Category: 119-36-8

《Acute kidney injury among salicylate intoxication hospitalisations in the United States》 was written by Thongprayoon, Charat; Petnak, Tananchai; Kaewput, Wisit; Qureshi, Fawad; Mao, Michael A.; Pivovarova, Aleksandra I.; Boonpheng, Boonphiphop; Bathini, Tarun; Vallabhajosyula, Saraschandra; Medaura, Juan; Cheungpasitporn, Wisit. Name: Methyl Salicylate And the article was included in International Journal of Clinical Practice in 2021. The article conveys some information:

This study aimed to evaluate the risk factors and the association of acute kidney injury (AKI) with outcomes, and resource utilization in patients hospitalised because of salicylate intoxication in the United States. Hospitalised patients with a primary diagnosis of salicylate intoxication from 2003 to 2014 were identified in the National Inpatient Sample (NIS) database. End-stage kidney disease patients were excluded. The occurrence of AKI was identified using hospital diagnosis code. Clin. characteristics, in-hospital treatment, outcomes and resource utilization were compared between patients with and without AKI. A total of 13 787 eligible hospital admissions were included in the anal. AKI occurred in 1279 (9.3%) admissions. Older age, male sex, more recent year of hospitalisation, anemia, hypertension, congestive heart failure, chronic kidney disease, volume depletion, sepsis and ventricular arrhythmia/cardiac arrest were significantly associated with increased risk of AKI, whereas Hispanic race was associated with decreased risk. AKI was significantly associated with increased risk of organ failure, and in-hospital mortality. In addition, the need for ventilation support, blood component transfusion, renal replacement therapy, length of hospital stay and hospitalisation cost were higher in AKI patients. Approx. one tenth of salicylate intoxication patients developed AKI during hospitalisation. AKI was associated with higher morbidity, mortality and resource utilizations. In the part of experimental materials, we found many familiar compounds, such as Methyl Salicylate(cas: 119-36-8Name: Methyl Salicylate)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Name: Methyl Salicylate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 119-36-8In 2020 ,《Diffusion modeling of percutaneous absorption kinetics. Predicting urinary excretion from in vitro skin permeation tests (IVPT) for an infinite dose》 was published in European Journal of Pharmaceutics and Biopharmaceutics. The article was written by Liu, Xin; Yousef, Shereen; Anissimov, Yuri G.; van der Hoek, John; Tsakalozou, Eleftheria; Ni, Zhanglin; Grice, Jeffrey E.; Roberts, Michael S.. The article contains the following contents:

In this work, we developed a number of generalised skin diffusion based pharmacokinetic models to relate published in vivo urinary excretion data to matching exptl. generated in vitro human skin permeation test (IVPT) data for a series of topically applied salicylate esters. A simplified linear in vivo model was found to inadequately describe the time course of urinary excretion over the entire sampling period. We represented the skin barrier as both a one layer (stratum corneum) and a two-layer (stratum corneum with viable epidermis) diffusion model and convoluted their Laplace solutions with that for a single exponential disposition phase to describe the urinary excretion profiles in the Laplace domain. We also derived asymptotic approximations for the model and estimated the conditions under which they could be used. We then sought to develop in vitro – in vivo relationships (IVIVR) for topically applied Me, Et and glycol salicylates using our exptl. IVPT data and the literature urinary excretion data. Good linear IVIVRs for Et and glycol salicylates were obtained, but the IVIVR for Me salicylate was poor, perhaps because of topical stimulation of local skin blood flow by Me salicylate. The ratio of the hydrated to dehydrated skin permeation for all salicylate esters was the same in both the IVPT and in vivo studies. A diffusion based one compartment pharmacokinetic model was also developed to describe the urinary excretion of solutes after removal of topical products and to compare the Me salicylate skin permeation for five different body sites. The work presented here is consistent with the development of skin IVIVRs, but suggests that different skin conditions, application sites and local skin effects may affect model predictions. In the experiment, the researchers used Methyl Salicylate(cas: 119-36-8Application of 119-36-8)

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Application of 119-36-8

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,International Journal for Ion Mobility Spectrometry included an article by Ahrens, Andre; Hitzemann, Moritz; Zimmermann, Stefan. Application of 119-36-8. The article was titled 《Miniaturized high-performance drift tube ion mobility spectrometer》. The information in the text is summarized as follows:

Developing powerful hand-held drift tube ion mobility spectrometers (IMS) requires small, lightweight drift tubes with high anal. performance. In this work, we present an easy-to-manufacture, miniaturized drift tube ion mobility spectrometer, which is manufactured from polyether ether ketone, stainless steel foils and printed circuit boards. It is possible to operate the drift tube IMS with a radioactive 3H ionization source or a non-radioactive X-ray ionization source with 3 kV acceleration voltage. The drift tube design provides high resolving power of Rp = 63 at a drift length of just 40 mm, 15 mm × 15 mm in cross-section (outer dimensions) and a drift voltage of 2.5 kV. The limits of detection for less than one second of averaging are 40 pptv for dimethyl-methylphosphonate and 30 pptv for Me salicylate. For demonstration, the miniaturized drift tube IMS is integrated into a stand-alone battery-powered mobile device, including a closed gas-loop, high performance driver electronics and wireless data transmission. In a proof-of-concept study, this device was tested in an international field evaluation exercise to detect the release of a volatile, hazardous substance inside a large entry hall. In the experimental materials used by the author, we found Methyl Salicylate(cas: 119-36-8Application of 119-36-8)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Application of 119-36-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system》 were Gershkovich, Miron Mikhailowitsch; Gross, Victoria Elisabeth; Kaiser, Anette; Proemel, Simone. And the article was published in Cell Communication and Signaling in 2019. Safety of Methyl Salicylate The author mentioned the following in the article:

The neuropeptide Y system affects various processes, among others food intake, and is frequently discussed in the context of targeting obesity. Studies in model organisms are indispensable to enable mol. studies in a physiol. context. Although the NPY system is evolutionarily conserved in all bilaterians, in the widely used model Caenorhabditis elegans there is controversy on the existence of NPY orthologous mols. While the FMRFamide-like peptide (FLP)/Neuropeptide receptor-Resemblance (NPR) system in the nematode was initially suggested to be orthologous to the mammalian NPY system, later global phylogenetic studies indicate that FLP/NPR is protostome-specific. We performed a comprehensive pharmacol. study of the FLP/NPR system in transfected cells in vitro, and tested for functional substitution in C. elegans knockout strains. Further, we phenotypically compared different flp loss-of-function strains. Differences between groups were compared by ANOVA and post-hoc testing (Dunnett, Bonferroni). Our pharmacol. anal. of the FLP/NPR system including formerly functionally uncharacterized NPY-like peptides from C. elegans demonstrates that G protein-coupling and ligand requirements for receptor activation are similar to the human NPY system. In vitro and in vivo analyses show cross-reactivity of NPY with the FLP/NPR system manifesting in the ability of the human GPCRs to functionally substitute FLP/NPR signaling in vivo. The high pharmacol./functional similarities enabled us to identify C. elegans FLP-14 as a key mol. in avoidance behavior. Our data demonstrate the pharmacol. and functional similarities of human NPY and C. elegans NPR systems. This adds a novel perspective to current phylogenetic reconstructions of the neuropeptide Y system. NPY and NPR receptors are pharmacol. so similar that the human receptors can functionally compensate for the C. elegans ones, suggesting orthologous relationships. This is also underlined by the presence of NPY-like peptides and parallels in peptide requirements for receptor activation. Further, the results presented here highlight the potential of this knowledge for physiol. as well as mol. studies on neuropeptide GPCRs such as the NPY system in the future. After reading the article, we found that the author used Methyl Salicylate(cas: 119-36-8Safety of Methyl Salicylate)

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Safety of Methyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Compact and Sensitive Dual Drift Tube Ion Mobility Spectrometer with a New Dual Field Switching Ion Shutter for Simultaneous Detection of Both Ion Polarities》 was published in Analytical Chemistry (Washington, DC, United States) in 2020. These research results belong to Lippmann, Martin; Kirk, Ansgar T.; Hitzemann, Moritz; Zimmermann, Stefan. Recommanded Product: Methyl Salicylate The article mentions the following:

Ion mobility spectrometers (IMS) with field switching ion shutters are an excellent choice for trace gas detection, being extremely sensitive while having fast response times. However, as different target mols. may form pos., neg., or even ions of both polarities, it is beneficial to simultaneously detect both ion polarities. Here, we present a dual drift tube IMS with a new dual field switching ion shutter for gating both ion polarities and an X-ray ionization source in orthogonal configuration. The dual field switching ion shutter allows significantly improved ion gating and ion accumulation due to improved shielding of the ionization region from the drift field. Equipped with two 75 mm long high-performance drift tubes, the dual IMS reaches high resolving power of R = 90 with detection limits in the lower pptv range for different ketones, chlorinated hydrocarbons and Me salicylate that forms ions in both polarities. The experimental process involved the reaction of Methyl Salicylate(cas: 119-36-8Recommanded Product: Methyl Salicylate)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Recommanded Product: Methyl Salicylate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Exogenous methyl salicylate alleviates senescent spotting by enhancing the activity of antioxidative ascorbate-glutathione cycle in harvested ‘Sucrier’ bananas》 was written by Chotikakham, Sirawich; Faiyue, Bualuang; Uthaibutra, Jamnong; Saengnil, Kobkiat. Electric Literature of C8H8O3 And the article was included in Scientia Horticulturae (Amsterdam, Netherlands) in 2020. The article conveys some information:

Senescent peel spotting, a physiol. disorder, develops during the latter stage of ripening which coincides with the best eating quality of ‘Sucrier’ banana fruit. It is a major constraint for banana growers and traders. The aims of this study were to evaluate the regulatory roles of Me salicylate (MeSA) on the senescent spotting and the activity of antioxidative ascorbate glutathione (ASA-GSH) cycle in ‘Sucrier’ banana during storage. ‘Sucrier’ bananas (ripening stage 3-4) were immersed in 0 (control) and 2 mM MeSA for 30 min, then air dried and stored at 25 ± 1°C for 6 d. After treatment, peel spotting, reactive oxygen species (ROS) production (hydrogen peroxide and hydroxyl radical contents), oxidative membrane damage (malondialdehyde and protein carbonyl contents and electrolyte leakage), enzymic and non-enzymic components of ASA-GSH cycle were determined It was shown that the symptoms of peel spotting in the control group was observed on day 2 and the severity increased continuously throughout storage. The occurrence of peel spotting coincided with the marked increase in the ROS production and oxidative membrane damage. The activities of ASA-GSH cycle including ascorbate peroxidase, dehydroascorbate reductase, monodehydroascorbate reductase and glutathione reductase activities as well as ascorbate (ASA) and reduced glutathione (GSH) contents declined with an increase in the severity of peel spotting. However, MeSA treatment caused an overall increase in the activities of enzymic and non-enzymic antioxidants as well as ASA/dehydroascorbate and GSH/oxidized glutathione ratios for up to 5-6 d of storage. The increased activity of ASA-GSH cycle was also associated with the decreases in ROS levels, oxidative membrane damage and senescent spotting development, indicating that MeSA treatment could reduce senescent spotting of ‘Sucrier’ bananas during storage by enhancing the activity of ASA-GSH cycle leading to the induction of antioxidant defense system to overcome ROS production, oxidative damage and fruit senescence.Methyl Salicylate(cas: 119-36-8Electric Literature of C8H8O3) was used in this study.

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Electric Literature of C8H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Chakraborty, Poulami; Dastidar, Parthasarathi. Reference of Methyl Salicylate. The article was titled 《An easy access to topical gels of an anti-cancer prodrug (5-fluorouracil acetic acid) for self-drug-delivery applications》. The information in the text is summarized as follows:

An easy access to topical gels (both hydro- and organogels) derived from an anti-cancer prodrug namely 5-fluorouracil acetic acid (5-FuA) achieved by exploiting a simple salt formation strategy is reported for the first time. Nearly 85% of the salts synthesized were gelators. Single crystal structures of some of the gelator salts revealed an intriguing hydrogen bonding network including double stranded 1D chains stabilized through uracil-uracil complementary interactions and the crystal structures of the gelator salts corroborated well with the hypothesis based on which the gelators were designed. Studies indicated that both the hydrogel and the Me salicylate gel of the gelator salt FuA-15 were suitable for self-drug-delivery application. In the experimental materials used by the author, we found Methyl Salicylate(cas: 119-36-8Reference of Methyl Salicylate)

Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Reference of Methyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Chitosan-based films containing nanoemulsions of methyl salicylate: Formulation development, physical-chemical and in vitro drug release characterization》 was written by Silva, Talita Nascimento da; Reynaud, Franceline; Picciani, Paulo Henrique de Souza; de Holanda e Silva, Kattya Gyselle; Barradas, Thais Nogueira. Name: Methyl Salicylate And the article was included in International Journal of Biological Macromolecules in 2020. The article conveys some information:

Transdermal patches for analgesic purposes are widely used, however, their occlusive characteristics can often cause allergic reactions, irritating contact dermatitis, and allergic contact dermatitis upon extended use. Chitosan is a natural pos. charged bioadhesive polysaccharide with several biol. properties, being promising templates for sustained and controlled topical or transdermal drug delivery. Me salicylate (MS) is a non-steroidal topical anti-inflammatory drug (NSAID). MS is a lipophilic oily drug commonly found in transdermal patches, being difficult to incorporate into hydrophilic formulations such as Chitosan-based films. Thus, MS is a good candidate to be encapsulated into nanoemulsions (NE). This work reports the formulation development, phys.-chem. characterization, and in vitro drug release of NE-loaded Chitosan films formulated with MS, as a novel substitute for transdermal analgesic patches. MS was encapsulated into NE, which were prepared by ultrasonication and presented 29.3 nm ± 0.1 and PdI 0.167 ± 0.005. The incorporation of MS into NE prevented phase separation and provided a homogeneous phys. blending formulation, as confirmed by FTIR, TGA. NE-loaded films provided high drug incorporation in the films 94.08% ± 6.63%, and a smaller crystallinity degree in comparison with phys. mixture films, suggesting a plasticizing effect of nano-sized droplets. Besides, mean weight, thickness, and moisture content were increased in NE-loaded films in comparison with chitosan-based control films. In vitro drug release from NE-loaded films was significantly higher than for phys. mixture films, following Weibull and Korsmeyer-Peppas release kinetics models. The results suggest that NE-loaded chitosan film can increase the drug loading capacity of oil drugs and successfully control in vitro release, constituting a novel approach for transdermal drug delivery of NSAIDs. In the experiment, the researchers used Methyl Salicylate(cas: 119-36-8Name: Methyl Salicylate)

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Name: Methyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Category: esters-buliding-blocksIn 2021 ,《Identification of Novel Simulants for Toxic Industrial Chemicals and Chemical Warfare Agents for Human Decontamination Studies: A Systematic Review and Categorisation of Physicochemical Characteristics》 appeared in International Journal of Environmental Research and Public Health. The author of the article were James, Thomas; Collins, Samuel; Marczylo, Tim. The article conveys some information:

A review. Chem. simulants have long been used in human trials of mass decontamination to determine the efficacy of decontamination interventions against more toxic agents. Until now, reliance has mostly been on individual chems. as surrogates to specific agents (e.g., Me salicylate for sulfur mustard). A literature review was conducted to identify chems. that had been previously tested on human volunteers and that represent diverse physicochem. characteristics in order to create a repository for chem. simulants. Of the 171 unique chems. identified, 78 were discounted for the risk they could pose to human volunteers, 39 were deemed suitable for use, and a further 54 were considered to be possible simulants but would require further research. Suitable simulants included both solid and liquid chems. spanning a wide range of physicochem. properties including mol. weight, octanol/water partition coefficient, vapor pressure, and solubility This review identifies an array of potential simulants suitable for use in human volunteer decontamination studies and is of relevance to future studies on systemic absorption and surface decontamination. After reading the article, we found that the author used Methyl Salicylate(cas: 119-36-8Category: esters-buliding-blocks)

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Optimisation and validation of a GC-MS/MS method for the analysis of methyl salicylate in hair and skin samples for use in human-volunteer decontamination studies》 were James, Thomas; Collins, Samuel; Amlot, Richard; Marczylo, Tim. And the article was published in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2019. Computed Properties of C8H8O3 The author mentioned the following in the article:

Me salicylate has a long history of use as a chem. warfare agent simulant for volatile lipophilic compounds such as sulfur mustard. An improved isotope dilution GC-MS/MS method was developed, optimized and validated for the anal. of Me salicylate in human skin and hair samples, for use in emergency decontamination volunteer studies. Following derivatization, quantification was measured on a triple quadrupole mass spectrometer, set to EI mode and conducting multiple reaction monitoring of target ions. The mass transitions were 209→179 and 213→161 for quantitation of Me salicylate and Me salicylate D4, resp. whereas qualifier ion transitions used to verify identity were 209→169 and 213→89. The method achieved excellent coefficient of determination (R2 >0.9968 to 0.9999) over the range of 0.5-5000 ng/mL and the LOD and LOQ were 0.05 ng/mL and 0.5 ng/mL. The method was further validated for accuracy (intra-day and inter-day average 100.28% to 102.03% and 99.48% to 102.33%, resp.) and precision (intra-day RSD 1.43% to 2.35%, inter-day RSD 1.91% to 2.97%) at three concentrations (25, 250 and 2500 ng/mL). The validated method was successfully used to identify Me salicylate in samples of human skin generated during volunteer studies of emergency decontamination systems and in hair of staff conducting these studies.Methyl Salicylate(cas: 119-36-8Computed Properties of C8H8O3) was used in this study.

Methyl Salicylate(cas: 119-36-8) is a natural herbivore-induced plant volatile. It is a naturally occurring product in trees, legumes, exotic plants, vegetables, berries, and the primary constituent of the oil of wintergreen.Methyl Salicylate is produced from salicylic acid.Computed Properties of C8H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics