Category: 121-79-9

Rosenau, Thomas published the artcileOn the role of N-methylmorpholine-N-oxide (NMMO) in the generation of elemental transition metal precipitates in cellulosic materials, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate, the publication is Cellulose (Dordrecht, Netherlands) (2021), 28(16), 10143-10161, database is CAplus.

Several literature reports describe the role of aqueous solutions of N-methylmorpholine-N-oxide monohydrate (NMMO) as a suitable medium for the generation of transition metal (nano)particles in or on cellulosic materials and further elaborate its role as a co-reactant of the transition metal salts that are reduced to the elemental metal. However, this would assign NMMO the role of a reductant, which is in contradiction of its obvious oxidative nature. In the present study, the exemplary cases of silver, gold, and platinum salts as the precursors of the resp. metal (nano)particles in aqueous NMMO/cellulose mixtures were investigated. Naturally, NMMO did not act as a reducing agent in any case-this role was taken over by the frequently used NMMO stabilizer Pr gallate, or by cellulose itself, into which carbonyl and carboxyl groups were introduced. Also, hypochlorite-produced intermediately from chloride ions and subsequently undergoing disproportionation into chloride and chlorate-or transient N-methylene(morpholinium) ions generated from NMMO, which are in turn oxidized to formyl morpholide, can act as the corresponding reductants while the metal ions are reduced, depending on the reaction conditions. Apart from providing interesting mechanistic insights, the study points to the importance of a precise description of the composition of the chem. systems used, as well as the importance of seemingly inert auxiliaries, which turned out to be essential co-reactants in the metal (nano)particle generation.

Cellulose (Dordrecht, Netherlands) published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Degotte, Gilles published the artcilePolyhydroxybenzoic acid derivatives as potential new antimalarial agents, Formula: C10H12O5, the publication is Archiv der Pharmazie (Weinheim, Germany) (2021), 354(11), 2100190, database is CAplus and MEDLINE.

With more than 200 million cases and 400,000 related deaths, malaria remains one of the deadliest infectious diseases of 2021. Unfortunately, despite the availability of efficient treatments, we have observed an increase in people infected with malaria since 2015 (from 211 million in 2015 to 229 million in 2019). This trend could partially be due to the development of resistance to all the current drugs. Therefore, there is an urgent need for new alternatives. We have, thus, selected common natural scaffolds, polyhydroxybenzoic acids, and synthesized a library of derivatives to better understand the structure-activity relationships explaining their antiplasmodial effect. Only gallic acid derivatives showed a noticeable potential for further developments. Indeed, they showed a selective inhibitory effect on Plasmodium (IC₅₀ ∼20μM, SI > 5) often associated with interesting water solubility Moreover, this has confirmed the critical importance of free phenolic functions (pyrogallol moiety) for the antimalarial effect. Me 4-benzoxy-3,5-dihydroxybenzoate (39) has, for the first time, been recognized as a potential lead for future research because of its marked inhibitory activity against Plasmodium falciparum and its significant hydrosoly. (3.72 mM).

Archiv der Pharmazie (Weinheim, Germany) published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Formula: C10H12O5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Serqueira, Dalyelli S. published the artcileOxidative stability and corrosivity of biodiesel produced from residual cooking oil exposed to copper and carbon steel under simulated storage conditions: Dual effect of antioxidants, Safety of Propyl 3,4,5-trihydroxybenzoate, the publication is Renewable Energy (2021), 1485-1495, database is CAplus.

This work investigates the oxidative stability and corrosivity of residual cooking oil (RCO) Me biodiesel exposed to metallic coupons (copper and carbon steel) under simulated storage conditions (static immersion for 90 days within closed vessels) and the effect of antioxidants (tert-butylhydroquinone, curcumin, propylgallate, and butyl-hydroxyanisole) on biodiesel and metallic surfaces. The induction period measured during the experiment showed that all antioxidants retarded biodiesel degradation due to their antioxidant properties. Scanning-electron microscopy and X-ray diffraction of the metallic surfaces revealed the presence of oxides due to the corrosion by biodiesel in absence of antioxidants. Nevertheless, the presence of carbonaceous solids over the metallic surfaces was found which evidences the anticorrosive properties of the antioxidants, confirmed by X-Ray spectroscopy that showed increase in the content of carbon and oxygen on the surfaces. Measurements of corrosion rate also confirmed the anticorrosive action of all antioxidants. Hence, this work shows the dual properties of antioxidants acting as free radical scavengers in the RCO biodiesel as well as corrosive inhibitors, with a special performance of propylgallate, probably due to the presence of more hydroxyl groups in its structure that also may facilitate its interaction with the metallic surface.

Renewable Energy published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C8H15NO, Safety of Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhou, Chi published the artcileCharacteristics of Metabolites by Seed-Specific Inhibition of FAD2 in Brassica napus L, Related Products of esters-buliding-blocks, the publication is Journal of Agricultural and Food Chemistry (2021), 69(19), 5452-5462, database is CAplus and MEDLINE.

Fatty acid desaturase-2 (FAD2) is a key enzyme in the production of polyunsaturated fatty acids in plants. RNAi technol. can reduce the expression of FAD2 genes in Brassica napus seeds and acquire transgenic B. napus plants with a high oleic acid content, but the effect of seed-specific inhibition of FAD2 expression on B. napus seed metabolites is not clear. Here we use widely targeted metabolomics to investigate the metabolites of normal-oleic-acid rapeseed (OA) and high-oleic-acid rapeseed (HOA) seeds, resulting in a total of 726 metabolites being detected. Among them, 24 differential metabolites were significantly downregulated and 88 differential metabolites were significantly upregulated in HOA rapeseed. In further lipid profile experiments, more lipids in B. napus seeds were accurately quantified. The contents of glycolipids and phospholipids that contain C18:1 increased significantly and C18:2 decreased because FAD2 expression was inhibited. The changes in the expression of key genes in related pathways were also consistent with the changes in metabolites. The insertion site of the ihpRNA plant expression vector was reconfirmed through genomewide resequencing, and the transgenic event did not change the sequence of FAD2 genes. There was no significant difference in the germination rate and germination potential between OA and HOA rapeseed seeds because the seed-specific ihpRNA plant expression vector did not affect other stages of plant growth. This work provides a theor. and practical guidance for subsequent mol. breeding of high OA B. napus.

Journal of Agricultural and Food Chemistry published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C6H12Br2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Blom van Staden, Analike published the artcileThe effect of Aspalathus linearis (Burm.f.) R.Dahlgren and its compounds on tyrosinase and melanogenesis, Computed Properties of 121-79-9, the publication is Scientific Reports (2021), 11(1), 7020, database is CAplus and MEDLINE.

Pigmentation, a process controlled by melanogenesis, plays a vital role in protecting the skin against harmful UV rays. The level of protection is compromised in case of hypopigmentation. This study aimed to evaluate an Aspalathus linearis extract, fractions and phytoconstituents, for their efficacy on melanogenesis stimulation. Fifteen compounds were kinetically assessed against tyrosinase; the rate-limiting enzyme of melanogenesis. Aspalathin and catechin significantly (p value < 0.001) increased the enzymic rate, showing 50% stimulatory effects at 119.70 ± 2.06μg/mL and 143.30 ± 2.74μg/mL, resp., by acting as subversive substrates. Five compounds inhibited the enzyme’s activity, of which four exhibited competitive inhibition. To investigate the mol. interactions between the compounds and the active site, mol. docking was done, using tyrosinase (PBD: 2Y9X) and tyrosinase related protein 1 (PBD: 5M8P). All the compounds docked successfully with acceptable docking scores. Further quant. structure-activity relationship anal. identified potential functional groups, linked to the specific activity. The crude extract, its fractions, and compounds exhibited low antiproliferative activity with 50% cell viability at concentrations higher than 100μg/mL. Finally, both aspalathin and catechin exhibited a significant increase (4.5%) in melanin production at 119.82μg/mL and 76.92μg/mL, resp. This is the first report of A. linearis’ compounds on skin re-pigmentation.

Scientific Reports published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Computed Properties of 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xia, Wen published the artcileA recyclable cucurbit[6]uril-supported silicotungstic acid catalyst used in the esterification reaction, Application of Propyl 3,4,5-trihydroxybenzoate, the publication is Inorganica Chimica Acta (2021), 120418, database is CAplus.

The esterification reaction used to prepare Bu paraben (BP) and Pr gallate (PG) catalyzed using a cucurbit[6]uril-supported Keggin-type silicotungstic acid (Q[6]-STA) catalyst has been investigated. The Q[6]-STA catalyst has been characterized using FTIR spectroscopy, XRD, SEM, EDS, thermal anal., and surface area studies. Q[6]-STA was easy to prepare in high yield and exhibited some advantageous properties, such as high catalytic activity and its convenient recovery. Moreover, a reusability study showed that the Q[6]-STA catalyst was stable and active.

Inorganica Chimica Acta published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C8H13NO3, Application of Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Skalicka, M. published the artcileContents of Selected Elements in the Blood Serum of Broiler Chickens After Supplementation of Humic Substances, Application of Propyl 3,4,5-trihydroxybenzoate, the publication is Folia Veterinaria (2022), 66(2), 46-53, database is CAplus.

This study was conducted to determine the concentrations of mineral substances, such as: calcium (Ca), magnesium (Mg), copper (Cu), and zinc (Zn); in the blood serum of broiler chicks after supplementation of humic substances. Group 1 (G1) was supplemented with 0.7% Humac Natur Mycosorb (HNMy); G2 with 0.7% Humac Natur Monogastric (HNM); G3 with 0.3% HNMy; and the control group (GC) received a basal diet without any supplements. In the G2 group, the serum Ca level increased slightly compared to the other exptl. groups. A statistically significant decrease (P < 0.001) in the blood serum of Mg was detected in the broilers from group G2 (0.60 mmol.l^-1) and G1 (P < 0.05; 0.68 mmol.l^-1) in comparison to the GC. The Zn in the blood serum of broilers from group G2 (22.05μmol.l^-1) was significantly increased (P < 0.05) in broilers from group G2 in comparison to the control group (19.47μmol.l^-1) and G1 group (19.61μmol.l^-1). The serum Cu (12.72μmol.l^-1) was significantly increased (P < 0.001) in broilers from group G2 in comparison to the GC (10.28μmol.l^-1). In the group G1 there was a significant decrease (P < 0.05) in the level of the Cu in the blood serum (8.69μmol.l^-1) in comparison to the serum Cu in broilers from groups G3 (10.45μmol.l^-1) and G2 (12.72μmol.l^-1). The addition of Humac Natur Mycosorb (0.3% and 0.7%) in the feed caused a strong correlation in the blood serum between the Ca and Mg (r = 0.7494; r = 0.7648). The addition of 0.3% Humac Natur Mycosorb in the feed caused a high neg. correlation (r = -0.7078) in the blood serum between the Mg and Zn.

Folia Veterinaria published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C19H17N2NaO4S, Application of Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Carrillo-Varela, Isabel published the artcileMethylene blue adsorption onto hydrogels made from different Eucalyptus dissolving pulps, Related Products of esters-buliding-blocks, the publication is Cellulose (Dordrecht, Netherlands) (2022), 29(1), 445-468, database is CAplus.

Bleached kraft pulp from Eucalyptus benthamii, E. globulus and E. nitens was purified via cold caustic extraction (CCE) with 5% and 10% (w/v) NaOH and activated with dilute acid hydrolysis (samples were coded as CCE5-H and CCE10-H, resp.) to produce dissolving-grade pulp. Hydrogels from CCE5-H and CCE10-H pulps were fabricated through the N-methylmorpholine N-oxide route and tested for methylene blue (MB) adsorption. The morphol., fiber biometry, mol. and supramol. structure, thermal stability and swelling capacity were also investigated. A higher degree of crystallinity was observed for cellulose in CCE10-H hydrogels. CCE10-H hydrogels also resulted in denser structures with lower swelling than CCE5-H hydrogels. The exptl. data for MB adsorption were fitted better to the Langmuir model, which led to estimated maximum adsorption capacities of 36-51 mg/g for CCE5-H hydrogels and 27-33 mg/g for CCE10-H hydrogels. Regarding the Eucalyptus species, hydrogels fabricated from E. nitens exhibited the highest capacities for adsorption of MB. This was attributed to the lowest crystalline fractions and crystallite sizes, and the highest kink indexes and intrinsic viscosities of E. nitens dissolving pulps, which resulted in regenerated hydrogels with highest pore coverage and water absorption capacities, and better accessibility to MB particles.

Cellulose (Dordrecht, Netherlands) published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Takahashi, Daisuke published the artcileCompound screening identified gossypetin and isoquercitrin as novel inhibitors for amyloid fibril formations of Vλ6 proteins associated with AL amyloidosis, COA of Formula: C10H12O5, the publication is Biochemical and Biophysical Research Communications (2022), 22-28, database is CAplus and MEDLINE.

AL amyloidosis is a life-threatening disease characterized by the deposition of amyloidogenic Ig light chain secreted from clonal plasma cells. Here we established an in-vitro screening system of amyloid inhibition of a variable domain in λ6 light chain mutant (Vλ6), Wil, and screened a food-additive compound library to identify compounds inhibiting the fibril formation. We found gossypetin and isoquercitrin as novel inhibitors. NMR anal. showed that both compounds directly interacted with natively-folded Wil, and proteolysis experiments demonstrated that these compounds conferred proteolytic resistance, suggesting that the compounds enhance the kinetic stability of Wil. Since gossypetin and isoquercitrin specifically interacted with the protein at micromolar concentrations, these compounds could be used as lead to further develop inhibitors against AL amyloidosis.

Biochemical and Biophysical Research Communications published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C15H20O6, COA of Formula: C10H12O5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhu, Zhaoguo published the artcilePhotoelectron Spectroscopic and Computational Study of the Deprotonated Gallic Acid and Propyl Gallate Anions, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate, the publication is Journal of the American Society for Mass Spectrometry (2022), 33(8), 1355-1361, database is CAplus and MEDLINE.

Antioxidants play important roles in eliminating reactive oxygen species (ROS), which have been associated with various degenerative diseases, such as cancer, aging, and inflammatory diseases. Gallic acid (GA) and Pr gallate (PG) are well-known antioxidants and have been widely studied in vitro and in vivo. The biol. antioxidant abilities of GA and PG are related to the electronic structure of their dehydro-radicals. In this work, we report a combined photoelectron spectroscopic and computational study of the deprotonated gallic acid anion, [GA-H]-, and deprotonated Pr gallate anion, [PG – H]-. Adiabatic electron affinities of the dehydro-gallic acid radical, [GA-H]· and of the dehydro-Pr gallate radical, [PG – H]·, are measured to be 2.90 ± 0.05 eV and 2.85 ± 0.05 eV, resp., and compared to computational results.

Journal of the American Society for Mass Spectrometry published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C14H21BO2, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics