarpine as well as its analogues for biological evaluation which remained unexplored due to the paucity of natural sources. (C) 2020 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 121-98-2 is helpful to your research. Computed Properties of C9H10O3.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 121-98-2, Name is Methyl 4-methoxybenzoate, SMILES is C1=CC(=CC=C1OC)C(OC)=O, in an article , author is He, Zeying, once mentioned of 121-98-2, SDS of cas: 121-98-2.

The application of in-source fragmentation in ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for pesticide residue analysis

In this study, in-source fragmentation in ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) was investigated and applied for pesticide residue analysis. Over 400 pesticides were tested, among which 26 pesticides were found to be sensitive to in-source fragmentation, producing 33 in-source fragments. The fragment pathways were studied and severe in-source fragmentation was observed due to the cleavage of C-O bond of carbamate, phosphate, ester, and ether groups, especially for isocarbophos and methoprene, leading to false negative results. High source temperatures could significantly increase the extent of in-source fragmentation. A multiple reaction monitoring (MRM) based multiresidue method was established for the pesticide residue analysis in vegetables and fruits, applying both pesticides and in-source fragments as precursors. The quantifica-tion ability of the method was validated and compared in terms of recovery, linearity, and the limit of quantification. In-source fragmentswere found to be more suitable than their parent pesticides as precursor ions for MRM analysis. (c) 2020 Published by Elsevier B.V.

Interested yet? Read on for other articles about 121-98-2, you can contact me at any time and look forward to more communication. SDS of cas: 121-98-2.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Yin, Hao, once mentioned the application of 121-98-2, Name is Methyl 4-methoxybenzoate, molecular formula is C9H10O3, molecular weight is 166.17, MDL number is MFCD00008437, category is esters-buliding-blocks. Now introduce a scientific discovery about this category, COA of Formula: C9H10O3.

Improved wet shear strength in eco-friendly starch-cellulosic adhesives for woody composites

Development of eco-friendly adhesives from renewable biomass has attracted considerable attention in recent years. Here, we present a novel approach via combination of waste newspaper (WNP) powder, oxidized glutinous rice starch, and polyamidoamine-epichlorohydrin (PAE) to prepare a formaldehyde-free starch-cellulosic adhesive (SCA) for woody composites. The oxidation treatment made the carboxyl/carbonyl groups more available in starch. Plywood bonded by the optimum SCA with 50 wt% of the WNP powder showed a wet shear strength of 0.83 MPa exceeding that of the oxidized starch adhesive by 130.5 %. During the curing process of SCA, the oxidized starch and WNP fiber participated into the crosslinking reaction with PAE via ester and ether bonds, as evidenced by FTIR analysis. The resulting cured adhesive had enhanced crystalline structures, thermal properties, hydrophobicity, wet-cohesion, rheological properties, and adhesiveness to wood. The SCA showed great potential in wood composites as an alternative to formaldehyde-derived adhesives.

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