Category: 118-55-8

On August 8, 2018, Serratore, Nicholas A.; Anderson, Constance B.; Frost, Grant B.; Hoang, Truong-Giang; Underwood, Steven J.; Gemmel, Philipp M.; Hardy, Melissa A.; Douglas, Christopher J. published an article.Safety of Phenyl Salicylate The title of the article was Integrating Metal-Catalyzed C-H and C-O Functionalization To Achieve Sterically Controlled Regioselectivity in Arene Acylation. And the article contained the following:

One major goal of organometallic chemists is the direct functionalization of the bonds most recurrent in organic mols.: C-H, C-C, C-O, and C-N. An even grander challenge is C-C bond formation when both precursors are of this category. Parallel to this is the synthetic goal of achieving reaction selectivity that contrasts with conventional methods. Electrophilic aromatic substitution (EAS) via Friedel-Crafts acylation is the most renowned method for the synthesis of aryl ketones, a common structural motif of many pharmaceuticals, agrochems., fragrances, dyes, and other commodity chems. However, an EAS synthetic strategy is only effective if the desired site for acylation is in accordance with the electronic-controlled regioselectivity of the reaction. Herein we report steric-controlled regioselective arene acylation with salicylate esters via iridium catalysis to access distinctly substituted benzophenones. Exptl. and computational data indicate a unique reaction mechanism that integrates C-O activation and C-H activation with a single iridium catalyst without an exogenous oxidant or base. We disclose an extensive exploration of the synthetic scope of both the arene and the ester components, culminating in the concise synthesis of the potent anticancer agent hydroxyphenstatin. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Safety of Phenyl Salicylate

The Article related to steric controlled regioselective arene acylation salicylate ester iridium catalyst, exptl computational data reaction mechanism benzophenone preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Safety of Phenyl Salicylate

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On December 4, 2020, Yang, Feiyan; Ding, Decai; Wang, Chuan published an article.Safety of Phenyl Salicylate The title of the article was Nickel-Catalyzed Directed Cross-Electrophile Coupling of Phenolic Esters with Alkyl Bromides. And the article contained the following:

Herein, we demonstrate the successful use of robust phenolic esters as an electrophilic acyl source in the reaction with diverse primary and secondary unactivated alkyl bromides. The cleavage of the relatively inert C-O bond is facilitated by the neighboring coordinating hydroxyl or sulfonamide moiety. By circumventing the use of pregenerated organometallics, this method allows efficient preparation of a variety of o-hydroxyl and tosyl-protected o-amino aryl ketones with high compatibility with a wide range of functionalities. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Safety of Phenyl Salicylate

The Article related to phenolic ester alkyl bromide nickel catalyst cross electrophile coupling, aryl ketone preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Safety of Phenyl Salicylate

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Neuroth, Gero; Klapper, Helmut published an article in 2020, the title of the article was The Generation of Growth Dislocations by Inclusions and Growth-Face Damages: An Experimental Study.Quality Control of Phenyl Salicylate And the article contains the following content:

The generation of growth dislocations in crystals by intentionally introduced foreign-particle inclusions and by mech. damaging (scratching) of the growth face is reported. The formation of dislocations is studied by in situ observation of the step pattern on the involved growth face by optical microscopy and-after growth-by X-ray diffraction topog. This is performed on three different growth faces of orthorhombic salol (C13H10O3, melting temperature Tm = 41.5°C) growing from the melt supercooled by 1-2°C. The development of the growth pattern after the closure of the inclusion by overgrowing layers and after the scratching is recorded by videos. Particularly instructive is the inclusion experiment on the fast-growing (100) face: immediately after the closure a big pyramid and fast step source appears, which dominates and sporadically overflows neighbored secondary step sources. In the sequel the big pyramid splits into a row of small hills which gradually diverge. This indicates that the associated dislocations fan out within the (010) plane of the crystal, as is confirmed by X-ray topog. The in situ scratching of the growth face triggers the immediate appearance and fast development of a complex hill structure associated with numerous dislocations. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Quality Control of Phenyl Salicylate

The Article related to growth dislocation inclusion face damage, Crystallography and Liquid Crystals: Crystallization and Recrystallization, Nucleation, Crystal Growth, Epitaxy, Nonepitaxial Film Deposition and other aspects.Quality Control of Phenyl Salicylate

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Liu, Tao; Hu, Jing; Yong, Li; Zhang, Gang; Zhang, Yi; Chen, Tong; Wang, Gongying published an article in 2019, the title of the article was Qualitative and quantitative analysis of the product and by-products from transesterification between phenol and dimethyl carbonate.Safety of Phenyl Salicylate And the article contains the following content:

Byproducts (Ph salicylate, Ph 4-hydroxybenzoate and xanthone) from transesterification between phenol and di-Me carbonate (DMC) were qual. analyzed by gas chromatog., mass spectrometry and a gas chromatog. method with directed injection for simultaneous quant. anal. of the product (DPC) and byproducts of the transesterification was established. Based on the results of qual. and quant. analyses, the mechanism of the byproducts generation was preliminarily deduced. The sample for quant. anal. was directly diluted in acetone, and related compounds were separated on an HP-5 capillary column and detected by a hydrogen flame ionization detector (FID). The product and byproducts were well separated, the correlation coefficients (r) within the concentration range of 1.0 μg/mL-100 μg/mL were ≥0.9997, the relative standard deviations were between 0.5% and 4.4%, spiked recoveries were between 91.5% and 105.6%, and detection limits were between 0.11 and 0.18 μg/mL. The established method was simple, rapid, accurate, sensitive and highly specific. It was suitable for simultaneous qual. and quant. analyses of the product and byproducts of transesterification between phenol and DMC. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Safety of Phenyl Salicylate

The Article related to phenol dimethyl carbonate transesterification, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Safety of Phenyl Salicylate

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Iyori, Yasuaki; Chatani, Naoto published an article in 2021, the title of the article was Nickel-catalyzed C-O/O-H Annulation of Salicylate Esters with Alkynes: Activation of C-O Bond in Esters.Category: esters-buliding-blocks And the article contains the following content:

The Ni-catalyzed C-O/O-H annulation of salicylate esters with alkynes, leaded to the production of chromones was reported. The key step in the reaction was the cleavage of an acyl C-O bond. The presence of a base was essential for the reaction to proceed. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Category: esters-buliding-blocks

The Article related to salicylate ester alkyne nickel catalyst regioselective cyclization, chromone preparation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Category: esters-buliding-blocks

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Huaimo; Liu, Song; Wang, Youyi; Yuan, Man; Zhang, Hong; Zhou, Hua; Xiao, Lianbo; Zheng, Changwu; Xu, Hongxi published an article in 2021, the title of the article was An efficient approach for the synthesis of 1,2-dihydroxanthones enabled by one-pot Claisen condensation/cyclization reactions.Synthetic Route of 118-55-8 And the article contains the following content:

In this report, a mild, efficient and green method for the synthesis of 1,2-dihydroxanthones (DHXs) I (R = H, Me, 3-methylbut-2-en-1-yl; R1 = H, Me; R2 = Me, Ph, 2,2,2-trifluoroethyl, but-3-en-1-yl, etc.; R3 = H, Me; R4 = H, F, OMe, Cl, Br, I; R5 = H, Me, OMe, Cl, CF3, F; R4R5 = -CH:CHCH:CH-; R6 = H, Cl, Me, prop-2-en-1-yl) and II (R7 = H, OMe) has been developed in one pot through Claisen condensation and O-cyclization under waste-induced relay catalysis with min. organic solvents. The byproduct (HMDS or NH3·H2O) of the first step turned out to be the promoter for the second step, which could efficiently proceed in aqueous media without the addition of other catalysts. The reactions using trifluoroethyl salicylates 2-OH-3-R6-4-R5-5-R4-6-R3C6HC(O)OCH2CF3 could be performed under mild conditions to ensure the generation of vulnerable DHXs I and II in high yields. The substrate scope is very broad regardless of the substituent type and its position on the structure. Specifically, the versatility of DHXs I (R = R1 = R3 = R4 = R5 = R6 = H; R2 = Me) was demonstrated by their conversion to xanthones I (R = 3-methylbut-2-en-1-yl; R1 = R3 = R4 = R5 = R6 = H; R2 = Me)/II (R7 = H) and other complex structures III/IV. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Synthetic Route of 118-55-8

The Article related to dihydroxanthone preparation green chem, cyclohexenone salicylate claisen condensation heterocyclization, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Synthetic Route of 118-55-8

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kusumoto, Sotaro; Kobayashi, Fumiya; Ohtani, Ryo; Zhang, Yingjie; Harrowfield, Jack; Kim, Yang; Hayami, Shinya; Nakamura, Masaaki published an article in 2018, the title of the article was Creating capsules with cubanes.Synthetic Route of 118-55-8 And the article contains the following content:

A sextuply linked capsule incorporating two Ni(II) cubane units is formed when Ni(II) salts are reacted with N-aminoalkyl salicylamidato ligands in a 4:3 ratio in methanol. With a short (propyl) alkyl substituent, addnl. chloride counterions are included in the cavity by occupation of one apex of each of the linked cubanes, while with a longer (pentyl) substituent, perchlorate and tetrafluoroborate anions are included, probably by H-bonding involving hydroxyl groups on the inner apexes of the cubanes, indicating that the cavity can be regarded as suited to binding of hydrophilic units despite the lipophilic character of its links. The dicubane capsules show ferromagnetic behavior typical of Ni(II) cubanes in general, with coupling constants dependent upon the nature of the salt-derived counteranions. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Synthetic Route of 118-55-8

The Article related to nickel aminoalkyl salicylamidato capsule cubane complex preparation crystal structure, thermal stability magnetic property nickel aminoalkyl salicylamidato capsule cubane and other aspects.Synthetic Route of 118-55-8

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Ester – an overview | ScienceDirect Topics

On August 7, 2020, Ai, Han-Jun; Zhang, Youcan; Zhao, Fengqian; Wu, Xiao-Feng published an article.Computed Properties of 118-55-8 The title of the article was Rhodium-Catalyzed Carbonylative Synthesis of Aryl Salicylates from Unactivated Phenols. And the article contained the following:

In the presence of RhCl3 and 1,2-bis(dicyclohexylphosphino)ethane (dcpe), phenols underwent carbonylative esterification reactions with CO mediated by TEMPO in 1.4-dioxane/toluene to yield aryl salicylates such as Ph salicylate. Under similar conditions, but using 1,3-bis(diphenylphosphino)propane as the ligand, di-Ph carbonate was obtained as the major product. The mechanism of the reaction was studied using the reactions of potential intermediates and using kinetic isotope effects. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Computed Properties of 118-55-8

The Article related to aryl hydroxybenzoate preparation, rhodium catalyst carbonylative esterification phenol, kinetic isotope effect mechanism rhodium catalyzed carbonylative esterification phenol and other aspects.Computed Properties of 118-55-8

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Abe, Haruka published an article in 2021, the title of the article was National standard and new reference material for specific heat capacity measurements.Category: esters-buliding-blocks And the article contains the following content:

Thermal anal. and calorimetry share a close relationship in the field of thermal research. With regards to the sp. heat capacity, researchers have been able to realize absolute measurement techniques by utilizing drop, conduction, and adiabatic methods that are used in calorimetry. Furthermore, it is possible to optimize differential scanning calorimetry, which is a comparative measurement technique for the sp. heat capacity used in thermal anal., by improving the absolute measurement techniques. At the National Metrol. Institute of Japan (NMIJ), we developed a new certified reference material (CRM) for comparatively measuring the sp. heat capacity, the single-crystalline silicon-NMIJ CRM 5806a, using a new type of cryogenic adiabatic calorimeter equipped with a pulse-tube refrigerator working at from 50 to 350 K. This CRM was produced in accordance with the quality specifications of NMIJ, and complies with the ISO/IEC 17025, ISO 17034, and ISO GUIDE 35 standards This paper reports on the procedure for fabricating this CRM and using it to perform sp. heat capacity measurements at low temperatures The sp. heat capacity was measured using a differential scanning calorimeter at from 280 to 340 K. NMIJ CRM 5806a was used to calibrate the heat flow. It was found that the uncertainty evaluation became easier because one factor of the uncertainty evaluation could be removed using the CRM. We show that the development of the CRM using the adiabatic calorimeter has led to an improvement in the sp. heat capacity measurement results obtained by the differential scanning calorimeter. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Category: esters-buliding-blocks

The Article related to specific heat capacity standard reference material, specific heat capacity, adiabatic calorimeter, differential scanning calorimeter, reference material, single-crystalline silicon and other aspects.Category: esters-buliding-blocks

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 10, 2020, Zhang, Kaige; Li, Shuangying; Wang, Yunhe; Fan, Jing; Zhu, Guifen published an article.Synthetic Route of 118-55-8 The title of the article was Air-assisted liquid-liquid microextraction based on solidification of floating deep eutectic solvent for the analysis of ultraviolet filters in water samples by high performance liquid chromatography with the aid of response surface methodology. And the article contained the following:

For this work, a novel air-assisted liquid-liquid microextraction based on solidification of floating deep eutectic solvent (AA-LLME-SFDES), coupled with a high performance liquid chromatog. (HPLC) method was developed for the detection of benzophenone and salicylate UV filters in water samples. Three types of fatty acid-based hydrophobic deep eutectic solvents (DESs) with low viscosity, low-d., and m.p. close to room temperature were prepared and employed as extraction solvents. This air-assisted liquid-liquid microextraction was carried out in a glass centrifuge tube. Subsequently, the glass tube was introduced into ice-water bath and held for 3 min, during which the upper DES phase was solidified. The water phase was easily extracted using a syringe equipped with a long needle, and later, the glass tube was removed from ice-water bath. The solidified DES phase was immediately melted at room temperature and used for HPLC anal. The response surface methodol. was employed to optimize some influencing parameters such as the volume of the extraction solvent, the pH value of sample solution, the number of extraction cycles, and the addition of salt. A quadratic model, namely a central composite design, was used to replace the conventional single factor anal. It was found that under optimal conditions, the limits of determination and quantification were 0.045-0.54μg L-1 and 0.15-2.0μg L-1, resp. The relative standard deviations for inter-day (n = 5) and intra-day (n = 5) precision were ≤ 4.2%, whereas the enrichment factors for the UV filters were obtained from 41 to 50. Furthermore, this novel method was successfully employed for the detection of benzophenone and salicylate UV filters from real water samples. The recoveries ranged from 87.5% to 105.8%, whereas the RSDs were lower than 3.6%. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Synthetic Route of 118-55-8

The Article related to air assisted microextraction deep eutectic uv filter water analysis, air-assisted liquid-liquid microextraction, deep eutectic solvent, response surface methodology, ultraviolet filters and other aspects.Synthetic Route of 118-55-8

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics