Category: 1206550-93-7

On February 4, 2010, Mikamiyama, Hidenori; Ni, Chiyou; Shao, Bin; Tafesse, Laykea published a patent.Application In Synthesis of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate The title of the patent was Preparation of tetrahydropyridine and dihydropyrrole compounds as calcium channel blockers for treatment of pain and other disorders. And the patent contained the following:

The invention relates to tetrahydropyridinyl and dihydropyrrolyl compounds of formula I (wherein X = CO, CH2, or is part of a bridge; R9 = H or is part of a bridge; Hy = a 6- or 5-membered heteroaromatic ring, or a 5-membered heterocyclic ring; Z = SO2-aryl; SO2-cycloalkenyl, CH2-aryl, etc.; R1 = CN, OH-alkyl, CO2H, etc.; R2 = alkyl, alkenyl, alkynyl, etc.; m = 0-3; n = 0-1) and pharmaceutically acceptable salts, prodrugs, or solvates thereof. The invention is also directed to the use of compounds of formula I to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain. Exemplary methods for synthesizing compounds of the invention were described, e.g., II was prepared by a multi-step synthesis involving the preparation of intermediate N-cyclopropyl-6-(1,2,3,6-tetrahydropyridin-4-yl)picolinamide and subsequent reaction with 4-trifluoromethoxybenzaldehyde to give II. Compounds of the invention were tested as N-type calcium channel (NTCC) blockers, and II demonstrated an IC50 value of 0.03 μM. II was also tested in the calcium mobilization assay for L-type calcium channel (LTCC) blocking activity and it showed an LTCC IC50 value of >20 μM in that assay. The experimental process involved the reaction of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate(cas: 1206550-93-7).Application In Synthesis of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate

The Article related to tetrahydropyridine dihydropyrrole compound preparation pain calcium channel disorder treatment, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 14, 2022, Cheng, Fei; Chen, Tao; Huang, Yin-Qiu; Li, Jia-Wei; Zhou, Chen; Xiao, Xiao; Chen, Fen-Er published an article.Category: esters-buliding-blocks The title of the article was Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters. And the article contained the following:

Authors have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale. The experimental process involved the reaction of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate(cas: 1206550-93-7).Category: esters-buliding-blocks

The Article related to aryl ester preparation copper catalyst, arylhalide malonate tandem ullmann type coupling decarboxylation, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 5, 2018, Lundgren, Rylan; Moon, Patrick published a patent.Safety of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate The title of the patent was Oxidative coupling of aryl boron reagents with sp3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis. And the patent contained the following:

Described herein are methods of oxidative coupling of aryl boron reagents with sp3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis. A method for arylation of an sp3 carbon nucleophile, comprising: reacting (a) an arylboroxine or a compound Ar-B(OR)2, wherein R=alkyl; (b) an sp3-carbon nucleophile; (c) a copper based stoichiometric promoter, and (d) triethylamine; as well as a method for decarboxylative carbonyl α-arylation, comprising: reacting (1) an aryl coupling partner; (b) a carboxylic acid, and (c) a copper based catalyst, are claimed. Example compound I was prepared by decarboxylative arylation of monoethyl malonate with 3-iodophenyl neopentyl boronic ester. The experimental process involved the reaction of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate(cas: 1206550-93-7).Safety of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate

The Article related to oxidative coupling aryl boron reagent carbon nucleophile copper catalyst, decarboxylative arylation mono malonate ester oxidative catalysis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.Safety of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 26, 2016, Moon, Patrick J.; Yin, Shengkang; Lundgren, Rylan J. published an article.Recommanded Product: Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate The title of the article was Ambient Decarboxylative Arylation of Malonate Half-Esters via Oxidative Catalysis. And the article contained the following:

We report decarboxylative carbonyl α-arylation by coupling of arylboron nucleophiles with malonic acid derivatives This process is enabled by the merger of aerobic oxidative Cu catalysis with decarboxylative enolate interception reminiscent of malonyl-CoA reactivity in polyketide biosynthesis. This method enables the synthesis of monoaryl acetate derivatives containing electrophilic functional groups that are incompatible with existing α-arylation reactivity paradigms. The utility of the reaction is demonstrated in drug intermediate synthesis and late-stage functionalization. The experimental process involved the reaction of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate(cas: 1206550-93-7).Recommanded Product: Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate

The Article related to monoaryl acetate preparation, decarboxylative arylation coupling arylboron nucleophile malonic acid, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.Recommanded Product: Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 16, 2010, Peng, Zhi-Yong; Wang, Jian-Ping; Cheng, Jiang; Xie, Xiao-min; Zhang, Zhaoguo published an article.HPLC of Formula: 1206550-93-7 The title of the article was Water works: an efficient palladium-catalyzed cross-coupling reaction between boronic acids and bromoacetate with aminophosphine ligand. And the article contained the following:

Water greatly restrained the formation of self-coupling of boronic acids in a palladium-catalyzed cross-coupling reaction between boronic acids and Et bromoacetate with an aminophosphine ligand; good to excellent yields of cross-coupling product were obtained. The experimental process involved the reaction of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate(cas: 1206550-93-7).HPLC of Formula: 1206550-93-7

The Article related to palladium aminophosphine catalyst cross coupling boronic acid bromoacetate, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.HPLC of Formula: 1206550-93-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics