Category: 115118-68-8

Synthetic Route of 115118-68-8,Some common heterocyclic compound, 115118-68-8, name is Diisopropyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate, molecular formula is C14H24O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediates Ia and Ib are prepared by the methods described in literatures. Dissolve 15 g of intermediate Ibin 200 mL of ethanol, add 30 mL of NaOH (12 g, 0.3mol) aqueous solution, reflux the reaction solution for 3 hours, filterit in vacuum to obtain white solid and wash it with ethanol for 3 times to obtain intermediate Ic.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Diisopropyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate, its application will become more common.

Reference:
Patent; Southeast University; GOU, Shaohua; EP2913335; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 115118-68-8, name is Diisopropyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Diisopropyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate

Compound 29.3 (150 g, 0.52 mol) was added to a solutionof 10 M HCI (400 ml), andthe reaction mixture was heated to reflux for 60 hr.The reactionmixture was cooledto rt, extracted with Et20 (10 x 1 L) and the combinedorganic layers were dried, filteredand concentrated under reduced pressureto give compound 29.4 (65 g) as a yellow oil, which was5 carriedthrough to the next step withoutfurther purification..

According to the analysis of related databases, 115118-68-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACHAOGEN, INC.; LINSELL, Martin Sheringham; AGGEN, James Bradley; DOZZO, Paola; HILDEBRANDT, Darin James; COHEN, Frederick; KASAR, Ramesh Annasaheb; KANE, Timothy Robert; GLIEDT, Micah James; MCENROE, Glenn A.; WO2014/165075; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some common heterocyclic compound, 115118-68-8, name is Diisopropyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate, molecular formula is C14H24O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 115118-68-8

Reference Example 3 3-Oxocyclobutane carboxylic acid To diisopropyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate (760 g) obtained from Reference example 2, 20% of hydrochloric acid solution (3.2 L) was added and the mixture was refluxed for four days. After that, the reaction solution was extracted with ethyl acetate, and then the organic layer was dried over magnesium sulfate. Solids were removed, the filtrate was dried under reduced pressure to obtain the title product (700 g). 1H-NMR (CDCl3): 11.2 (1H, s), 3.41 (5H, m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 115118-68-8, its application will become more common.

Reference:
Patent; Asahi Kasei Pharma Corporation; US2009/298894; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115118-68-8 name is Diisopropyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 115118-68-8

3-Oxo-cyclobutanecarboxylic acid; [1244] 3,3-Dimethoxy-cyclobutane-1,1-dicarboxylic acid diisopropyl ester (0.1 mmol, 30 g) was refluxed in 20% HCI aqueous solution for 60 h. Part of the HCI aqueous solution was evaporated under high vacuum and light brown color oil remained. The oil was dissolved by EtOAc and washed by brine. The organic layer was dried by NaS04, filtered, and evaporated under vacuum. The title compound was obtained as an off-white solid after recrystallization from chloroform.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diisopropyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate, and friends who are interested can also refer to it.

Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2005/97800; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics