Category: 118-55-8

Torregrosa-Chinillach, Alejandro; Moragues, Adrien; Perez-Furundarena, Haritz; Chinchilla, Rafael; Gomez-Bengoa, Enrique; Guillena, Gabriela published an article in 2018, the title of the article was Enantioselective michael addition of aldehydes to maleimides organocatalyzed by a chiral primary amine-salicylamide.Computed Properties of 118-55-8 And the article contains the following content:

A primary amine-salicylamide derived from chiral trans-cyclohexane-1,2-diamine was used as an organocatalyst for the enantioselective conjugate addition of aldehydes, mainly α,α-disubstituted to N-substituted maleimides. The reaction was performed in toluene as a solvent at room temperature The corresponding enantioenriched succinimides I (R1 = Me; R2 = Me, H; R1, R2 = (CH2)4, (CH2)5; R3 = C6H5, 4-MeC6H4, 4-MeOC6H4, etc.) were obtained with high yields and enantioselectivities up to 94%. Theor. calculations were used to justify the stereoinduction. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Computed Properties of 118-55-8

The Article related to succinimide enantioselective preparation primary amine salicylamide catalyst, aldehyde maleimide michael addition, michael addition, aldehydes, asymmetric synthesis, maleimides, organocatalysis and other aspects.Computed Properties of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2022, Liang, Liyuan; Chen, Hongyan published an article.Safety of Phenyl Salicylate The title of the article was Development and characterization of biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film modified by phenyl salicylate. And the article contained the following:

The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and Ph salicylate as the UV absorbent and antibacterial agent. Polylactic acid-cellulose acetate-Ph salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm). These results indicate that the UV shielding performance of the composite films could be significantly improve by addition of Ph salicylate. Moreover, the addition of 20% Ph salicylate could improve the steam resistance, mech. properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli. The composite films could reduce the decay rate of fresh lilies and extend their storage time. The degradation characteristics of the films were explored in the natural environment and the laboratory level, which provided application prospect for the development of degradable food packaging materials with anti-UV and anti-bacteria effect. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Safety of Phenyl Salicylate

The Article related to polylactic acid cellulose acetate film phenyl salicylate antiuv antibacterial, antibacterial activity, cellulose acetate, composite film, phenyl salicylate, polylactic acid, ultraviolet resistance and other aspects.Safety of Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 15, 2020, Li, Ke; Jin, Yan; Jung, Dasom; Park, Keunbae; Kim, Hireem; Lee, Jeongmi published an article.Recommanded Product: 118-55-8 The title of the article was In situ formation of thymol-based hydrophobic deep eutectic solvents: Application to antibiotics analysis in surface water based on liquid-liquid microextraction followed by liquid chromatography. And the article contained the following:

A simple and ecofriendly sample preparation method was developed for quantifying fluoroquinolone (FQ) antibiotics in surface water. Seventeen combinations of monoterpenes (menthol, thymol, and camphor), fatty acids (heptanoic, octanoic, nonanoic, and decanoic acids), and a benzoate ester (salol) were utilized for the in situ formation of hydrophobic deep eutectic solvents (hDESs) for liquid-liquid microextraction (LLME). The hDES comprising thymol and heptanoic acid (HA) exhibited the highest extraction efficiency for ofloxacin, norfloxacin, ciprofloxacin, and enrofloxacin. Optimization via the one-variable-at-a-time strategy revealed that a 2:1 ratio of thymol to HA yielded the highest efficiency for antibiotic extraction at pH 4-7. Further, response surface methodol.-based optimization suggested that the optimal extraction conditions involved the use of appropriate amounts of thymol and HA to generate 100μL of hDES in 10 mL of aqueous sample with incubation at 52°C for 5 min, followed by automated shaking for 1 min. The collected hDES phase was diluted and subjected to liquid chromatog.-UV detection anal. The established method based on in situ formation of hDES coupled with shaker-assisted LLME (in situ hDES-SA-LLME) was validated. The method was specific and showed good linearity in the 15-3000 ng mL-1 concentration range (r2 ≥ 0.9997), with a limit of detection of 3.0 ng mL-1, limit of quantification of 9.0 ng mL-1, accuracy of 84.1-113.65%, and intra-day and inter-day precision of ≤7.78% RSD and ≤7.91% RSD, resp. The method was successfully applied to three different types of real surface water samples. Without toxic volatile organic solvents, the developed method allows for safe and rapid, yet reliable, anal. of FQ antibiotics. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Recommanded Product: 118-55-8

The Article related to fluoroquinolone antibiotic liquid microextraction water deep eutectic solvent, antibiotics, hydrophobic deep eutectic solvents, in situ formation, liquid-liquid microextraction, surface water sample and other aspects.Recommanded Product: 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rashed, Nurnobi Md.; Siddiki, S. M. A. Hakim; Touchy, Abeda Sultana; Jamil, A. R. Md.; Poly, Sharmin Sultana; Toyao, Takashi; Maeno, Zen; Shimizu, Ken-ichi published an article in 2019, the title of the article was Direct Phenolysis Reactions of Unactivated Amides into Phenolic Esters Promoted by a Heterogeneous CeO2 Catalyst.Recommanded Product: Phenyl Salicylate And the article contains the following content:

The direct catalytic esterification of amides that leads to the construction of C-O bonds through the cleavage of amide C-N bonds is a highly attractive strategy in organic synthesis. While aliphatic and aromatic alcs. can be readily used for the alcoholysis of activated and unactivated amides, the introduction of phenols is more challenging due to their lower nucleophilicity in the phenolysis of unactivated amides. Herein, phenols can be used for the phenolysis of unactivated amides into the corresponding phenolic esters using a simple heterogenous catalytic system based on CeO2 under additive-free reaction conditions was demonstrated. The method tolerates a broad variety of functional groups (>50 examples) in the substrates. Results of kinetic studies afforded mechanistic insights into the principles governing this reaction, suggesting that the cooperative effects of the acid-base functions of catalysts would be of paramount importance for the efficient progression of the C-N bond breaking process, and consequently, CeO2 showed the best catalytic performance among the catalysts explored. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Recommanded Product: Phenyl Salicylate

The Article related to phenolic ester preparation solvent free, amide aliphatic aromatic alc direct phenolysis ceo2 catalyst, acid-base cooperation, heterogeneous catalysts, phenolic esters, phenolysis, unactivated amides and other aspects.Recommanded Product: Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 1, 2018, Fagge, Ibrahim Isah; Khalid, Khalisanni; Noh, Muhammad Azri Mohd.; Yusof, Nor Saadah Muhammad; Zain, Sharifuddin Md.; Khan, Mohammad Niyaz published an article.Synthetic Route of 118-55-8 The title of the article was Study of cationic and nonionic mixed micelles with NaBr and 3,5-Cl2C6H3CO2Na by use of probe nucleophilic reaction of piperidine with ionized phenyl salicylate. And the article contained the following:

Behaviors of cationic and nonionic mixed micelles in the form of hexadecyltrimethylammonium bromide (HDABr) and hexadecyltrimethylammonium bromide-Polyethylene glycol hexadecyl ether (C16E20), in the presence of inert salts (NaBr and 3,5-dichlorosodium benzoate), by the use of reaction probe between Pp and ionized PhSH (Pp = piperidine and PhSH = Ph salicylate), has been reported in this work. The values of RXBr (RXBr denotes ion exchange constants obtained in the presence of micelles of different structural features) or KXBr (KXBr denotes ion exchange constants obtained in the presence of micelles of the same structural features) for 3,5- Cl2C6H3CO2- were almost the same at three different [HDABr]T (0.006, 0.010 and 0.015 M). The average value of RXBr or KXBr determined, in the presence of pure HDABr micelles, using semi empirical kinetic (SEK) method appeared to be almost 21/2-fold larger (RXBr or KXBr = 198) than that in the presence of mixed HDABr-C16E20 micelles (RXBr or KXBr = 78). Rheol. measurements indicated the existence of wormlike/twisted micelles and vesicle at 0.015 M pure HDABr, various [3,5- Cl2C6H3CO2Na], and 25 and 35°C whereas there were evidence of only spherical micelles in the presence of mixed HDABr-C16E20 ([HDABr]T = 0.015 M and [C16E20]T = 0.006 M) at both temperatures The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Synthetic Route of 118-55-8

The Article related to sodium bromide piperidine phenyl salicylate micelle probe nucleophilic reaction, hexadecyltrimethylammonium bromide, phenyl salicylate, piperidine, polyethylene glycol hexadecyl ether, vesicle, wormlike micelles and other aspects.Synthetic Route of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 29, 2019, Ohtsuki, Yuya; Sanoh, Seigo; Santoh, Masataka; Ejiri, Yoko; Ohta, Shigeru; Kotake, Yaichiro published an article.SDS of cas: 118-55-8 The title of the article was Inhibition of cytochrome P450 3A protein degradation and subsequent increase in enzymatic activity through p38 MAPK activation by acetaminophen and salicylate derivatives. And the article contained the following:

We previously reported that acetaminophen (APAP) caused accumulation of functional CYP3A protein via inhibition of CYP3A protein degradation through reduction of glycoprotein 78 (gp78), an E3 ligase of the ubiquitin proteasome system. Furthermore, N-acetyl-m-aminophenol, a regioisomer of APAP causes CYP3A protein accumulation, whereas p-acetamidobezoic acid, in which a hydroxy group of APAP was substituted for a carboxy group, did not lead to the same effects. In this study, we selected 32 compounds including a phenolic hydroxyl group such as APAP and explored the compounds that increased CYP3A enzyme activity to analyze their common mechanism. Four compounds, including salicylate, increased CYP3A enzyme activity and led to the accumulation of functional CYP3A protein similarly to APAP. APAP and salicylate activate p38 mitogen-activated protein kinase (p38 MAPK). gp78 is known to be phosphorylated by p38 MAPK; so, we investigated the relationship between p38 MAPK and CYP3A. APAP activated p38 MAPK, decreased gp78 protein expression, and subsequently induced CYP3A protein expression in a time-dependent manner. When SB203580, a p38 MAPK inhibitor, was co-administered with APAP, the inhibitory effects of APAP on CYP3A protein degradation were suppressed. In this study, we demonstrated the involvement of the p38 MAPK-gp78 pathway in suppressing CYP3A protein degradation by APAP. Salicylate derivatives may also suppress the CYP3A protein degradation The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).SDS of cas: 118-55-8

The Article related to cytochrome protein degradation enzymic activity mapk activation acetaminophen salicylate, acetaminophen, cytochrome p450 3a, glycoprotein 78, protein degradation, salicylate, p38 mitogen-activated protein kinase and other aspects.SDS of cas: 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 15, 2019, Wu, Ren-Jun; Ren, Tongtong; Gao, Jie-Yu; Wang, Li; Yu, Qilin; Yao, Zheng; Song, Guo-Qing; Ruan, Wei-Bin; Niu, Cong-Wei; Song, Fu-Hang; Zhang, Li-Xin; Li, Mingchun; Wang, Jian-Guo published an article.Formula: C13H10O3 The title of the article was Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase. And the article contained the following:

A novel synthesis of 68 ethoxysulfulron (ES) derivatives I [R1 = 2-NO2, 2-COOMe, 2-I(CH2)2O, etc.; R2 = Me, MeO, Cl, Br, I; R3 = Me, MeO] and evaluation of their inhibition constants (Ki) against C. albicans AHAS and cell based min. inhibitory concentration (MIC) values were discussed. The target compounds I [R1 = 2-COOEt; R2 = Me, MeO, Cl, Br, I; R3 = MeO] displayed stronger AHAS inhibitions than ES did. Compound I [R1 = 2-COOEt, R2 = MeO, R3 = MeO] had the best Ki of 6.7 nM against fungal AHAS and MIC values of 2.5 mg/L against Candida albicans and Candida parapsilosis after 72 h. A suitable nematode model was established here and the antifungal activity of compound I [R1 = 2-COOEt, R2 = MeO, R3 = MeO] was further evaluated in-vivo. A possible binding mode was simulated via mol. docking and a comparative field anal. (CoMFA) model was constructed to understand the structure-activity relationship. The current study had indicated that some ES derivatives should be considered as promising hits to develop antifungal drugs with novel biol. target. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Formula: C13H10O3

The Article related to phenyl pyrimidinylcarbamoylsulfamate preparation antifungal acetohydroxyacid synthase inhibition sar docking, acetohydroxyacid synthase, antifungal agents, enzyme inhibition, ethoxysulfuron derivative, nematode model and other aspects.Formula: C13H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Martinez-Guillen, Jose R.; Flores-Ferrandiz, Jesus; Gomez, Cecilia; Gomez-Bengoa, Enrique; Chinchilla, Rafael published an article in 2018, the title of the article was Asymmetric conjugate addition of α,α-disubstituted aldehydes to nitroalkenes organocatalyzed by chiral monosalicylamides from trans-cyclohexane-1,2-diamines.Name: Phenyl Salicylate And the article contains the following content:

Primary amine-salicylamides derived from chiral trans-cyclohexane-1,2-diamines are used as organocatalysts for the enantioselective conjugate addition of α,α-disubstituted aldehydes to arylated and heteroarylated nitroalkenes. The reaction is performed in the presence of 4-dimethylaminopyridine as an additive in dichloromethane as a solvent at room temperature The corresponding enantioenriched γ-nitroaldehydes are obtained with enantioselectivities up to 95%. Theor. calculations are used to justify the reasons of the stereoinduction. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Name: Phenyl Salicylate

The Article related to chiral monosalicylamides trans cyclohexane diamine asym conjugate dimethylaminopyridine additive, disubstituted aldehydes nitroalkenes organocatalyst dichloromethane enantioselectivity, michael addition, asymmetric synthesis, nitroalkenes, organocatalysis and other aspects.Name: Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 18, 2018, Wang, Xiuqin; Feng, Juanjuan; Tian, Yu; Luo, Chuannan; Sun, Min published an article.HPLC of Formula: 118-55-8 The title of the article was Co-Al bimetallic hydroxide nanocomposites coating for online in-tube solid-phase microextraction. And the article contained the following:

The Co-Al bimetallic hydroxide nanocomposites were synthesized and used as in-tube solid-phase microextraction coating. The nanocomposites-coated fibers were packed in a PEEK tube and tested for the extraction of eight polycyclic aromatic hydrocarbons (PAHs) coupled with high performance liquid chromatog. Several parameters affecting the PAHs extraction including the sampling volume, sampling flow rate, methanol content and desorption time were investigated. Under the optimized conditions, the extraction tube with nanocomposites coating exhibited remarkable extraction performance towards PAH targets. An online anal. method was achieved with the limits of detection less than 0.02 μg L-1 and the linearity in the range from 0.03 to 15 μg L-1. The recoveries of the method for two water samples with spiking levels of 1 and 10 μg L-1 ranged from 83 to 121%. Extraction repeatability and preparation repeatability were less than 4.0% and 10.9%, resp. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).HPLC of Formula: 118-55-8

The Article related to cobalt aluminum hydroxide coating microextraction polycyclic aromatic hydrocarbon water, co-al bimetallic hydroxide, high performance liquid chromatography, nanocomposites coating, online analysis, polycyclic aromatic hydrocarbons, solid-phase microextraction and other aspects.HPLC of Formula: 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 20, 2022, Nandi, Shantanu; Mondal, Shuvam; Jana, Ranjan published an article.Application In Synthesis of Phenyl Salicylate The title of the article was Chemo- and regioselective benzylic C(sp3)-H oxidation bridging the gap between hetero- and homogeneous copper catalysis. And the article contained the following:

An expedient synthesis of privileged seven-membered lactones, dibenzo[c,e]oxepin-5(7H)-one through a highly chemoselective benzylic C(sp3)-H activation was disclosed. Remarkably, the formation of widely explored six-membered lactone via C(sp2)-H activation was suppressed under the present conditions. The reaction proceeded smoothly on use of inexpensive metallic copper catalyst and di-tert-Bu peroxide (DTBP). Owing to the hazards of stoichiometric DTBP, further, a sustainable metallic copper/rose bengal dual catalytic system coupled with mol. oxygen replacing DTBP was developed. A 1,5-aryl migration through Smiles rearrangement was realized from the corresponding diaryl ether substrates instead of expected eight-membered lactones. The present methodol. was scalable, applied to the total synthesis of cytotoxic and neuroprotective natural product alterlactone. The catalyst was recyclable and the reaction could be performed in a copper bottle without any added catalyst. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Application In Synthesis of Phenyl Salicylate

The Article related to orthotolylbenzoic acid copper catalyst intramol benzylic oxidation cyclization, photosensitizer orthotolylbenzoic acid copper catalyst intramol benzylic oxidation cyclization, dibenzooxepinone chemoselective regioselective preparation, catalysis, chemistry, organic chemistry and other aspects.Application In Synthesis of Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics