Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1150164-80-9, name is Ethyl 2,2-difluoro-2-(2-methoxyphenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Ethyl 2,2-difluoro-2-(2-methoxyphenyl)acetate
General procedure: To a solution of an appropriate ethyl alpha,alpha-difluoroaryl acetate (1.0 eq.) in MeOH (0.33 M) was added 1 M aq. K2CO3 (3.0 eq.). The reaction mixture was stirred at room temperature for 12 h before diluting with Et2O. The reaction mixture was extracted with aq. NaHCO3 (sat., 3x). The combined aqueous layers were acidified to pH 1 and extracted with Et2O (3x), then the combined organic phases were washed with brine, dried over MgSO4 and concentrated in vacuo. Products were purified by washing with n-pentane.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1150164-80-9.
Reference:
Article; Verhoog, Stefan; Pfeifer, Lukas; Khotavivattana, Tanatorn; Calderwood, Samuel; Collier, Thomas Lee; Wheelhouse, Katherine; Tredwell, Matthew; Gouverneur, Veronique; Synlett; vol. 27; 1; (2016); p. 25 – 28;,
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