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Silano, Vittorio’s team published research in EFSA Journal in 2020 | CAS: 119-36-8

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.HPLC of Formula: 119-36-8

《Safety assessment of the process Carton Pack, based on Starlinger deCON technology, used to recycle post-consumer PET into food contact materials》 was written by Silano, Vittorio; Barat Baviera, Jose Manuel; Bolognesi, Claudia; Chesson, Andrew; Cocconcelli, Pier Sandro; Crebelli, Riccardo; Gott, David Michael; Grob, Konrad; Lambre, Claude; Mengelers, Marcel; Mortensen, Alicja; Riviere, Gilles; Steffensen, Inger-Lise; Tlustos, Christina; Van Loveren, Henk; Vernis, Laurence; Zorn, Holger; Dudler, Vincent; Milana, Maria Rosaria; Papaspyrides, Constantine; Tavares Pocas, Maria de Fatima; Lioupis, Alexandros; Lampi, Evgenia; EFSA Panel on Food Contact Materials, Enzymes and Processing Aids. HPLC of Formula: 119-36-8 And the article was included in EFSA Journal in 2020. The article conveys some information:

The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process Carton Pack (EU register number RECYC188), which uses the Starlinger deCON technol. The input material is hot washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post-consumer PET containers, e.g. bottles, including no more than 5% PET from non-food consumer applications. The flakes are preheated before being submitted to solid-state polycondensation (SSP) in a continuous reactor at high temperature under vacuum and gas flow. Having examined the challenge test provided, the Panel concluded that the preheating (step 2) and the decontamination in the continuous SSP reactor (step 3) are critical in determining the decontamination efficiency of the process. The operating parameters to control the performance of these critical steps are temperature, pressure, residence time and gas flow rate. It was demonstrated that this recycling process is able to ensure a level of migration of potential unknown contaminants into food below the conservatively modelled migration of 0.1μg/kg food. Therefore, the Panel concluded that the recycled PET obtained from this process is not considered to be of safety concern, when used at up to 100% for the manufacture of materials and articles for contact with all types of foodstuffs for long-term storage at room temperature, with or without hot-fill. Trays made of this recycled PET are not intended to be used in microwave and conventional ovens and such uses are not covered by this evaluation. In addition to this study using Methyl Salicylate, there are many other studies that have used Methyl Salicylate(cas: 119-36-8HPLC of Formula: 119-36-8) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Poitou, Xavier’s team published research in Food Chemistry in 2021 | CAS: 119-36-8

Poitou, Xavier; Redon, Pascaline; Pons, Alexandre; Bruez, Emilie; Deliere, Laurent; Marchal, Axel; Cholet, Celine; Geny-Denis, Laurence; Darriet, Philippe published an article in 2021. The article was titled 《Methyl salicylate, a grape and wine chemical marker and sensory contributor in wines elaborated from grapes affected or not by cryptogamic diseases》, and you may find the article in Food Chemistry.Electric Literature of C8H8O3 The information in the text is summarized as follows:

Me salicylate (MeSA) is a plant metabolite that induces plant defense resistance and an odorous volatile compound presenting green nuances. This volatile compound was shown to be present in wine samples, sometimes at concentrations above its olfactory detection threshold. MeSA is localized in grapes, particularly in the skins and stems, and is extracted during red wine vinification. It was detected at the highest concentrations in wines of several grape varieties, made from grapes affected by cryptogamic diseases, namely downy mildew caused by Plasmopara viticola, and black rot caused by Guignardia bidwellii. It has also been detected in wines from vines affected by Esca, a Grapevine Trunk Disease. MeSA can also be considered to be a chem. marker in grapes and wine indicative of the level of development of several vine cryptogamic diseases. The results came from multiple reactions, including the reaction of Methyl Salicylate(cas: 119-36-8Electric Literature of C8H8O3)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Silano, Vittorio’s team published research in EFSA Journal in 2020 | CAS: 119-36-8

Electric Literature of C8H8O3In 2020 ,《Safety assessment of process technoplastika prima perdana, based on starlinger deCON technology, used to recycle post-consumer PET into food contact materials》 was published in EFSA Journal. The article was written by Silano, Vittorio; Barat Baviera, Jose Manuel; Bolognesi, Claudia; Chesson, Andrew; Cocconcelli, Pier Sandro; Crebelli, Riccardo; Gott, David Michael; Grob, Konrad; Lambre, Claude; Mengelers, Marcel; Mortensen, Alicja; Riviere, Gilles; Steffensen, Inger-Lise; Tlustos, Christina; Van Loveren, Henk; Vernis, Laurence; Zorn, Holger; Dudler, Vincent; Milana, Maria Rosaria; Papaspyrides, Constantine; Tavares Pocas, Maria de Fatima; Lioupis, Alexandros; Lampi, Evgenia. The article contains the following contents:

The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process Technoplastika Prima Perdana (EU register number RECYC185), which uses the Starlinger deCON technol. The input material is hot washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post-consumer PET containers, e.g. bottles, including no more than 5% PET from non-food consumer applications. The flakes are preheated before being submitted to solid-state polycondensation (SSP) in a continuous reactor at high temperature under vacuum and gas flow. Having examined the challenge test provided, the Panel concluded that the preheating (step 2) and the decontamination in the continuous SSP reactor (step 3) are critical in determining the decontamination efficiency of the process. The operating parameters to control the performance of these critical steps are temperature, pressure, residence time and gas flow rate. It was demonstrated that this recycling process is able to ensure a level of migration of potential unknown contaminants into food below the conservatively modelled migration of 0.1μg/kg food. Therefore, the Panel concluded that the recycled PET obtained from this process is not considered to be of safety concern, when used at up to 100% for the manufacture of materials and articles for contact with all types of foodstuffs for long-term storage at room temperature, with or without hot-fill. Trays made of this recycled PET are not intended to be used in microwave and conventional ovens and such uses are not covered by this evaluation. The experimental part of the paper was very detailed, including the reaction process of Methyl Salicylate(cas: 119-36-8Electric Literature of C8H8O3)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Xiangyang’s team published research in Food Chemistry in 2021 | CAS: 119-36-8

《Changes of volatile compounds and odor profiles in Wuyi rock tea during processing》 was written by Guo, Xiangyang; Ho, Chi-Tang; Wan, Xiaochun; Zhu, Hui; Liu, Qiong; Wen, Zhen. SDS of cas: 119-36-8This research focused onWuyi rock tea Odor profile favor Odor activity value; Sensory evaluation Tea processing; Odor activity value (OAV); Odor profile; Rock flavor; Sensory evaluation; Tea processing; Wuyi rock tea. The article conveys some information:

Wuyi rock tea (WRT), is one kind of oolong tea and widely appreciated for its typical ′rock flavor′. The odor characteristics of WRT during processing were comprehensive investigated by gas chromatog.-mass spectrometry, sensory evaluation and odor activity value (OAV). Alcs., alkenes and esters were the main volatiles formed during tea processes, but the WRT contained more heterocyclic compounds, among which 15 N-containing volatiles were newly identified in this study, accounting for 60.52% of total amounts of volatiles in WRT. In response, the original green and chem. odors converted to roasted and woody odors, and full fire processing was effective to enhance roasted, floral and woody odors, weaken chem. odor. 2-Ethyl-3,5-dimethylpyrazine (OAV 4.71) was confirmed as the aroma-active compound of WRT with roasted odor by aroma recombination experiment In addition, strong roasted, floral and moderate woody odors were perceived as the outline of ′rock flavor′ in WRT aroma. These results provide theor. basis for processing and quality control of WRT.Methyl Salicylate(cas: 119-36-8SDS of cas: 119-36-8) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Yun’s team published research in Translational Research in 2021 | CAS: 119-36-8

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Formula: C8H8O3

Wu, Yun; Chen, Annabel W.; Goodnough, Candida L.; Lu, Yao; Zhang, Ye; Gross, Eric R. published an article in 2021. The article was titled 《IcyHot analgesic topical cream limits cardiac injury in rodents》, and you may find the article in Translational Research.Formula: C8H8O3 The information in the text is summarized as follows:

Little is known whether topical analgesic creams, whose natural products enter the blood stream after application, affect myocardial infarct size. Here we tested whether topical analgesic creams can trigger remote cardioprotection and the mechanism involved. Male Sprague Dawley rats were used for an in vivo rodent model consisting of 30 min left anterior descending coronary artery ischemia and 2 h of reperfusion followed by infarct size assessment. The topical analgesic IcyHot, applied to the abdomen prior to ischemia, reduced myocardial infarct size vs. control (41 ± 3* vs 62 ± 1, n= 6/group, *P < 0.001). In contrast, the topical analgesic creams Preparation H, Aspercreme Heat, or Tiger Balm did not alter infarct size. IcyHot, unlike Preparation H, increased circulating Me salicylate levels during reperfusion (3.0 ± 0.6 vs 0.4 ± 0.2 mg/dL, n = 6, *P < 0.001, measured at the internal jugular vein). Me salicylate (10μM) applied to isolated adult cardiac myocytes during reoxygenation reduced cell death when compared to vehicle (21% ± 2%* vs 30% ± 2% of trypan blue pos. cells, n = 9/group, *P < 0.01). Further, treatment with the TRP ankyrin 1 (TRPA1) inhibitors TCS-5861528 (1μM) or AP-18 (1μM) blocked the Me salicylate-induced protective effect in isolated adult cardiomyocytes. In intact rodents, either of the TRPA1 inhibitors (1 mg/kg, i.v.) given prior to IcyHot topical application blocked IcyHot-induced infarct size reduction IcyHot also reduced infarct size when applied 24 h prior to myocardial ischemia or during myocardial ischemia vs. control. Together, these findings support IcyHot analgesic cream can trigger remote cardioprotection through releasing Me salicylate into the bloodstream with cardioprotection occurring by a TRPA1-dependent mechanism. In the experiment, the researchers used many compounds, for example, Methyl Salicylate(cas: 119-36-8Formula: C8H8O3)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brosnan, Robert J.’s team published research in Pharmacology in 2022 | CAS: 119-36-8

In 2022,Brosnan, Robert J.; Ramos, Kimberly; Aguiar, Antonio Jose de Araujo; Cenani, Alessia; Knych, Heather K. published an article in Pharmacology. The title of the article was 《Anesthetic Pharmacology of the Mint Extracts L-Carvone and Methyl Salicylate》.Quality Control of Methyl Salicylate The author mentioned the following in the article:

Introduction: Hydrocarbons with sufficient water solubility allosterically modulate anesthetic-sensitive ion channels. Mint extracts L-carvone and Me salicylate water solubility exceeds modulation cutoff values for γ-amino butyric acid type A (GABAA) receptors, N-methyl-D-aspartate (NMDA) receptors, and type-2 voltage-gated sodium (Nav1.2) channels. We hypothesized that mint extracts modulate these channels at concentrations that anesthetize rats. Channels were expressed sep. in frog oocytes and studied using 2-electrode voltage clamp techniques at drug concentrations up to 10 mM. Normalized current effects were fit to Hill equations. Mint compounds were formulated in a lipid emulsion and administered IV to rats. When unresponsive to the tail clamp, rats were exsanguinated, and plasma drug concentrations were measured. Both mint compounds caused concentration-dependent inhibition of all channels except for Me salicylate which inhibited GABAA receptors at low concentrations and potentiated at high concentrations Plasma drug concentrations in anesthetized rats were 7.9 mM for L-carvone and 2.7 mM for Me salicylate. This corresponded to ≥53% NMDA receptor inhibition and ≥78% Nav1.2 channel inhibition by both compounds and 30% potentiation of GABAA receptors by Me salicylate. Conclusion: L-Carvone and Me salicylate allosterically modulate cell receptor targets important to mol. actions of conventional anesthetics at concentrations that also induce general anesthesia in rats. The experimental part of the paper was very detailed, including the reaction process of Methyl Salicylate(cas: 119-36-8Quality Control of Methyl Salicylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lu, Mengqi’s team published research in Physiologia Plantarum in 2021 | CAS: 119-36-8

Lu, Mengqi; Zhou, Junqin; Liu, Yiyao; Yang, Jin; Tan, Xiaofeng published their research in Physiologia Plantarum in 2021. The article was titled 《CoNPR1 and CoNPR3.1 are involved in SA- and MeSA- mediated growth of the pollen tube in Camellia oleifera》.Recommanded Product: 119-36-8 The article contains the following contents:

Salicylic acid (SA) is a plant hormone involved in a series of growth, development, and stress responses in plants. Nonexpressor of pathogenesis-related genes 1 (NPR1) is the core regulatory gene in the process of SA-mediated systemic acquired resistance (SAR). Whether NPR1 is involved in pollen tube growth mediated by SA and its derivative MeSA (Me salicylate) remains to be explored. Here, we found that the contents of endogenous SA and MeSA in self- or cross-pollinated pistils changed significantly, and exogenous SA and MeSA significantly promoted pollen germination and pollen tube elongation of Camellia oleifera at lower concentrations CoNPR1, CoNPR3.1, CoNPR3.2, and CoNPR5 were identified, and they were all located in the nucleus. A high level of consistency was observed across the phylogenetic relationships, gene structures, and functional domains, indicating a clear division of function, as observed in other species. The expression levels of CoNPR1, CoNPR3.1, CoNPR3.2, and CoNPR5 in self- and cross-pollinated pistils had certain regularity. Furthermore, they exhibited tissue-specific expression pattern. CoNPR1 and CoNPR3.1 were expressed in pollen tubes, whose expression was regulated by SA or MeSA, and their expression patterns were basically consistent with the trend of pollen germination. These results indicate that SA and MeSA are involved in the pollen tube growth of C. oleifera, and CoNPRs may play an important role therein. In the part of experimental materials, we found many familiar compounds, such as Methyl Salicylate(cas: 119-36-8Recommanded Product: 119-36-8)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Niemczynowicz, Agnieszka’s team published research in PLoS One in 2020 | CAS: 119-36-8

《Spectroscopic and theoretical studies of fluorescence effects induced by the ESIPT process in a new derivative 2-Hydroxy-N-(2-phenylethyl)benzamide – Study on the effects of pH and medium polarity changes》 was written by Niemczynowicz, Agnieszka; Budziak, Iwona; Kulesza, Slawomir; Gorecki, Andrzej; Makowski, Marcin; Karcz, Dariusz; Starzak, Karolina; Gladyszewska, Bozena; Podlesny, Janusz; Piotrowicz-Cieslak, Agnieszka I.; Matwijczuk, Arkadiusz. Application In Synthesis of Methyl Salicylate And the article was included in PLoS One in 2020. The article conveys some information:

The results of the studies conducted with the use of stationary and time-resolved fluorescence spectroscopy for the new derivative 2-hydroxy-N-(2-phenylethyl)benzamide (SAL-3) in aqueous solutions with various concentrations of hydrogen ions as well as in solvent mixtures (i.e. media with changing polarity/polarizability) was reported. For the compound selected for the study placed in aqueous solutions with varying concentration of hydrogen ions, the fluorescence emission spectra revealed a single emission band within most of the pH range, however, at low pH (less than 3) a significant broadening (noticeable effect of dual fluorescence) and shifting of the band was observed Whereas, for water and polar (protic) solvents, we observed a very interesting phenomenon of dual fluorescence never before reported for this particular group of analogs (with the specific substituent system). Based on the results of the experiments, it was observed that the presented effects may be related both with conformational effects (related to the possible positioning of the-OH group on the side of the carbonyl system, which facilitates the possibility of proton transfer) as well as, most importantly, the effects of excited state intramol. proton transfer (ESIPT) related in this case with the necessary (new/previously unobserved in published literature) presence of ionic and non-ionic forms of the compound. Both the conducted quantum-mech. time-dependent d. functional theory calculations and excited state dipole moment change calculations for the analyzed mol. in solvents with varying pH confirmed the association between the observed fluorescence phenomena and the two aforementioned effects. In addition to this study using Methyl Salicylate, there are many other studies that have used Methyl Salicylate(cas: 119-36-8Application In Synthesis of Methyl Salicylate) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Collins, Samuel’s team published research in Scientific Reports in 2020 | CAS: 119-36-8

ãHuman volunteer study of the decontamination of chemically contaminated hair and the consequences for systemic exposureã?was written by Collins, Samuel; James, Thomas; Southworth, Felicity; Davidson, Louise; Williams, Natalie; Orchard, Emily; Marczylo, Tim; Amlot, Richard. Reference of Methyl Salicylate And the article was included in Scientific Reports in 2020. The article conveys some information:

The decontamination of exposed persons is a priority following the release of toxic chems. Efficacious decontamination reduces the risk of harm to those directly affected and prevents the uncontrolled spread of contamination. Human studies examining the effectiveness of emergency decontamination procedures have primarily focused on decontaminating skin, with few examining the decontamination of hair and scalp. We report the outcome of two studies designed to evaluate the efficacy of current United Kingdom (UK) improvised, interim and specialist mass casualty decontamination protocols when conducted in sequence. Decontamination efficacy was evaluated using two chem. simulants, Me salicylate (MeS) and benzyl salicylate (BeS) applied to and recovered from the hair of volunteers. Twenty-four-hour urinary MeS and BeS were measured as a surrogate for systemic bioavailability. Current UK decontamination methods performed in sequence were partially effective at removing MeS and BeS from hair and underlying scalp. BeS and MeS levels in urine indicated that decontamination had no significant effect on systemic exposure raising important considerations with respect to the speed of decontamination. The decontamination of hair may therefore be challenging for first responders, requiring careful management of exposed persons following decontamination. Further work to extend these studies is required with a broader range of chem. simulants, a larger group of volunteers and at different intervention times. The experimental process involved the reaction of Methyl Salicylate(cas: 119-36-8Reference of Methyl Salicylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Collins, Samuel’s team published research in Scientific Reports in 2021 | CAS: 119-36-8

Collins, Samuel; Williams, Natalie; Southworth, Felicity; James, Thomas; Davidson, Louise; Orchard, Emily; Marczylo, Tim; Amlot, Richard published an article in 2021. The article was titled ãEvaluating the impact of decontamination interventions performed in sequence for mass casualty chemical incidentsã? and you may find the article in Scientific Reports.Safety of Methyl Salicylate The information in the text is summarized as follows:

The Initial Operational Response (IOR) to chem. incidents is a suite of rapid strategies including evacuation, disrobe and improvised and interim decontamination. IOR and Specialist Operational Response (SOR) decontamination protocols involving mass decontamination units would be conducted in sequence by UK emergency services following a chem. incident, to allow for safe onward transfer of casualties. As part of a series of human volunteer studies, we examined for the first time, the effectiveness of UK IOR and SOR decontamination procedures alone and in sequence. Specifically, we evaluated the addnl. contribution of SOR, when following improvised and interim decontamination. Two simulants, Me salicylate (MeS) with vegetable oil and benzyl salicylate (BeS), were applied to participantsâ?skin. Participants underwent improvised dry, improvised wet, interim wet, specialist decontamination and a no decontamination control. Skin anal. and UV photog. indicated significantly lower levels of both simulants remaining following decontamination compared to controls. There were no significant differences in MeS levels recovered between decontamination conditions. Anal. of BeS, a more persistent simulant than MeS, showed that recovery from skin was significantly reduced following combined IOR with SOR than IOR alone. These results show modest addnl. benefits of decontamination interventions conducted in sequence, particularly for persistent chems., supporting current UK operational procedures.Methyl Salicylate(cas: 119-36-8Safety of Methyl Salicylate) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics