Reference of 115913-32-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115913-32-1, name is Dimethyl bicyclo[1.1.1]pentane-1,3-dicarboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
50 Ml three-mouth bottle added 1.48 g bicyclo [1.1.1] pentane – 1, 3 – dicarboxylic acid dimethyl ester, its use 20 ml methanol dissolved, slowly dropping NaOH at room temperature (324 mg) in methanol (5 ml) solution, after adding up to 80 C reaction 2 h. After the reaction is finished concentrated to dry, add 40 ml water, dichloromethane is used for extraction (50 ml * 3), the water layer to adjust the PH dilute hydrochloric acid, adding dichloromethane extraction (40 ml * 4), the combined organic layer, drying the concentrated white solid 925 mg, yield 68%.
The synthetic route of Dimethyl bicyclo[1.1.1]pentane-1,3-dicarboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sichuan Bai Li Pharmaceutical Co., Ltd.; Zhu Yi; Li Jie; Liu Weijia; Wan Weili; Zhuo Shi; (26 pag.)CN109180681; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics