Category: 118-55-8

On February 28, 2018, Kamata, Ryo; Nakajima, Daisuke; Shiraishi, Fujio published an article.SDS of cas: 118-55-8 The title of the article was Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. And the article contained the following:

The constitutive androstane receptor (CAR) is a nuclear receptor and transcription factor regulating proteins involved in xenobiotic metabolism Agonist activation of the CAR can trigger metabolic activation and toxification as well as detoxification and clearance; accordingly, xenobiotic substances acting as CAR ligands may pose a threat to human and animal health. The authors used yeast cells transduced with the human CAR and the response pathway to measure the CAR-agonistic activities of 549 synthetic or natural compounds: 216 of the tested compounds exhibited CAR-agonistic effects. Eighty-four percent of CAR-activating compounds were aromatic compounds, and >65% of these active compounds were aromatic hydrocarbons, bisphenols, monoalkyl phenols, phthalates, styrene dimers, di-Ph ethers, organochlorines, and organophosphates. The ten most potent compounds were 4-tert-octylphenol (4tOP; reference substance), 4-nonylphenol, diethylstilbestrol, benzyl Bu phthalate, 2-(4-hydroxyphenyl)-2,4,4-trimethylchroman, o,p’-DDT, methoxychlor, di-Pr phthalate, hexestrol, and octachlorostyrene. The activities of these nine non-reference compounds exceeded 10% of the 4tOP activity. Anal. of para-monoalkyl phenols suggests that branching of the alkyl group and chlorination at the ortho position raises potency. This study provides critical information for identifying the potential of CAR-mediated toxic hazards and for understanding the relevant mechanism. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).SDS of cas: 118-55-8

The Article related to xenobiotic constitutive androstane receptor, alkyl phenol, bisphenol, constitutive androstane receptor, organochlorine, recombinant yeast, styrene dimer, Toxicology: Methods (Including Analysis) and other aspects.SDS of cas: 118-55-8

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Caruthers, J. M.; Medvedev, G. A. published an article in 2018, the title of the article was Quantitative model of super-Arrhenian behavior in glass forming materials.HPLC of Formula: 118-55-8 And the article contains the following content:

The key feature of glass forming liquids is the super-Arrhenian temperature dependence of the mobility, where the mobility can increase by ten orders of magnitude or more as the temperature is decreased if crystallization does not intervene. A fundamental description of the super-Arrhenian behavior has been developed; specifically, the logarithm of the relaxation time is a linear function of 1/Ux, where Ux is the independently determined excess molar internal energy and B is a material constant This one-parameter mobility model quant. describes data for 21 glass forming materials, which are all the materials where there are sufficient exptl. data for anal. The effect of pressure on the loga mobility is also described using the same Ux(T,p) function determined from the difference between the liquid and crystalline internal energies. It is also shown that B is well correlated with the heat of fusion. The prediction of the B/Ux model is compared to the Adam and Gibbs 1/TSx model, where the B/Ux model is significantly better in unifying the full complement of mobility data. The implications of the B/Ux model for the development of a fundamental description of glass are discussed. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).HPLC of Formula: 118-55-8

The Article related to glass forming material super arrhenian mobility math model, Placeholder for records without volume info and other aspects.HPLC of Formula: 118-55-8

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Novikov, V. N. published an article in 2022, the title of the article was Upper bound of fragility from spatial fluctuations of shear modulus and boson peak in glasses.Name: Phenyl Salicylate And the article contains the following content:

It is shown that the normalized rms fluctuation of the shear modulus on the medium-range order scale in glasses correlates with fragility: the higher fragility, the smaller the fluctuation amplitude. The latter is calculated within the heterogeneous elasticity theory using the data on the boson peak in glasses. On a smaller scale corresponding to cooperative structural relaxation, the normalized rms fluctuation of the infinite-frequency shear modulus was estimated using the data on the decoupling of viscosity and diffusion in supercooled liquids These fluctuations are much smaller in amplitude, and, in contrast, they increase with increasing fragility. Extrapolation predicts intersection of both rms fluctuations and disappearing of the boson peak at the upper limit to fragility ′180. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Name: Phenyl Salicylate

The Article related to boson peak glass shear modulus fragility spatial fluctuation, Placeholder for records without volume info and other aspects.Name: Phenyl Salicylate

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Kusumoto, Sotaro; Koga, Atsushi; Kobayashi, Fumiya; Ohtani, Ryo; Kim, Yang; Lindoy, Leonard F.; Hayami, Shinya; Nakamura, Masaaki published an article in 2019, the title of the article was Weak ferromagnetism derived from spin canting in an amido-bridged homochiral Mn(III) 1-D coordination polymer.Application of 118-55-8 And the article contains the following content:

A homochiral one-dimensional (1D) Mn(III) coordination polymer [MnL]n (1) was synthesized employing the N3O-donor tetradentate ligand (L = 2-hydroxy-N-[2-[[(2-aminophenyl)methylene]amino]-2-methylpropyl]-benzamide). The X-ray structure of 1 and its magnetic properties were investigated in detail. The crystal structure of 1 shows a homochiral helical arrangement in which spontaneous resolution has occurred, despite the ligand being achiral. Magnetic characterization revealed an antiferromagnetic interaction between manganese(III) ions (J = -2.48 cm-1, g = 1.96) that leads to an antiferromagnetic spin-ordering phase transition at TN ≈ 7 K. Noteworthily, 1 exhibits weak ferromagnetism with a relatively large coercive field of 3.0 kOe based on the spin canting, indicating the formation of a homochiral weak ferromagnet. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Application of 118-55-8

The Article related to polymer amido bridge manganese complex spin canting ferromagnetism, Placeholder for records without volume info and other aspects.Application of 118-55-8

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Yang, Shilun; Li, Simeng; Chang, Junlei published an article in 2022, the title of the article was Discovery of Cobimetinib as a novel A-FABP inhibitor using machine learning and molecular docking-based virtual screening.Recommanded Product: Phenyl Salicylate And the article contains the following content:

Adipocyte fatty acid-binding protein (A-FABP, also called FABP4, aP2) is an adipokine identified as a critical regulator of metabolic function due to its dual functions of fatty acid transport and pro-inflammation. Because of the high therapeutic potential of A-FABP inhibition for the treatment of metabolic diseases and related vascular complications, numerous inhibitors have been developed against A-FABP. However, none of these inhibitors have been approved for use in patients due to severe side effects. Here, we used a virtual screening (VS) strategy to identify potential inhibitors of A-FABP in the latest FDA-approved drug library (∼2600 compounds), aiming to explore the existing drugs with proven safety profiles. We firstly combined ligand-based machine learning and structure-based mol. docking to develop a screening pipeline for identifying A-FABP inhibitors. The screening of FDA-approved drugs identified four compounds (Cobimetinib, Larotrectinib, Pantoprazole, and Vildagliptin) with the highest scores, whose inhibitory effects on A-FABP were further assessed in cellular assays. Among the selected compounds, Cobimetinib significantly inhibited the activation of the JNK/c-Jun signaling pathway by A-FABP in mouse macrophages without causing obvious cytotoxicity. In summary, we present an integrated VS pipeline for A-FABP inhibitor screening, and identified Cobimetinib as a novel A-FABP inhibitor that may be repurposed for the treatment of metabolic diseases and associated vascular complications. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Recommanded Product: Phenyl Salicylate

The Article related to cobimetinib antimetabolic agent fabp4 drug target metabolic disease, Placeholder for records without volume info and other aspects.Recommanded Product: Phenyl Salicylate

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On February 28, 2022, Orikasa, Isamu; Osada, Takuma; Inatomi, Yuko; Ueno, Ichiro; Suzuki, Shinsuke published an article.COA of Formula: C13H10O3 The title of the article was Natural convection induced by unintended horizontal temperature distribution in a narrow-closed container heated from above. And the article contained the following:

This study aims at expressing the velocity fields of the liquids held in a narrow-closed container heated from above as a function of the dimensions of the container to estimate the diffusion-dominant condition. The motions of tracer particles in liquid salol held in a quasi-two-dimensional glass cell were tracked in cavities of various inner width W through the series of experiments The mean velocity of the tracer particles, Vmean, decreased almost linearly with the decrease in the values of W. Thermal flow fields were successfully reproduced by the series of numerical simulations. We found that the unintended horizontal temperature difference is realized, which induces the natural convection in the closed narrow cavity heated from above. We derived the correlation between the Reynolds and Grashof numbers, which are described as a function of the mean velocity and the unintended horizontal temperature difference, resp. The threshold of the convection onset in the present geometry was then proposed. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).COA of Formula: C13H10O3

The Article related to container heat natural convection horizontal temperature distribution, Placeholder for records without volume info and other aspects.COA of Formula: C13H10O3

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On March 31, 2020, Liu, Tao; Yuan, Xiaoxue; Zhang, Gang; Hu, Jing; An, Jing; Chen, Tong; Wang, Gongying published an article.Name: Phenyl Salicylate The title of the article was Stir bar sorptive extraction and automatic two-stage thermal desorption-gas chromatography-mass spectrometry for trace analysis of the byproducts from diphenyl carbonate synthesis. And the article contained the following:

In this study, a fast and sensitive method based on stir bar sorptive extraction (SBSE) and two-step thermal desorption coupled with online gas chromatog.-mass spectrometry was established to simultaneously analyze six trace byproducts [phenyl salicylate (PS), xanthone (XA), Me o-hydroxybenzoate (MS), 2-Me di-Ph carbonate (PTC), Me o-methoxybenzoate (MSME) and Ph o-methoxybenzoate (PSME)] generated in the process of di-Ph carbonate (DPC) synthesis. Under the optimal conditions, the six byproducts generated in the synthesis of DPC via transesterification were quant. analyzed by external standard method. The results showed that, within the range of 1.0-100 ng/L for all of the six transesterification byproducts, this method revealed good linearity with correlation coefficients (r) ≥0.997. The limits of detection (LODs) were between 0.054 ng/L and 0.253 ng/L, the relative standard deviations (RSD) were from 5.2% to 11.5%, and the recoveries were 81.6%-102.6% (n = 3). The method is simple, rapid and has a wide linear range, high accuracy, and sensitivity, as well as good stability. It is suitable for simultaneous, rapid and selective anal. of six trace byproducts in the process of DPC synthesis. It can also provide vigorous data support and industrialization guidance for the selection of transesterification conditions and research on the formation mechanisms, distribution regularity, and even control of transesterification byproducts. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Name: Phenyl Salicylate

The Article related to diphenyl carbonate synthesis trace analysis sorptive extraction thermal desorption, Placeholder for records without volume info and other aspects.Name: Phenyl Salicylate

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On September 28, 2020, Koerber, Thomas; Staeglich, Robert; Gainaru, Catalin; Boehmer, Roland; Roessler, Ernst A. published an article.Application In Synthesis of Phenyl Salicylate The title of the article was Systematic differences in the relaxation stretching of polar molecular liquids probed by dielectric vs magnetic resonance and photon correlation spectroscopy. And the article contained the following:

Relaxation spectra of mol. glass formers devoid of secondary relaxation maxima, as measured by dielec. spectroscopy (DS), NMR relaxometry, photon correlation spectroscopy (PCS), and Fabry-Perot interferometry, are quant. compared in terms of the Kohlrausch stretching parameter βK. For a reliable estimate of βK, the excess wing contribution has to be included in the spectral anal. The relaxation stretching probed by PCS and NMR varies only weakly among the liquids (βK = 0.58 ± 0.06). It is similar to that found in DS, provided that the liquid is sufficiently nonpolar (relaxation strength Δε≲6). For larger strengths, larger βDSK (narrowed relaxation spectra) are found when compared to those reported from NMR and PCS. Frequency-temperature superposition (FTS) holds for PCS and NMR. This is demonstrated by data scaling and, for the few glass formers for which results are available, by the equivalence of the susceptibilities χ′′PCS(ωτ) ∼ χ′′NMR(τ) ∼ χ′′NMR(ω), i.e., measuring at a constant frequency is equivalent to measuring at a constant temperature or constant correlation time. In this context, a plot of the spin-lattice relaxation rate R1(T) as a function of the spin-spin relaxation rate R2(T) is suggested to reveal the stretching parameter without the need to perform frequency-dependent investigations. Dielec., we identify a trend of increasing deviations from FTS with increasing Δε. Depending on the technique and glass former, the relative relaxation strength of the excess wing varies, whereas its exponent appears to be method independent for a given substance. For polar liquids, we discuss possible reasons for the discrepancy between the results from PCS and NMR as compared to those from DS. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Application In Synthesis of Phenyl Salicylate

The Article related to relaxation stretching polar liquid nmr dielec photon correlation spectroscopy, Placeholder for records without volume info and other aspects.Application In Synthesis of Phenyl Salicylate

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Rabie, Samira T.; Abdel Monem, Reham A. published an article in 2018, the title of the article was Effect of some biologically active pyridopyrimidine derivatives on photostability and bioactivity of rigid poly(vinyl chloride).SDS of cas: 118-55-8 And the article contains the following content:

Some pyridopyrimidine derivatives with high biol. activity have been investigated as photostabilizers for rigid Poly(vinyl chloride) (PVC). Their stabilizing efficiencies were evaluated by determining the percentage of weight loss, the amount of formed gel, as well as the intrinsic viscosities, of the photodegraded PVC. The extent of discoloration of the photodegraded polymer was also evaluated. The antimicrobial activities of PVC was evaluated in absence and in presence of the investigated materials. The applied materials reduced the loss in weight that resulted from HCl evolution during photodegradation Both viscosity and gel content measurements showed also a decrease in their values during the degradation process. The extent of discoloration was also improved. The results have proved a greater stabilizing efficiencies of the antimicrobial pyridopyrimidine derivatives than that of the industrial UV absorber, Ph salicylate. Photostabilized samples of PVC exhibited good antimicrobial activities against some types of bacteria and fungi. A radical mechanism was proposed to account for the stabilizing action of the investigated products. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).SDS of cas: 118-55-8

The Article related to polyvinyl chloride pyridopyrimidine derivative photostability bioactivity, Placeholder for records without volume info and other aspects.SDS of cas: 118-55-8

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Zhang, Jiulong; Li, Jiuyang; Li, Xun; Yuan, Shou; Sun, Yan; Zou, Yunlong; Pan, Yingtong; Zhang, Kaka published an article in 2022, the title of the article was Boosting organic afterglow efficiency via triplet-triplet annihilation and thermally-activated delayed fluorescence.Computed Properties of 118-55-8 And the article contains the following content:

Due to the spin-forbidden nature of organic phosphorescence, it is challenging to achieve high afterglow efficiency in room-temperature organic afterglow systems, especially for those with long afterglow emission wavelengths. Here we report the incorporation of triplet-triplet annihilation (TTA) and thermally-activated delayed fluorescence (TADF) mechanisms to significantly enhance the organic afterglow efficiency in dopant-matrix systems under ambient conditions. Difluoroboron β-diketonate (BF2bdk) compounds are selected as luminescent dopants and designed with naphthalene functional groups to show a relatively strong tendency of intersystem crossing. 4-Methoxybenzophenone matrixes are employed to facilitate intersystem crossing of BF2bdk excited states via dipole-dipole interactions and meanwhile suppress nonradiative decay and quenching of BF2bdk triplet excited states. Besides phosphorescence decay, the dopant-matrix systems exhibit addnl. pathways to harvest triplet energies via TTA and TADF, leading to the significant improvement of the organic afterglow efficiency. The afterglow materials can be melt-cast into desired shapes, can function as multicolor-encoded anti-counterfeiting objects, and can be processed into aqueous dispersions, which display background-free bioimaging properties. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Computed Properties of 118-55-8

The Article related to thermally activated delayed fluorescence cascade reaction organic afterglow, Placeholder for records without volume info and other aspects.Computed Properties of 118-55-8

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