Category: 120974-97-2

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 120974-97-2 as follows. name: (E)-Methyl 2-(methoxyimino)-2-(o-tolyl)acetate

1.5 1 of 25% strength ammonia water are added to 120 g (0.5 mol) of methyl E-2-methoximino-2-(2-methylphenyl)-acetate in 1.5 l of methanol and the mixture is refluxed for 5 hours. The reaction mixture is then allowed to cool, concentrated to approximately 1l, stirred with water and extracted by shaking with ethyl acetate. The organic phase is washed with water, dried over sodium sulphate and concentrated in vacuo. The residue is stirred with diisopropyl ether, filtered off with suction and dried. 66.2 g (69% of theory) of E-2-methoximino-2-(2-methylphenyl)-acetamide of melting point 98-99 C. are obtained.

According to the analysis of related databases, 120974-97-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bayer Aktiengesellschaft; US6194464; (2001); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120974-97-2, name is (E)-Methyl 2-(methoxyimino)-2-(o-tolyl)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: esters-buliding-blocks

(1) Methyl-(E)-2-(2-tolyl)-2-methoxyiminoacetate (4.74 g) was dissolved in carbon tetrachloride (100 ml), and N-bromosuccinimide (4.89 g) and benzoylperoxide (554 mg) were added thereto. The resultant mixture was heated under reflux for 1 hour and cooled to room temperature. Insoluble materials were removed by filtration. On concentration of the solvent, the residue was purified by silica gel column chromatography with a mixture of hexane and ethyl acetate to give methyl-(E)-2-(2-bromomethylphenyl)-2-methoxyiminoacetate (6.98 g). 1 H-NMR: 3.89 (3H, s), 4.07 (3H, s), 4.34 (2H, s), 7.13-7.17 (1H, m), 7.34-7.47 (3H, m).

The synthetic route of 120974-97-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shionogi Seiyaku Kabushiki Kaisha; US5185342; (1993); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 120974-97-2, name is (E)-Methyl 2-(methoxyimino)-2-(o-tolyl)acetate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C11H13NO3

To the solution of IV (5 g, 24.0 mmol) in CCl4 (150 mL) was added NBS (4.7 g, 26.4 mmol) andBPO (1 g, 4.13 mmol). The reaction mixture was heated to reflux until the starting material had beencompletely consumed as judged by TLC. The precipitate was filtered off, and the solvent wasevaporated under reduced pressure. The residue was purified by a silica-gel column chromatography(petroleum ether/EtOAc = 15:1) to give (E)-methyl 2-(2-(bromomethyl)phenyl)-2-(methoxyimino)-acetate (V). Yield 85%; Yellow oil; 1H-NMR (CDCl3) delta 7.47-7.13 (m, 4H, Ar-H), 4.32 (s, 2H, CH2),4.04 (s, 3H, OCH3), 3.85 (s, 3H, OCH3). Anal. calcd for C11H12BrNO3: C 46.18, H 4.23, N 4.90; foundC 46.32, H 4.21, N 4.88.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 120974-97-2.

Reference:
Article; Liu, Yuanyuan; Li, Yi; Chen, Nanqing; Lv, Kunzhi; Zhou, Chao; Xiong, Xiaohui; Li, Fangshi; Molecules; vol. 19; 6; (2014); p. 8140 – 8150;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics