Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1187318-53-1, name is 3-Bromo-5-fluoro-2-methyl-benzoic acid methyl ester, A new synthetic method of this compound is introduced below., name: 3-Bromo-5-fluoro-2-methyl-benzoic acid methyl ester
To a solution of methyl 3-bromo-5-fluoro-2-methylbenzoate (3.38 g, 13.7 mmol) in CCl4 (40 mL) at RT was added NBS (3.18 g, 17.9 mmol) and the reaction flask was purged with N2. After heating at 85 C for 5 m, AIBN (1.18 g, 6.87 mmol) was added, and the mixture was heated at 85 C overnight. The mixture was concentrated, diluted with H2O, and extracted with EtOAc. The organic phase was dried over Na2S04, filtered, and concentrated to give the crude product, which was purified using silica gel eluting with EtOAc in petroleum ether (0% to 1%) to give methyl 3-bromo-2-(bromomethyl)-5-fluorobenzoate (3.3 g, 74% yield) as an oil.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BIOTHERYX, INC.; CHAN, Kyle W.H.; CHOURASIA, Aparajita Hoskote; FUNG, Leah; MERCURIO, Frank; SULLIVAN, Robert; (0 pag.)WO2019/173224; (2019); A1;,
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