Category: 121-79-9

Bruusgaard-Mouritsen, Maria A. published the artcileFacial contact dermatitis caused by cosmetic-relevant allergens, Product Details of C10H12O5, the publication is Contact Dermatitis (2021), 85(6), 650-659, database is CAplus and MEDLINE.

Facial allergic contact dermatitis caused by cosmetic products is common. New allergens in cosmetics continuously emerge. To investigate characteristics of patients with facial dermatitis (FD) between 2010 and 2019 including patch test results from cosmetic-related allergens and a new test series with cosmetic-relevant natural ingredients (CRNIs). This is a retrospective study analyzing demographics, clin. characteristics according to MOAHLFA index (male; occupation; atopic dermatitis; hand; leg; face; age ≥ 40 years), and patch test results to 27 cosmetic-relevant allergens in FD patients. A prospective study evaluating a screening test series with CRNIs in consecutive FD patients for 1 yr was also conducted. These patients received a questionnaire for collecting extra characteristics (eg, concerning quality of life). Of 8740 tested patients, 2292 (26.2%) had FD. Of these, 30.6% had cosmetic-induced FD. The most common cosmetic-related allergens were fragrances and preservatives. The most common patch test-pos. CRNIs were hydroperoxides of limonene and linalool, and propolis. Potato and peanut were rare, but the most common prick test-pos. CRNIs, however, without any relation to the use of cosmetic products. FD affected nearly all patients′ quality of life and caused limitations to their daily life. Updated management and quick diagnosis of FD is important to avoid neg. impact on patients′ quality of life.

Contact Dermatitis published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Product Details of C10H12O5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wei, Zhengxi published the artcileA direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers, Synthetic Route of 121-79-9, the publication is Toxicology Letters (2021), 67-77, database is CAplus and MEDLINE.

Chem.-peptide conjugation is the mol. initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatog./UV (HPLC/UV) detection method to quantify chem.-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two synthetic peptides containing lysine or cysteine residues. To improve assay throughput, sensitivity and accuracy, an automated 384-well plate-based RapidFire solid-phase extraction (SPE) system coupled with tandem mass spectrometry (MS/MS) DPRA was developed and validated in the presence of a newly designed internal standard Compared to the HPLC/UV-based DPRA, the automated SPE-MS/MS-based DPRA improved throughput from 16 min to 10 s per sample, and substrate peptides usage was reduced from 100 mM to 5μM. When implementing the SPE-MS/MS-based DPRA into a high-throughput platform, we found 10 compounds that depleted lysine peptide and 24 compounds that depleted cysteine peptide (including 7 unreported chems. from 55 compounds we tested) in a concentration-response manner. The adduct formation between cysteine and cinnamic aldehyde and ethylene glycol dimethacrylate were further analyzed using high-performance liquid chromatog. time-of-flight mass spectrometry (HPLC-TOF-MS) to confirm the conjugation. Overall, the automated SPE-MS/MS-based platform is an efficient, economic, and accurate way to detect skin sensitizers.

Toxicology Letters published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C7H5Cl2NO2, Synthetic Route of 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fathy, Samah M. published the artcileNeuroprotective effects of pomegranate (Punica granatum L.) juice and seed extract in paraquat-induced mouse model of Parkinson′s disease, Name: Propyl 3,4,5-trihydroxybenzoate, the publication is BMC Complementary Medicine and Therapies (2021), 21(1), 130, database is CAplus and MEDLINE.

Paraquat, (PQ), an herbicide that can induce Parkinsonian-like symptoms in rodents and humans. The consumption of phytochem.-rich plants can reduce the risk of chronic illnesses such as inflammation and neurodegenerative diseases. The present study aimed to investigate the protective effects of pomegranate seed extract (PSE) and juice (PJ) against PQ-induced neurotoxicity in mice. Mice were assigned into 4 groups; three groups received PQ (10 mg/kg, i.p.) twice a week for 3 wk. Two of the PQ-induced groups pretreated with either PSE or PJ. Detection of phytochems., total phenolics, and total flavonoids in PSE and PJ was performed. Tyrosine hydroxylase (TH) level was measured in the substantia nigra (SN) by Western blotting technique. Striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were detected using high-performance liquid chromatog. (HPLC). The levels of ATP (ATP), malondialdehyde (MDA), and the activity of the antioxidant enzymes were estimated in the striatum by colorimetric anal. Striatal pro-inflammatory and anti-inflammatory markers using ELISA (ELISA) as well as DNA fragmentation degree by qual. DNA fragmentation assay, were evaluated. Real-time polymerase chain reaction (qPCR) assay was performed for the detection of nuclear factor kappa B (NF-kB) gene expression. Moreover, Western blotting anal. was used for the estimation of the cluster of differentiation 11b (CD11b), transforming growth factor β (TGF-β), and glial cell-derived neurotrophic factor (GDNF) levels in the striatum. Pretreatment with PSE or PJ increased the levels of TH in the SN as well as DA and its metabolite in the striatum that were reduced by PQ injection. PSE and PJ preadministration improved the PQ-induced oxidative stress via a significant reduction of the MDA level and the augmentation of antioxidant enzyme activities. PSE and PJ also significantly downregulated the striatal NF-kB gene expression, reduced the PQ-enhanced apoptosis, decreased the levels of; pro-inflammatory cytokines, CD11b, and TGF-β coupled with a significant increase of; interleukin-10 (IL-10), GDNF, and ATP levels as compared with PQ-treated mice. The current study indicated that PSE and PJ consumption may exhibit protective effects against PQ-induced neurotoxicity in mice.

BMC Complementary Medicine and Therapies published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Name: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hou, Siyu published the artcileElucidation of the Regulatory Network of Flavonoid Biosynthesis by Profiling the Metabolome and Transcriptome in Tartary Buckwheat, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate, the publication is Journal of Agricultural and Food Chemistry (2021), 69(25), 7218-7229, database is CAplus and MEDLINE.

The characteristics of flavonoid metabolism in different Tartary buckwheat (TB) tissues and the related gene regulation network are still unclear at present. One hundred forty-seven flavonoids were identified from six TB tissues using the ultra performance liquid chromatog. tandem mass spectrometry (UPLC-MS/MS) method. The roadmap of the rutin synthesis pathway was revealed. Through transcriptomic anal. it was revealed that the differentially expressed genes (DEGs) are mainly enriched in the “Phenylpropanoid biosynthesis” pathway. Fifty-two DEGs involved in the “flavonol synthesis” pathway were identified. The weighted gene correlation network anal. revealed four co-expression network modules correlated with six flavonol metabolites. Eventually, 74 genes revealed from MEblue and MElightsteelblue modules were potentially related to flavonol synthesis. Of them, 7 MYB transcript factors had been verified to regulate flavonoid synthesis. Furthermore, overexpressed FtMYB31 enhanced the rutin content in vivo. The present findings provide a dynamic flavonoid metabolism profile and co-expression network related to rutin synthesis and are thus valuable in understanding the mol. mechanisms of rutin synthesis in TB.

Journal of Agricultural and Food Chemistry published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wolosiak, Rafal published the artcileVerification of the Conditions for Determination of Antioxidant Activity by ABTS and DPPH Assays-A Practical Approach, Application In Synthesis of 121-79-9, the publication is Molecules (2022), 27(1), 50, database is CAplus and MEDLINE.

The ABTS and DPPH methods are among the most popular assays of antioxidant activity determination Attempts to adapt them to different analytes and the search for the highest values of antioxidant activity has resulted in a large variety of assay conditions to be presented in the literature, including the way the measurement is made. This makes it difficult to relate the results to real oxidation systems, and often makes it impossible to compare them. Such a comparison is limited in advance by the use of stable radicals that do not exist in nature and that react differently from those generated in food or in vivo. Therefore, it is important to introduce measures aimed at standardizing the conditions of the activity assay, including reaction time and several reaction environments suitable for testing different groups of compounds In this study, we used natural antioxidants of various structures: phenolic acids, flavonoids, peptides and corresponding amino acids, ascorbic acid and α-tocopherol, and also synthetic analogs of selected compounds The curves of dependence of the measured absorbance on the concentration of antioxidants were described, the ranges of linearity were determined, and the value of the error made when reading in various ranges of dependencies was estimated We also determined and compared the activity values using two popular methods (IC₅₀ and TEAC), taking into account different environments and reaction times. Based on the collected data, recommendations were formulated regarding the reaction conditions adapted to the studies of individual groups of antioxidants, and unified reaction times were proposed. Taking into account the state before reaching the equilibrium of antioxidants reacting in a complex manner, this approach may introduce a simplified reference to the competing reaction that occurs in reality.

Molecules published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C12H9N3O4, Application In Synthesis of 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dey, Tanmay published the artcileApoplastic reactive oxygen species mediated escape growth of root during illumination in Vigna radiata (L.) Wilczek seedlings, Name: Propyl 3,4,5-trihydroxybenzoate, the publication is Acta Physiologiae Plantarum (2021), 43(11), 145, database is CAplus.

Besides gravity, roots are also guided by light to grow deep into the soil and sensitivity of roots to light is evidently due to presence of photoreceptors like phototropins. Such light-induced root growth (light-escape growth) presumably involves reactive oxygen species (ROS). Present study explores the possibility of ROS action in this event during early seedling growth of Vigna radiata based on pharmacol. evidences. Germinated (20 h) seeds were incubated in dark or light in presence of general ROS scavenger (Pr gallate), specific scavengers of O^·₂^– (copper chloride; CuCl₂), H₂O₂ [dimethylthiourea (DMTU) and potassium iodide (KI)] and ^·OH (sodium benzoate) and ROS-producing enzyme inhibitors [zinc chloride (ZnCl₂), inhibitor of NADPH oxidase (NOX); diethyldithiocarbamate (DEDTC), inhibitor of superoxide dismutase (SOD) and salicylhydroxamic acid (SHAM), inhibitor of peroxidase]. Light-induced root growth of 3-day seedlings diminished signifcantly in case of all the treatments suggesting for a pos. role of ROS in light-escape growth. This is supported by elevated level of apoplastic ROS in light grown roots as evident from ROS-specific staining [nitroblue tetrazolium chloride (NBT) for O^·₂^– and 3,3,5,5-tetramethylbenzidine (TMB) for H₂O₂] and spectrophotometric estimation of apoplastic ROS production (O^·₂^– and H₂O₂). In addition, higher activity of membrane bound NOX (producing O^·₂^– ) and apoplastic class III peroxidase (Prx, producing ^·OH) in light grown roots further corroborates the view that apoplastic ROS (initiated with NOX-generated O^·₂^– , which is converted, either spontaneously or by the activity of SOD, to H₂O₂ and further metabolized by Prx to ^·OH that participates in cell wall relaxation required for growth) is instrumental in light-escape growth of roots.

Acta Physiologiae Plantarum published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Name: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pellevoisin, C. published the artcilePre-validation of SENS-IS assay for in vitro skin sensitization of medical devices, Category: esters-buliding-blocks, the publication is Toxicology In Vitro (2021), 105068, database is CAplus and MEDLINE.

According to ISO 10993-1:2018, the skin sensitization potential of all medical devices must be evaluated, and for this endpoint ISO 10993-10:2010 recommends the use of in vivo assays. The goal of the present study was to determine if the in vitro SENS-IS assay could be a suitable alternative to the current in vivo assays. The SENS-IS assay uses the Episkin Large and SkinEthic RHE reconstructed human epidermis models to evaluate marker genes. In our study, the SENS-IS assay correctly identified 13 sensitizers spiked in a non-polar solvent. In a subsequent anal. six medical device silicone samples previously impregnated with sensitizers were extracted with polar and non-polar solvents. The SENS-IS assay correctly identified five of these extracts, while a sixth extract, which contained the weak sensitizer Ph benzoate, was classified as neg. However, when this extract was concentrated, or a longer exposure time was used, the assay was able to detect Ph benzoate. The SENS-IS assay was transferred to a naive laboratory which correctly identified sensitizers in six blinded silicone samples, including the one containing Ph benzoate. In light of these results, we conclude that the SENS-IS assay is able to correctly identify the presence of sensitizers in medical devices extracts

Toxicology In Vitro published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xu, Xiaoqing published the artcileSynthetic phenolic antioxidants: Metabolism, hazards and mechanism of action, SDS of cas: 121-79-9, the publication is Food Chemistry (2021), 129488, database is CAplus and MEDLINE.

A review. Synthetic phenolic antioxidants can interact with peroxides produced by food. This paper reviews correlation between BHA, BHT and TBHQ metabolism and harms they cause and provides a theor. basis for rational use of BHA, BHT and TBHQ in food, and also put some attention on the transformation and metabolic products of PG. We introduce BHA, BHT, TBHQ, PG and their possible metabolic pathways, and discuss possible harms and their specific mechanisms responsible. Excessive addition or incorrect use of synthetic phenolic antioxidants results in carcinogenicity, cytotoxicity, oxidative stress induction and endocrine disrupting effects, which warrant attention. BHA carcinogenicity is related to production of metabolites TBHQ and TQ, and cytotoxic effect of BHA is the main cause of apoptosis induction. BHT carcinogenicity depends on DNA damage degree, and tumor promotion is mainly related to production of quinone methylation metabolites. TBHQ carcinogenicity is related to induction of metabolite TQ and enzyme CYP1A1.

Food Chemistry published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C22H18O2, SDS of cas: 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xia, Yuanyuan published the artcilePreparation of cellulose beads with high homogeneity, low crystallinity, and tunable internal structure, SDS of cas: 121-79-9, the publication is Cellulose (Dordrecht, Netherlands) (2022), 29(3), 1473-1485, database is CAplus.

The preparation of cellulose beads has attracted much attention in the application of advanced green materials. Herein, the uniform and controllable cellulose beads were prepared by first dissolving the pulp into N-methylmorpholine N-oxide (NMMO), and then regenerated in various coagulation baths (water, alc., acid, NMMO, etc.). Results showed that the crystalline structure of regenerated cellulose changed from cellulose I to cellulose II. Besides, the cellulose beads regenerated in Methanol (MT-cellulose bead) had the highest porosity (90.51%) and crystallinity (62.59%). Laser confocal microscopy was employed to reveal the coagulation mechanism of cellulose beads, and the solidification process was carried out from the inside to the outside. This is a green and facile method for preparing cellulose beads with different structures and properties that can be widely used in absorbent materials, energy storage materials, and protein chromatog.

Cellulose (Dordrecht, Netherlands) published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H19NO3, SDS of cas: 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yang, Dezhi published the artcileA multifunctional nanozyme-based enhanced system for tert-butyl hydroquinone assay by surface-enhanced Raman scattering, Safety of Propyl 3,4,5-trihydroxybenzoate, the publication is Microchimica Acta (2022), 189(1), 29, database is CAplus and MEDLINE.

An Au-based nanozyme composite (AuNPs/Cu,I) was constructed by using Cu,I-doped carbon dots (Cu,I-CDs) as the reducing agent as well as the nanozyme. Notably, AuNPs/Cu,I nanozyme not only possessed the intrinsic activity of mimicking enzymes of superoxide dismutase, peroxidase, and catalase at different conditions but was also employed as surface-enhanced Raman spectroscopy (SERS) enhancer. The combination of Cu,I-CDs and AuNPs promoted the electron transferability, leading to increased peroxidase-like activity and superoxide-like activity. Compared to the individual Cu,I-CDs and AuNPs nanozyme, the AuNPs/Cu,I composite demonstrated promising peroxidase-like activity by transferring electrons instead of generating OH. Interestingly, the multienzyme-like activity of AuNPs/Cu,I nanozyme could be finely tuned by changing the composition of Cu0/Cu+ and Au. The tert-Bu hydroquinone (TBHQ) as the substrate could be catalyzed with AuNPs/Cu,I nanozyme to produce red substances, resulting in a significant Raman enhancement effect at the same time, showing good linear range from 0.11 to 10 mg L^-1. Overall, the current investigation provides a flexible and controllable way to design multifunctional nanozymes along with the Raman enhancement strategy based on the catalysis of nanozyme.

Microchimica Acta published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C6H13I, Safety of Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics