Category: 121-79-9

Detry, Pauline published the artcileDevelopment, validation and application of multi-class methods for the analysis of food additives by liquid chromatography coupled to tandem mass spectrometry, Application of Propyl 3,4,5-trihydroxybenzoate, the publication is Food Additives & Contaminants, Part A (2022), 39(8), 1349-1364, database is CAplus and MEDLINE.

Food additives are used in numerous food products and are characterised by various physicochem. properties. In European member states, their use in food is regulated by the European Union. This work aimed to develop an accurate and high-throughput anal. method enabling the simultaneous determination of additives from different functional classes to facilitate controls and generate occurrence data for exposure assessments. The QuEChERS principle was applied due to its ease of implementation and flexibility to adjust to various food matrixes. However, very polar substances could not be extracted with sufficient recoveries. Consequently, an alternative basic methanol sample-preparation methodol. was developed. After sample preparation, the obtained extracts were analyzed using ultra-high-performance liquid chromatog. coupled to tandem mass spectrometry (UHPLC-MS/MS). Overall, the developed methodol. allowed the quantification of 27 additives from the functional classes of colors, sweeteners, preservatives, and antioxidants in various foods (e.g. beverages, dairies, processed meals). The methods were also validated in terms of selectivity, linearity, matrix effect, limit of quantification, accuracy, repeatability, and intra-laboratory reproducibility. Finally, the methods were successfully applied to eighty-four actual samples. All additives were found below authorised levels. However, irregularities were spotted in labeling.

Food Additives & Contaminants, Part A published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Application of Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Jun-Hui published the artcileScreening and effect evaluation of chemical inducers for enhancing astaxanthin and lipid production in mixotrophic Chromochloris zofingiensis, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate, the publication is Journal of Applied Phycology (2022), 34(1), 159-176, database is CAplus.

A two-stage screening approach of chem. inducers was carried out to evaluate the pos. effect on enhancing astaxanthin and lipid production in mixotrophic Chromochloris zofingiensis. The results demonstrated that oxidants were able to increase the astaxanthin content high up to 11.4 mg g^-1 biomass, while pyruvic acid promoted the cell growth and increased the contents of astaxanthin and lipids up to 10.7 mg g^-1 and 66.1% dry weight The highest yield (87.0 mg L^-1) and productivity (7.3 mg L^-1 day^-1) of astaxanthin were obtained in parallel with high lipid productivity (459.0 mg L^-1 day^-1). The correlations between the dosage effect of chem. inducers and metabolites variation were further examined by statistical analyzes. Addnl., C. zofingiensis-derived lipids were estimated to be more viable and feasible as edible oils based on fatty acid characteristics assessment. The present work highlights the effective screening strategy of chem. inducers for enhancing astaxanthin and lipid production and the potential application in mixotrophic C. zofingiensis.

Journal of Applied Phycology published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Wanyi published the artcileOccurrence of synthetic phenolic antioxidants in foodstuffs from ten provinces in China and its implications for human dietary exposure, HPLC of Formula: 121-79-9, the publication is Food and Chemical Toxicology (2022), 113134, database is CAplus and MEDLINE.

Synthetic phenolic antioxidants (SPAs) are widely used as food additives to delay the oxidation rate of oils and oil products. The concentrations and compositions of SPAs in Chinese residents most popular daily foods and the resulting exposure risk of SPAs are not clear. Therefore, this study collected food samples in 13 food categories (n = 289) from 10 provinces in China. At least one of the SPAs was detected in approx. 99.7% of foodstuffs, and the concentration of ∑SPAs ranged from not detected to 7830 (geometric mean (GM): 296 ng/g wet weight). 2,6-2 tert Bu p-1,4-benzoquinone (BHT-Q) was the main transformation product, but SPAs in food tend to exist in the parent form. A significant difference between food categories was analyzed. The highest GM of ΣSPAs occurred in cereals and cereal products, which was approx. 8 times higher than that in beverages. The estimated daily intakes of ΣSPAs in Chinese preschoolers, school-age children, adults and elderly individuals were 22200, 9970, 7540 and 7700 ng/kg bw/day, resp. The exposure risks of SPAs decreased with age. This is the first simultaneous anal. of SPAs in multiple provinces and multiple categories of foodstuffs.

Food and Chemical Toxicology published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C12H10FeO4, HPLC of Formula: 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Priscillal, I. Jenisha Daisy published the artcileSynchronously activated strontium aluminate nanoflakes anchored functionalized carbon nanofiber nanocomposite for sensitive amperometric detection of food additive: Propyl gallate, Computed Properties of 121-79-9, the publication is Food Chemistry (2022), 133119, database is CAplus and MEDLINE.

The contemporary dietary pattern is ruined by taste enhancers, flavoring agents, and preservatives. Pr gallate (PG) is an imperative phenolic antioxidant cast-off to inhibit the oxidative mutilation in foodstuffs thereby preventing rancidity. Determination and annihilation of PG are extensively concerned because of its probable lethal effects on human well-being. Herein, we report an electrochem. sensor using SrAl2O4/f-CNF nanocomposite as an efficient electrode modifier with peculiar synergistic quantum confinement effects supporting the formation of heterojunction to facilitate electron transportation between its counterparts. The structural, morphol., and crystalline features of SrAl2O4/f-CNF nanocomposite was thoroughly examined The proposed sensor possesses a wide linear range (0.1-1104.75μM) with a remarkably low limit of detection (0.075μM) and sensitivity (1.142μA·μM^-1·cm^-2) measured at 0.2 V (vs. Ag/AgCl). The reliability of this sensor was evidenced through real-time monitoring of PG in edible oil which is beneficial for food quality monitoring and dropping the danger of abuse of PG in foods.

Food Chemistry published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Computed Properties of 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yang, Pan published the artcileExposure profiles and predictors of a cocktail of environmental chemicals in Chinese men of reproductive age, Product Details of C10H12O5, the publication is Chemosphere (2022), 134337, database is CAplus and MEDLINE.

Personal care products, such as additives, have raised widespread concerns about the potential threat to male reproductive health. The spermatogenesis in humans lasts for approx. 90 days, the average levels of these chems. remain unclear during spermatogenesis. In our study, we pooled urine samples from each man during the days of 1-15, 16-31, 32-63, and ≥64, and examined exposure to 48 typical additive chems. By principal component anal. (PCA), k-means clustering, and Spearman’s rank correlations, we then identified 6 PC scores and 4 clusters based on profiles of these chems. Some industrial, com. or structural similar chems. (e.g., phthalates) were significantly correlated compared to unrelated chems. (e.g., benzophenone). PCA scores were associated with individual lifestyles (e.g., household income, tea consumption, and drinking tap water). Distinct exposure components and exposure patterns of personal care products may help the reproductive health assessment of men. We suggested more concerns for widespread exposure to these chems. for men.

Chemosphere published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C3H6F3N, Product Details of C10H12O5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jenic, Darko published the artcileReversal of Tetracycline Resistance by Cepharanthine, Cinchonidine, Ellagic Acid and Propyl Gallate in a Multi-drug Resistant Escherichia coli, Application of Propyl 3,4,5-trihydroxybenzoate, the publication is Natural Products and Bioprospecting (2021), 11(3), 345-355, database is CAplus and MEDLINE.

Bacterial resistance to antibiotics is an increasing threat to global healthcare systems. We therefore sought compounds with potential to reverse antibiotic resistance in a clin. relevant multi-drug resistant isolate of Escherichia coli (NCTC 13400). 200 natural compounds with a history of either safe oral use in man, or as a component of a traditional herb or medicine, were screened. Four compounds; ellagic acid, Pr gallate, cinchonidine and cepharanthine, lowered the min. inhibitory concentrations (MICs) of tetracycline, chloramphenicol and tobramycin by up to fourfold, and when combined up to eightfold. These compounds had no impact on the MICs of ampicillin, erythromycin or trimethoprim. Mechanistic studies revealed that while cepharanthine potently suppressed efflux of the marker Nile red from bacterial cells, the other hit compounds slowed cellular accumulation of this marker, and/or slowed bacterial growth in the absence of antibiotic. Although cepharanthine showed some toxicity in a cultured HEK-293 mammalian cell-line model, the other hit compounds exhibited no toxicity at concentrations where they are active against E. coli NCTC 13400. The results suggest that phytochems. with capacity to reverse antibiotic resistance may be more common in traditional medicines than previously appreciated, and may offer useful scaffolds for the development of antibiotic-sensitizing drugs.

Natural Products and Bioprospecting published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Application of Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tanaka, Yuji published the artcileGallic Acid Derivatives Propyl Gallate and Epigallocatechin Gallate Reduce rRNA Transcription via Induction of KDM2A Activation, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate, the publication is Biomolecules (2022), 12(1), 30, database is CAplus and MEDLINE.

We previously reported that lysine-demethylase 2A (KDM2A), a Jumonji-C histone demethylase, is activated by gallic acid to reduce H3K36me2 levels in the rRNA gene promoter and consequently inhibit rRNA transcription and cell proliferation in the breast cancer cell line MCF-7. Gallic acid activates AMP-activated protein kinase (AMPK) and increases reactive oxygen species (ROS) production to activate KDM2A. Esters of gallic acid, Pr gallate (PG) and epigallocatechin gallate (EGCG), and other chems., reduce cancer cell proliferation. However, whether these compounds activate KDM2A has yet to be tested. In this study, we found that PG and EGCG decreased rRNA transcription and cell proliferation through KDM2A in MCF-7 cells. The activation of both AMPK and ROS production by PG or EGCG was required to activate KDM2A. Of note, while the elevation of ROS production by PG or EGCG was limited in time, it was sufficient to activate KDM2A. Importantly, the inhibition of rRNA transcription and cell proliferation by gallic acid, PG, or EGCG was specifically observed in MCF-7 cells, whereas it was not observed in non-tumorigenic MCF10A cells. Altogether, these results suggest that the derivatization of gallic acid may be used to obtain new compounds with anti-cancer activity.

Biomolecules published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C6H13I, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bednar, Victor Bradley published the artcileA thermosensitive material coated resonant stent for drug delivery on demand, Quality Control of 121-79-9, the publication is Biomedical Microdevices (2021), 23(1), 18, database is CAplus and MEDLINE.

An electromagnetic energy source in the radio-frequency range delivers power to a stent circuit via resonant inductive coupling, allowing a thermally triggered release of gel via Joule heating. A gold-electroplated, medical-grade stainless steel stent, serving as the base of the prototype device, melts a coating made from an emulsion composed mainly of dodecanoic acid. These coated devices produce wirelessly controllable releases of a gel into thermally regulated, stirred water that is near body temperature The gel is made from salt, water, and gelatine from porcine skin and used to simulate drug release in this study. Thus, this system serves as a proof of concept to show the viability of controlling local drug delivery using this prototype device. Dodecanoic acid, a fatty acid, has a phase transition from solid to liquid near 43°C and has relatively good biocompatibility. The average melting temperature of two different emulsions was 40.8 ± 0.7°C, a suitable value for the targeted application. Demonstration of controllable releases used electromagnetic pulses of approx. 180 s in duration, illustrating reproducibility of a controllable release phase while remaining relatively inert in the absence of stimuli. Releases were observable through measuring the conductivity of the water, the water temperature, and the stent temperature This electrothermally active stent device enables wirelessly controlled local delivery with controlled dosage and timing, a concept with a wide range of potential applications. Some relevant examples include inhibiting restenosis or cancer treatment via targeted chemotherapy.

Biomedical Microdevices published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Quality Control of 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Skwierczynska, Malgorzata published the artcileRatiometric Upconversion Temperature Sensor Based on Cellulose Fibers Modified with Yttrium Fluoride Nanoparticles, Formula: C10H12O5, the publication is Nanomaterials (2022), 12(11), 1926, database is CAplus and MEDLINE.

In this study, an optical thermometer based on regenerated cellulose fibers modified with YF₃: 20% Yb³⁺, 2% Er³⁺ nanoparticles was developed. The presented sensor was fabricated by introducing YF₃ nanoparticles into cellulose fibers during their formation by the so-called Lyocell process using N-methylmorpholine N-oxide as a direct solvent of cellulose. Under near-IR excitation, the applied nanoparticles exhibited thermosensitive upconversion emission, which originated from the thermally coupled levels of Er³⁺ ions. The combination of cellulose fibers with upconversion nanoparticles resulted in a flexible thermometer that is resistant to environmental and electromagnetic interferences and allows precise and repeatable temperature measurements in the range of 298-362 K. The obtained fibers were used to produce a fabric that was successfully applied to determine human skin temperature, demonstrating its application potential in the field of wearable health monitoring devices and providing a promising alternative to thermometers based on conductive materials that are sensitive to electromagnetic fields.

Nanomaterials published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C4H3Cl2N3, Formula: C10H12O5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Yukun published the artcileThe High Complexity of Plastic Additives in Hand Wipes, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate, the publication is Environmental Science & Technology Letters (2021), 8(8), 639-644, database is CAplus.

Extensive and long-term applications have resulted in global distributions of plastic additives (PAs). To facilitate the understanding of human exposure to PAs, the present study investigated the abundances and profiles of a broad range of PAs on human hands via hand wipe sampling. Sixty out of 160 PAs were detected in >50% of hand wipes collected from 30 children and 45 adults, among which a number of organophosphate esters (OPEs) and synthetic antioxidants that have rarely or never been investigated in prior studies. The total masses of PAs ranged from 650 to 87 030 ng (median: 6110 ng) and 1230 to 19360 ng (median: 5600 ng) in adultsâ€?and children′s hand wipes, resp. By categories, phthalates (PAEs) represented the most abundant group of PAs, followed by non-PAE plasticizers, UV stabilizers, OPEs, antioxidants, and bisphenol analogs. Children exhibited greater PA levels per square centimeter of hand surface, indicating elevated exposure compared with adults. Strong correlations existed for many PAs between adults and children or within each subpopulation, indicating close connections between the two subpopulations in the exposure profiles. The great complexity of plastic additives on hands raises the need for future investigations on human exposure pathways and potential health risks from the “cocktail” effects.

Environmental Science & Technology Letters published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics